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公开(公告)号：US20180303841A1
公开(公告)日：2018-10-25
申请号：US15769295
申请日：2016-10-19
发明人： Takahiro SUGIMOTO , Shinkichi SUZUKI , Hiroki SAKAMOTO , Masami YAMADA , Minoru NAKAMURA , Makoto KAMATA , Kenichiro SHIMOKAWA , Masaki OGINO , Eiji KIMURA , Masataka MURAKAMI , Takuto KOJIMA , Jinichi YONEMORI
CPC分类号： A61K31/53 , A61K31/517 , A61P25/04 , A61P25/16 , A61P25/18 , A61P25/28 , C07D239/88 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/10 , C07D405/14
摘要： The present invention provides a compound which has a cholinergic muscarinic M1 receptor positive allosteric modulator activity and may be useful as a medicament such as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, Lewy body dementia and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof. In the formula (I), each symbol is as described in the attached specification.
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公开(公告)号：US20180155333A1
公开(公告)日：2018-06-07
申请号：US15568644
申请日：2016-04-22
发明人： Taku KAMEI , Yasuyoshi ARIKAWA , Tomohiro OHASHI , Toshihiro IMAEDA , Ikuo FUJIMORI , Takashi MIKI , Jinichi YONEMORI , Yuya OGURO , Takahiro SUGIMOTO , Masaki SETO , Goushi NISHIDA , Makoto KAMATA , Hiroshi IMOTO
IPC分类号： C07D413/14 , C07D413/04 , C07D417/14 , C07D409/14 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30
CPC分类号： C07D413/14 , A61K31/553 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , C07D409/14 , C07D413/04 , C07D417/14
摘要： The present invention provide a compound having an orexin receptor antagonistic activity, which is expected to be useful as medicaments such as agents for the prophylaxis or treatment of sleep disorder, depression, anxiety disorder, panic disorder, schizophrenia, drug dependence, Alzheimer's disease and the like.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
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公开(公告)号：US20170216255A1
公开(公告)日：2017-08-03
申请号：US15488002
申请日：2017-04-14
发明人： Masami YAMADA , Shinkichi SUZUKI , Takahiro SUGIMOTO , Minoru NAKAMURA , Hiroki SAKAMOTO , Makoto KAMATA
IPC分类号： A61K31/4035 , A61K31/55 , A61K31/4439 , A61K31/325 , A61K31/4155 , A61K31/445 , A61K31/13
CPC分类号： C07D405/14 , A61K31/045 , A61K31/13 , A61K31/325 , A61K31/4035 , A61K31/4155 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/55 , C07D209/46 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/04 , C07D471/04
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like.The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the specification, or a salt thereof.
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公开(公告)号：US20230040770A1
公开(公告)日：2023-02-09
申请号：US17427490
申请日：2020-01-30
发明人： Yasushi HATTORI , Yuhei MIYANOHANA , Tatsuki KAJITA , Tatsuki KOIKE , Yasutaka HOASHI , Norihito TOKUNAGA , Alexander Martin PAWLICZEK , Tsuneo ODA , Tohru MIYAZAKI , Yoshiteru ITO , Kohei TAKEUCHI , Keisuke IMAMURA , Takahiro SUGIMOTO
IPC分类号： C07D403/06 , C07D207/14
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.
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公开(公告)号：US20210276949A1
公开(公告)日：2021-09-09
申请号：US17239191
申请日：2021-04-23
发明人： Yasushi HATTORI , Yuhei MIYANOHANA , Yuichi KAJITA , Tatsuki KOIKE , Yasutaka HOASHI , Norihito TOKUNAGA , Alexander Martin PAWLICZEK , Tsuneo ODA , Tohru MIYAZAKI , Yoshiteru ITO , Kohei TAKEUCHI , Keisuke IMAMURA , Takahiro SUGIMOTO
IPC分类号： C07D207/14 , C07D407/08 , C07D417/06
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US20200207715A1
公开(公告)日：2020-07-02
申请号：US16811426
申请日：2020-03-06
发明人： Yuichi Kajita , Yuhei MIYANOHANA , Tatsuki KOIKE , Kohei TAKEUCHI , Yoshiteru ITO , Norihito TOKUNAGA , Takahiro SUGIMOTO , Tohru MIYAZAKI , Tsuneo ODA , Yasutaka HOASHI , Yasushi HATTORI , Keisuke IMAMURA
IPC分类号： C07D211/56 , C07D417/14 , C07D417/06 , C07D413/06 , C07D405/12 , C07D405/10 , C07D403/06 , C07D401/14 , C07D401/10 , C07D401/06 , C07D207/14 , C07D205/04 , A61P25/00 , C07D405/06 , C07D211/36
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.
