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34 条记录 (耗时 0.031 秒)

    Method for forming cyclodextrin polymer and lipophilic compound emulsions, resulting emulsions, and compositions including said emulsions
    23.
    发明授权
    Method for forming cyclodextrin polymer and lipophilic compound emulsions, resulting emulsions, and compositions including said emulsions 失效
    形成环糊精聚合物和亲脂性复合乳液，所得乳液和包括所述乳液的组合物的方法

    公开(公告)号：US08741347B2

    公开(公告)日：2014-06-03

    申请号：US13265550

    申请日：2010-04-23

    申请人： Anca-Lucia Laza-Knoerr ,  Ruxandra Gref ,  Catherine Amiel ,  Patrick Couvreur

    发明人： Anca-Lucia Laza-Knoerr ,  Ruxandra Gref ,  Catherine Amiel ,  Patrick Couvreur

    IPC分类号： A61K9/14 ,  A61K47/40 ,  A61K9/107 ,  A61K8/73 ,  A61K8/06

    CPC分类号： A61K47/40 ,  A61K8/06 ,  A61K8/11 ,  A61K8/738 ,  A61K8/91 ,  A61K9/107 ,  A61Q17/04

    摘要： The present invention relates to a method for preparing a cyclodextrin polymer and/or a hydrophilic polymer emulsion having cyclodextrins as well as lipophilic compounds, the emulsions having a remarkable stability. In particular, the method includes: (i) adding a lipophilic compound into an aqueous solution of a cyclodextrin unit polymer or hydrophilic polymer having cyclodextrins; (ii) forming an emulsion from the mixture resulting from step (i). The invention also relates to the resulting emulsions, i.e. stabilized emulsions by a non-covalent and non-crystalline inclusion complex consisting of (i) a cyclodextrin unit polymer or a hydrophilic polymer having cyclodextrins and (ii) a lipophilic compound. The invention also relates to the use of said emulsions in the cosmetic, pharmaceutical and/or agri-food fields.

    摘要翻译： 本发明涉及一种制备环糊精聚合物和/或具有环糊精以及亲脂性化合物的亲水性聚合物乳液的方法，该乳液具有显着的稳定性。 特别地，该方法包括：（i）将亲脂性化合物加入到具有环糊精的环糊精单元聚合物或亲水性聚合物的水溶液中; （ii）从步骤（i）得到的混合物形成乳液。 本发明还涉及由（i）环糊精单元聚合物或具有环糊精的亲水性聚合物和（ii）亲脂性化合物组成的非共价和非结晶包合络合物得到的乳液，即稳定的乳液。 本发明还涉及在化妆品，药​​物和/或农业食品领域中所述乳剂的用途。

    Poly(methylidene malonate) microspheres, preparation method and pharmaceutical compositions containing them
    25.
    发明授权
    Poly(methylidene malonate) microspheres, preparation method and pharmaceutical compositions containing them 有权
    聚（亚甲基丙二酸酯）微球，制备方法和含有它们的药物组合物

    公开(公告)号：US06440461B1

    公开(公告)日：2002-08-27

    申请号：US09673255

    申请日：2000-12-19

    申请人： Nicole Bru-Magniez ,  Elias Fattal ,  Catherine Le Visage ,  Patrick Couvreur ,  Pascal Breton

    发明人： Nicole Bru-Magniez ,  Elias Fattal ,  Catherine Le Visage ,  Patrick Couvreur ,  Pascal Breton

    IPC分类号： A61K914

    CPC分类号： C08J3/14 ,  A61K9/1635 ,  A61K9/1641 ,  C08J2335/00

    摘要： The invention concerns novel microspheres particularly useful in pharmaceutics as particulate vectors for carrying biologically active substances, in particular hydrophilic substances, for oral administration. The invention is characterised in that said microspheres consist of a support material continuous lattice wherein is optionally dispersed a substance, said support material containing at least 70 wt. % of a homopolymer consisting of recurrent units corresponding to general formula (I): wherein: R1 represents an alkyl group containing 1 to 6 carbon atoms or a (CH2)m—COOR3 group wherein m is an integer ranging between 1 and 5 and R3 represents an alkyl group having 1 to 6 carbon atoms; R2 represents an alkyl group having 1 to 6 carbon atoms; and n is an integer ranging between 1 and 5. The invention is useful in pharmaceutics.

