公开(公告)号：US09498283B2

公开(公告)日：2016-11-22

申请号：US14601529

申请日：2015-01-21

申请人： The Foundry, LLC

发明人： Mark E. Deem ,  Hanson Gifford

IPC分类号： C12M1/00 ,  A61B18/14 ,  A61K38/16 ,  A61K38/48 ,  A61K41/00 ,  A61N1/08 ,  A61N1/32 ,  A61N1/30 ,  A61N7/00 ,  A61K9/00 ,  A61B18/18 ,  A61N5/10 ,  A61B18/00

CPC分类号： A61M37/00 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/00434 ,  A61B2018/1861 ,  A61K9/0021 ,  A61K9/0078 ,  A61K38/164 ,  A61K38/168 ,  A61K38/4893 ,  A61K41/00 ,  A61K41/0028 ,  A61K41/0047 ,  A61M37/0092 ,  A61M2210/1035 ,  A61N1/08 ,  A61N1/303 ,  A61N1/327 ,  A61N5/10 ,  A61N7/00 ,  A61N2007/003 ,  C12Y304/24069 ,  Y02A50/471 ,  A61K2300/00

摘要： Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.

公开(公告)号：US09327104B2

公开(公告)日：2016-05-03

申请号：US14151767

申请日：2014-01-09

申请人： The Foundry, LLC

发明人： John Morriss ,  Cary Reich ,  Hanson Gifford

IPC分类号： A61M31/00 ,  A61K9/00 ,  A61K9/12

CPC分类号： A61K38/4893 ,  A61K9/0043 ,  A61K9/122 ,  A61M31/00 ,  C12Y304/24069

摘要： A system for delivering a therapeutic agent to a nasopharyngeal mucosa target comprises a foam generating mechanism, a gas, a therapeutic agent in liquid form that inhibits mucus production, and a delivery device. Actuation of the foam generating mechanism entraps gaseous bubbles from the gas in the liquid thereby forming a foam. The therapeutic agent is dispersed in the foam which has an expanded configuration adapted to fill a nasopharyngeal space and deliver the therapeutic agent to the mucosa targets. The delivery device is for delivering the foam to the nasopharyngeal space. The foam may also have a collapsed configuration for removal from the nasopharyngeal space or for concentration of the therapeutic agent onto the mucosa.

摘要翻译： 用于将治疗剂递送到鼻咽粘膜靶的系统包括泡沫产生机构，气体，液体形式的抑制粘液生成的治疗剂和递送装置。 泡沫发生机构的致动从液体中的气体中捕获气泡，从而形成泡沫。 将治疗剂分散在具有适于填充鼻咽空间并将治疗剂递送至粘膜靶的膨胀构型的泡沫中。 输送装置用于将泡沫输送到鼻咽空间。 泡沫体还可以具有用于从鼻咽部空间除去或将治疗剂浓缩到粘膜上的收缩构型。