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公开(公告)号：US20200017444A1
公开(公告)日：2020-01-16
申请号：US16577449
申请日：2019-09-20
发明人： Yuichi KAJITA , Satoshi MIKAMI , Yuhei MIYANOHANA , Tatsuki KOIKE , Masaki DAINI , Norio OYABU , Masaki OGINO , Kohei TAKEUCHI , Yoshiteru ITO , Norihito TOKUNAGA , Takahiro SUGIMOTO , Tohru MIYAZAKI , Tsuneo ODA , Yasutaka HOASHI , Yasushi HATTORI , Keisuke IMAMURA
IPC分类号： C07D211/56 , A61P25/00 , C07D205/04 , C07D207/14 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/10 , C07D405/12 , C07D413/06 , C07D417/06 , C07D417/14 , C07D211/36 , C07D405/06
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.
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28.发明申请公开(公告)号：US20190248776A1
公开(公告)日：2019-08-15
申请号：US16394762
申请日：2019-04-25
发明人： Takahiro SUGIMOTO , Shinkichi SUZUKI , Hiroki SAKAMOTO , Masami YAMADA , Minoru NAKAMURA , Makoto KAMATA , Kenichiro SHIMOKAWA , Masaki OGINO , Eiji KIMURA , Masataka MURAKAMI , Jinichi YONEMORI , Takuto KOJIMA
IPC分类号： C07D413/14 , C07D491/107 , C07D471/04 , C07D417/06 , C07D413/10 , C07D413/06 , C07D265/22 , C07F7/02 , C07D413/04 , C07F7/08 , A61P25/28 , C07D417/10
CPC分类号： C07D413/14 , A61P25/28 , C07B2200/07 , C07D265/22 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/10 , C07D471/04 , C07D491/107 , C07F7/02 , C07F7/0814
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, which may be useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof: wherein each symbol is as defined in the attached DESCRIPTION.
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公开(公告)号：US20180362516A1
公开(公告)日：2018-12-20
申请号：US16113635
申请日：2018-08-27
发明人： Takahiro SUGIMOTO , Shinkichi SUZUKI , Hiroki SAKAMOTO , Masami YAMADA , Minoru NAKAMURA , Makoto KAMATA , Kenichiro SHIMOKAWA , Takuto KOJIMA
IPC分类号： C07D413/14 , C07D413/06 , C07D471/04 , C07D491/107 , C07D413/04 , C07F7/02 , C07D417/06 , C07D265/22 , C07F7/08 , C07D417/10 , A61P25/28 , C07D413/10
CPC分类号： C07D413/14 , A61P25/28 , C07B2200/07 , C07D265/22 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/10 , C07D471/04 , C07D491/107 , C07F7/02 , C07F7/0814
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, which may be useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof: wherein each symbol is as defined in the attached DESCRIPTION.
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公开(公告)号：US20180050996A1
公开(公告)日：2018-02-22
申请号：US15799379
申请日：2017-10-31
发明人： Takahiro SUGIMOTO , Shinkichi SUZUKI , Hiroki SAKAMOTO , Masami YAMADA , Minoru NAKAMURA , Makoto KAMATA , Kenichiro SHIMOKAWA , Takuto KOJIMA
IPC分类号： C07D265/22 , C07F7/02 , C07D491/107 , C07D471/04 , C07D417/06 , C07D413/14 , C07D413/10 , C07D413/06 , C07D413/04
CPC分类号： C07D413/14 , A61P25/28 , C07B2200/07 , C07D265/22 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/10 , C07D471/04 , C07D491/107 , C07F7/02 , C07F7/0814
摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, which may be useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof: wherein each symbol is as defined in the attached DESCRIPTION.
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