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21.发明授权公开(公告)号：US08362022B2
公开(公告)日：2013-01-29
申请号：US12811773
申请日：2009-01-14
申请人： Todd M. Heidelbaugh , Ken Chow , Santosh C. Sinha , Phong X. Nguyen , Wenkui K. Fang , Ling Li , Janet A. Takeuchi , Smita S. Bhat
发明人： Todd M. Heidelbaugh , Ken Chow , Santosh C. Sinha , Phong X. Nguyen , Wenkui K. Fang , Ling Li , Janet A. Takeuchi , Smita S. Bhat
IPC分类号： A61K31/497 , A61K31/4439
CPC分类号： C07D401/12 , C07D233/48 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The invention provides well-defined heterocyclic compounds that are useful as subtype selective alpha 2 adrenergic agonists. As such, the compounds described herein, having the structure: are useful in treating a wide variety of disorders associated with selective subtype modulation of alpha 2 adrenergic receptors.
摘要翻译： 本发明提供了明确定义的杂环化合物，其可用作亚型选择性α2肾上腺素能激动剂。 因此，本文所述的具有以下结构的化合物可用于治疗与α2肾上腺素能受体的选择性亚型调节相关的多种疾病。
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公开(公告)号：US08258167B2
公开(公告)日：2012-09-04
申请号：US12436839
申请日：2009-05-07
IPC分类号： A01N43/50 , A61N31/415
CPC分类号： A61K31/4174
摘要： Disclosed herein is a method of treating stress urinary incontinence comprising administering a compound to a mammal in need thereof, wherein said compound has the formula Compositions and medicaments related thereto are also disclosed.
摘要翻译： 本文公开了一种治疗压力性尿失禁的方法，包括向有需要的哺乳动物施用化合物，其中所述化合物具有式其组合物和与之有关的药物也被公开。
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23.发明申请UNSUBSTITUTED AND SUBSTITUTED 4-BENZYL-1,3-DIHYDRO-IMIDAZOLE-2-THIONES ACTING AS SPECIFIC OR SELECTIVE ALPHA2 ADRENERGIC AGONISTS AND METHODS FOR USING THE SAME 审中-公开作为特异性或选择性ALPHA2 ADRENERGIC AGONISTS的不考虑和取代的4-苄氧基-1,3-二氢-1H-咪唑-2-酮及其使用方法公开(公告)号：US20120196911A1
公开(公告)日：2012-08-02
申请号：US13447607
申请日：2012-04-16
申请人： Todd M. Heidelbaugh , Ken Chow , Phong X. Nguyen , Daniel W. Gil , John E. Donello , Michael E. Garst , Larry A. Wheeler , John R. Cappiello
发明人： Todd M. Heidelbaugh , Ken Chow , Phong X. Nguyen , Daniel W. Gil , John E. Donello , Michael E. Garst , Larry A. Wheeler , John R. Cappiello
IPC分类号： A61K31/4174 , A61P27/02 , A61P19/02 , A61P37/00
CPC分类号： A61K31/4166 , C07D233/84
摘要： Compounds of Formula 1 where the variables have the meaning defined in the specification are used to activate alpha2 adrenergic receptors. The compounds of Formula 1 are incorporated in pharmaceutical compositions and are used as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2 adrenergic receptors.
摘要翻译： 变量具有本说明书中定义的含义的式1化合物用于激活α2肾上腺素能受体。 式1的化合物掺入药物组合物中，并且用作哺乳动物（包括人）中的药物，用于治疗对α2肾上腺素能受体激动剂治疗有反应的疾病和/或缓解的病症。
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24.发明授权Unsubstituted and substituted 4-benzyl-1,3-dihydro-imidazole-2-thiones acting as specific or selective alpha2 adrenergic agonists and methods for using the same 失效作为特异性或选择性α2肾上腺素能激动剂的未取代和取代的4-苄基-1,3-二氢 - 咪唑-2-硫酮及其使用方法公开(公告)号：US08178571B2
公开(公告)日：2012-05-15
申请号：US12849469
申请日：2010-08-03
申请人： Todd M. Heidelbaugh , Ken Chow , Phong X. Nguyen , Daniel W. Gil , John E. Donello , Michael Garst , Larry A. Wheeler , John R. Cappiello
发明人： Todd M. Heidelbaugh , Ken Chow , Phong X. Nguyen , Daniel W. Gil , John E. Donello , Michael Garst , Larry A. Wheeler , John R. Cappiello
IPC分类号： A61K31/4164 , C07D233/84
CPC分类号： A61K31/4166 , C07D233/84
摘要： Compounds of Formula 1 where the variables have the meaning defined in the specification are used to activate alpha2 adrenergic receptors. The compounds of Formula 1 are incorporated in pharmaceutical compositions and are used as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2 adrenergic receptors.
摘要翻译： 变量具有本说明书中定义的含义的式1化合物用于激活α2肾上腺素能受体。 式1的化合物掺入药物组合物中，并且用作哺乳动物（包括人）中的药物，用于治疗对α2肾上腺素能受体的激动剂治疗有反应的疾病和/或缓解的病症。
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公开(公告)号：US08119807B2
公开(公告)日：2012-02-21
申请号：US12522878
申请日：2008-01-04
IPC分类号： C07D215/38
CPC分类号： C07D401/06
摘要： Disclosed herein is a compound of the formula (I): (I). Therapeutic methods, compositions and medicaments related thereto are also disclosed.
