公开(公告)号：US10709579B2

公开(公告)日：2020-07-14

申请号：US16142438

申请日：2018-09-26

Applicant: Robert Heald ,  Richard Lim

Inventor： Robert Heald ,  Richard Lim

IPC: A61F2/46 ,  A61L27/54 ,  A61B17/88 ,  A61F2/30 ,  A61F2/28 ,  A61B17/00

Abstract: The present disclosure provides a device and method for applying a bone graft material to the body. The device includes a cylinder into which bone graft material is loaded. Specifically, the bone graft material is loaded into the cylinder through a funnel at a proximal end of the cylinder and dispensed through a tip at a distal end of the cylinder. After the bone graft material is loaded, a sleeve within the cylinder can be removed in order to create a channel within the bone graft material. Water or other hydrating fluid may be inserted into the channel through a port adjacent the proximal end of the cylinder in order to hydrate the bone graft material.

公开(公告)号：US20190021878A1

公开(公告)日：2019-01-24

申请号：US16142438

申请日：2018-09-26

Applicant: Robert Heald ,  Richard Lim

Inventor： Robert Heald ,  Richard Lim

IPC: A61F2/46 ,  A61L27/54 ,  A61F2/30 ,  A61F2/28

CPC classification number: A61F2/4601 ,  A61B17/8819 ,  A61B17/8822 ,  A61B2017/0046 ,  A61F2/30723 ,  A61F2/4603 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61L27/54

Abstract: The present disclosure provides a device and method for applying a bone graft material to the body. The device includes a cylinder into which bone graft material is loaded. Specifically, the bone graft material is loaded into the cylinder through a funnel at a proximal end of the cylinder and dispensed through a tip at a distal end of the cylinder. After the bone graft material is loaded, a sleeve within the cylinder can be removed in order to create a channel within the bone graft material. Water or other hydrating fluid may be inserted into the channel through a port adjacent the proximal end of the cylinder in order to hydrate the bone graft material.

公开(公告)号：US20160016948A1

公开(公告)日：2016-01-21

申请号：US14745159

申请日：2015-06-19

Applicant: Marian C. Bryan ,  Bryan Chan ,  Emily Hanan ,  Timothy Heffron ,  Hans Purkey ,  Richard Leonard Elliott ,  Robert Heald ,  Jamie Knight ,  Michael Lainchbury ,  Eileen M. Seward

Inventor： Marian C. Bryan ,  Bryan Chan ,  Emily Hanan ,  Timothy Heffron ,  Hans Purkey ,  Richard Leonard Elliott ,  Robert Heald ,  Jamie Knight ,  Michael Lainchbury ,  Eileen M. Seward

IPC: C07D471/04 ,  A61K45/06 ,  C07D498/10 ,  A61K31/5355 ,  A61K31/541 ,  C07D498/08 ,  A61K31/538 ,  C07D491/107 ,  A61K31/506 ,  A61K31/5377

CPC classification number: C07D471/04 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/541 ,  A61K45/06 ,  C07D491/107 ,  C07D498/08 ,  C07D498/10 ,  C07D519/00

Abstract: This invention relates to novel compounds which are inhibitors of T790M containing EGFR mutants, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of cancer.

Abstract translation: 本发明涉及作为含有EGFR突变体的T790M抑制剂的新化合物，含有它们的药物组合物，其制备方法及其在治疗中用于预防或治疗癌症的新化合物。

公开(公告)号：US09090628B2

公开(公告)日：2015-07-28

申请号：US13424500

申请日：2012-03-20

Applicant: Timothy Heffron ,  Brian Safina ,  Steven Staben ,  Daniel P. Sutherlin ,  BinQing Wei ,  Richard Elliott ,  Robert Heald ,  Eileen M. Seward ,  Emanuela Gancia ,  Bohdan Waszkowycz

Inventor： Timothy Heffron ,  Brian Safina ,  Steven Staben ,  Daniel P. Sutherlin ,  BinQing Wei ,  Richard Elliott ,  Robert Heald ,  Eileen M. Seward ,  Emanuela Gancia ,  Bohdan Waszkowycz

IPC: A61K31/553 ,  C07D498/04 ,  C07D498/14 ,  C07D519/00

CPC classification number: C07D498/14 ,  C07D498/04 ,  C07D519/00

Abstract: Benzoxazepin Formula I compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract translation: 苯并西泮配方I化合物，包括立体异构体，几何异构体，互变异构体，代谢物及其药学上可接受的盐，可用于抑制PI3K的δ同种型，以及用于治疗脂质激酶如炎症，免疫学障碍和癌症介导的病症。 公开了使用式I化合物在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

公开(公告)号：US10271962B2

公开(公告)日：2019-04-30

申请号：US15810303

申请日：2017-11-13

Applicant: Robert Heald ,  Richard Lim

Inventor： Robert Heald ,  Richard Lim

IPC: A61F2/46 ,  A61L27/54 ,  A61F2/30 ,  A61F2/28

Abstract: The present disclosure provides a device and method for applying a bone graft material to the body. The device includes a cylinder into which bone graft material is loaded. Specifically, the bone graft material is loaded into the cylinder through a funnel at a proximal end of the cylinder and dispensed through a tip at a distal end of the cylinder. After the bone graft material is loaded, a sleeve within the cylinder can be removed in order to create a channel within the bone graft material. Water or other hydrating fluid may be inserted into the channel through a port adjacent the proximal end of the cylinder in order to hydrate the bone graft material.

公开(公告)号：US20180133027A1

公开(公告)日：2018-05-17

申请号：US15810303

申请日：2017-11-13

Applicant: Robert Heald ,  Richard Lim

Inventor： Robert Heald ,  Richard Lim

IPC: A61F2/46 ,  A61L27/54

CPC classification number: A61F2/4601 ,  A61B17/80 ,  A61B17/8802 ,  A61F2/30723 ,  A61F2/4603 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61L27/54

Abstract: The present disclosure provides a device and method for applying a bone graft material to the body. The device includes a cylinder into which bone graft material is loaded. Specifically, the bone graft material is loaded into the cylinder through a funnel at a proximal end of the cylinder and dispensed through a tip at a distal end of the cylinder. After the bone graft material is loaded, a sleeve within the cylinder can be removed in order to create a channel within the bone graft material. Water or other hydrating fluid may be inserted into the channel through a port adjacent the proximal end of the cylinder in order to hydrate the bone graft material.