    摘要翻译： 本发明涉及在药物学中特别有用的新型微球，作为用于携带用于口服给药的生物活性物质，特别是亲水性物质的颗粒载体。 本发明的特征在于，所述微球由支撑材料连续晶格组成，其中任选地分散物质，所述载体材料含有至少70wt。 ％的由通式（I）表示的反复单元组成的均聚物：其中：R1表示含有1至6个碳原子的烷基或（CH2）m -COOR3基团，其中m为1至5的整数，R3为 表示碳原子数1〜6的烷基。 R2表示碳原子数1〜6的烷基， n为1〜5的整数。本发明可用于制药。

    STATIN NANOPARTICLES
    28.
    发明申请
    STATIN NANOPARTICLES 失效
    靛蓝纳米颗粒

    公开(公告)号：US20110269830A1

    公开(公告)日：2011-11-03

    申请号：US13126752

    申请日：2009-10-28

    申请人： Patrick Couvreur ,  Didier Desmaele ,  Fat'ma Zouhiri ,  Reddy Harivardhan Lakkireddy

    发明人： Patrick Couvreur ,  Didier Desmaele ,  Fat'ma Zouhiri ,  Reddy Harivardhan Lakkireddy

    IPC分类号： A61K31/215 ,  C07D309/30 ,  A61P3/06 ,  A61P9/00 ,  A61K31/366 ,  C07C69/732 ,  A61P3/04 ,  B82Y5/00 ,  B82Y40/00

    CPC分类号： C07C69/67 ,  A61K47/54 ,  A61K47/542 ,  C07C2602/28

    摘要： The present invention relates to a complex made up of at least one molecule of statin or a derivative thereof, covalently bonded to at least one hydrocarbon radical including at least 18 carbon atoms and containing at least one 2-methyl-buta-2-ene unit, to nanoparticles of such a complex, and to a method for preparing same, said complex and/or said nanoparticles optionally being in the form of a lyophilisate. The present invention also relates to a pharmaceutical composition including at least one complex and/or nanoparticles such as previously defined. The invention finally relates to said complex and/or to said nanoparticles for the treatment and/or prevention of hyperlipemia and hypercholesterolemia.

    摘要翻译： 本发明涉及由至少一种他汀类或其衍生物分子组成的复合物，其共价键合至至少一个包含至少18个碳原子的烃基，并含有至少一个2-甲基 - 丁-2-烯单元 对于这种复合物的纳米颗粒，以及制备其的方法，所述复合物和/或所述纳米颗粒任选地为冻干物形式。 本发明还涉及包含至少一种如前所定义的复合物和/或纳米颗粒的药物组合物。 本发明最终涉及用于治疗和/或预防高脂血症和高胆固醇血症的所述复合物和/或所述纳米颗粒。

    Aqueous dispersions of nanometric or micrometric particles for encapsulating chemical compounds
    30.
    发明授权
    Aqueous dispersions of nanometric or micrometric particles for encapsulating chemical compounds 失效
    用于封装化学化合物的纳米或微米颗粒的水分散体

    公开(公告)号：US07682635B2

    公开(公告)日：2010-03-23

    申请号：US10520657

    申请日：2003-07-01

    申请人： Ruxandra Gref ,  Catherine Amiel ,  Bernard Sebille ,  Patrick Couvreur

    发明人： Ruxandra Gref ,  Catherine Amiel ,  Bernard Sebille ,  Patrick Couvreur

    IPC分类号： A61K9/50

    CPC分类号： A61K9/5161 ,  A61K47/6951 ,  B82Y5/00

    摘要： A composition comprises an aqueous dispersion of particles (p) of mean hydrodynamic diameter between 50 and 5000 nm. The particles contain (A) polymers based on cyclodextrin units, comprising on average at least four cyclodextrin units within their structure; and (B) macromolecules of polysaccharides comprising groups G capable of forming inclusion complexes with the cyclodextrins present in the structure of the polymers (A), with an average number of groups G per polysaccharide macromolecule at least equal to three. The compounds (A) and (B) are water-soluble in the isolated state. A method is also provided which relates to the preparation of these compositions, as well as their use in order to achieve the encapsulation of compounds such as active substances.

    摘要翻译： 组合物包含平均流体动力学直径在50和5000nm之间的颗粒（p）的水分散体。 颗粒含有（A）基于环糊精单元的聚合物，其平均在其结构内包含至少四个环糊精单元; 和（B）包含能够与存在于聚合物（A）的结构中的环糊精形成包合物的基团G的多糖的大分子，每个多糖大分子的基团G的平均数目至少等于3。 化合物（A）和（B）在分离状态下是水溶性的。 还提供了涉及这些组合物的制备以及它们用于实现化合物如活性物质的包封的用途的方法。