摘要翻译： 本文公开了式（I）的化合物：（I）。 还公开了与此相关的治疗方法，组合物和药物。
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26.发明申请PYRIDINE COMPOUNDS AS SUBTYPE SELECTIVE MODULATORS OF ALPHA2B AND /OR ALPHA 2C ADRENERGIC RECEPTORS 审中-公开作为ALPHA2B和/或ALPHA 2C ADRENERGIC受体的亚型选择性调节剂的吡啶化合物公开(公告)号：US20110306635A1
公开(公告)日：2011-12-15
申请号：US13147664
申请日：2010-02-04
申请人： Phong X. Nguyen , Todd M. Heidelbaugh , Santosh C. Sinha , Ken Chow , Michael E. Garst , Daniel W. Gil
发明人： Phong X. Nguyen , Todd M. Heidelbaugh , Santosh C. Sinha , Ken Chow , Michael E. Garst , Daniel W. Gil
IPC分类号： C07D401/06 , A61K31/4709 , A61P29/00 , A61K31/4439
CPC分类号： C07D401/06
摘要： The invention relates specifically to the use of certain 4-[1-(1H-Imidazol-4-yl)-ethyl]-2,3-substituted pyridine compounds and pharmaceutical compositions thereof to treat disorders associated with selective subtype alpha 2 adrenergic receptor modulation.
摘要翻译： 本发明具体涉及使用某些4- [1-（1H-咪唑-4-基） - 乙基] -2,3-取代的吡啶化合物及其药物组合物来治疗与选择性亚型α2肾上腺素能受体调节相关的病症 。
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公开(公告)号：US08013169B2
公开(公告)日：2011-09-06
申请号：US12522882
申请日：2008-01-04
IPC分类号： C07D233/64
CPC分类号： C07D233/64
摘要： Disclosed herein is a compound of the formula (a): Therapeutic methods, compositions and medicaments related thereto are also disclosed.
摘要翻译： 本文公开了式（a）的化合物：还公开了与其有关的治疗方法，组合物和药物。
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公开(公告)号：US20110028523A1
公开(公告)日：2011-02-03
申请号：US12828429
申请日：2010-07-01
申请人： Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Wenkui K. Fang , Santosh C. Sinha , Michael E. Garst , Daniel W. Gil
发明人： Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Wenkui K. Fang , Santosh C. Sinha , Michael E. Garst , Daniel W. Gil
IPC分类号： A61K31/426 , C07D263/28 , A61K31/421 , C07D277/18 , A61P27/06 , A61P25/02 , A61P25/30 , A61P9/00 , A61P3/10 , A61P3/04 , A61P25/28 , A61P25/16 , A61P25/22 , A61P25/24 , A61P27/02 , A61P19/02 , A61P1/00 , A61P17/06
CPC分类号： C07D277/18 , C07D263/28
摘要： Described herein are compounds useful as agonists of alpha 2B/2C receptors. Pharmaceutical compositions including the presently described compounds and methods of treatment of diseases and conditions with the presently described compounds also are disclosed.
摘要翻译： 本文描述的是可用作α2B / 2C受体激动剂的化合物。 还公开了包括目前描述的化合物的药物组合物和用目前描述的化合物治疗疾病和病症的方法。
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29.发明申请N-(1-PHENYL-2-ARYLETHYL)-4,5-DIHYDRO-2H-PYRROL-5-AMINE COMPOUNDS AS SUBTYPE SELECTIVE MODULATORS OF ALPHA2B OR ALPHA2B AND ALPHA2C ADRENOCEPTORS 失效作为ALPHA2B或ALPHA2B和ALPHA2C ADRENOCEPTORS的亚型选择性调节剂的N-（1-苯基-2-芳基）-4,5-二氢-2H-吡喃-5-胺化合物公开(公告)号：US20100145061A1
公开(公告)日：2010-06-10
申请号：US12632494
申请日：2009-12-07
申请人： Ken Chow , Janet A. Takeuchi , Ling Li , Todd M. Heidelbaugh , Phong X. Nguyen , Evelyn G. Corpuz , Wenkui K. Fang , Santosh C. Sinha , Michael E. Garst
发明人： Ken Chow , Janet A. Takeuchi , Ling Li , Todd M. Heidelbaugh , Phong X. Nguyen , Evelyn G. Corpuz , Wenkui K. Fang , Santosh C. Sinha , Michael E. Garst
IPC分类号： C07D401/12 , C07D207/50
CPC分类号： C07D207/22 , C07D401/12
摘要： The present invention provides compounds which are N-(1-phenyl-2-arylethyl)-4,5-dihydro-2H-pyrrol-5-amine compounds and are subtype selective modulators of alpha 2B or alpha 2B and alpha 2C adrenoreceptors and are selected from the group of compounds represented by the formula
摘要翻译： 本发明提供了N-（1-苯基-2-芳基乙基）-4,5-二氢-2H-吡咯-5-胺化合物的化合物，并且是α2B或α2B和α2C肾上腺素受体的亚型选择性调节剂，并且是 选自由式表示的化合物组
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公开(公告)号：US20100004305A1
公开(公告)日：2010-01-07
申请号：US12522882
申请日：2008-01-04
IPC分类号： A61K31/4164 , C07D233/56 , A61P29/00 , A61P27/06
CPC分类号： C07D233/64
摘要： Disclosed herein is a compound of the formula (a): Therapeutic methods, compositions and medicaments related thereto are also disclosed.
摘要翻译： 本文公开了式（a）的化合物：还公开了与其有关的治疗方法，组合物和药物。
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