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    Macrocyclic peptides active against the hepatitis C virus
    23.
    发明申请
    Macrocyclic peptides active against the hepatitis C virus 有权
    对丙型肝炎病毒有活性的大环肽

    公开(公告)号：US20060089300A1

    公开(公告)日：2006-04-27

    申请号：US11298443

    申请日：2005-12-10

    Applicant: Montse Llinas-Brunet ,  Murray Bailey

    Inventor： Montse Llinas-Brunet ,  Murray Bailey

    IPC: A61K38/12 ,  C07K5/12 ,  A61K31/496

    CPC classification number: C07K5/0802 ,  A61K38/00

    Abstract: Compounds of formula (I): wherein R1 is (C1-8)alkyl, (C3-7)cycloalkyl, {(C1-6)alkyl-(C3-7)cycloalkyl} or Het, which are all optionally substituted from 1 to 3 times with halo, cyano, nitro, O—(C1-6)alkyl, amido, amino or phenyl, or R1 is C6 or C10 aryl which is optionally substituted from 1 to 3 times with halo, cyano, nitro, (C1-6)alkyl, O—(C1-6)alkyl, amido, amino or phenyl; or a pharmaceutically acceptable salt thereof, useful as an inhibitor of the HCV NS3 protease.

    Abstract translation: 式（I）的化合物：其中R 1为（C 1-8 - ）烷基，（C 3-7）环烷基，{（ C 1-3烷基 - （C 3-7 N）环烷基}或Het，它们都可以任选被卤素，氰基，硝基，O - （C 1-6 - ）烷基，酰胺基，氨基或苯基，或R 1是C 6或C 10 - 任选被卤素，氰基，硝基，（C 1-6 - ）烷基，O-（C 1-6 - ）烷基取代1至3次的芳基， ，酰胺基，氨基或苯基; 或其药学上可接受的盐，可用作HCV NS3蛋白酶的抑制剂。

    Hepatitis C inhibitor tri-peptides
    25.
    发明授权
    Hepatitis C inhibitor tri-peptides 有权
    丙型肝炎抑制剂三肽

    公开(公告)号：US06642204B2

    公开(公告)日：2003-11-04

    申请号：US10353589

    申请日：2003-01-29

    Applicant: Montse Llinas-Brunet ,  Vida J. Gorys

    Inventor： Montse Llinas-Brunet ,  Vida J. Gorys

    IPC: A61K3806

    CPC classification number: C07K5/0808 ,  A61K38/00 ,  C07K5/0812 ,  C07K5/0827

    Abstract: Disclosed herein are compounds of formula (1): wherein R1 is hydroxy or NHSO2R1A wherein R1A is (C1-8)alkyl, (C3-7)cycloalkyl or {(C1-6)alkyl-(C3-7)cycloalkyl}, which are all optionally substituted from 1 to 3 times with halo, cyano, nitro, O—(C1-6)alkyl, amido, amino or phenyl, or R1A is C6 or C10 aryl which is optionally substituted from 1 to 3 times with halo, cyano, nitro, (C1-6)alkyl, O—(C1-6) alkyl, amido, amino or phenyl; R2 is (C4-6)cycloalkyl; R3 is t-butyl or (C5-6) cycloalkyl and R4 is (C4-6)cycloalkyl; or a pharmaceutically acceptable salt thereof. The compounds are useful as inhibitors of HCV NS3 protease.

    Abstract translation: 本文公开的是式（1）的化合物：其中R 1是羟基或NHSO 2 R 1A，其中R 1A是（C 1-8）烷基，（C 3-7）环烷基或{（C 1-6）烷基 - （C 3-7）环烷基}，它们都可以任选被卤素，氰基，硝基，O-（C 1-6）烷基，酰胺基，氨基或苯基取代1至3倍，或者R 1A是C 6或C 10芳基 氰基，硝基，（C 1-6）烷基，O-（C 1-6）烷基，酰胺基，氨基或苯基任选被1-3个取代; R 2是（C 4-6）环烷基; R 3是叔丁基或（C 5-6）环烷基，R 4是（C 4-6）环烷基; 或其药学上可接受的盐。 该化合物可用作HCV NS3蛋白酶的抑制剂。

    Macrocyclic peptides active against the hepatitis C virus
    29.
    发明申请
    Macrocyclic peptides active against the hepatitis C virus 审中-公开
    对丙型肝炎病毒有活性的大环肽

    公开(公告)号：US20050075279A1

    公开(公告)日：2005-04-07

    申请号：US10686755

    申请日：2003-10-16

    Applicant: Montse Llinas-Brunet ,  Murray Bailey

    Inventor： Montse Llinas-Brunet ,  Murray Bailey

    IPC: A61K38/00 ,  A61K38/12 ,  C07K5/08

    CPC classification number: C07K5/0802 ,  A61K38/00

    Abstract: Compounds of formula (I): wherein R1 is (C1-8)alkyl, (C3-7)cycloalkyl, {(C1-6)alkyl-(C3-7)cycloalkyl} or Het, which are all optionally substituted from 1 to 3 times with halo, cyano, nitro, O—(C1-6)alkyl, amido, amino or phenyl, or R1 is C6 or C10 aryl which is optionally substituted from 1 to 3 times with halo, cyano, nitro, (C1-6)alkyl, O—(C1-6)alkyl, amido, amino or phenyl; or a pharmaceutically acceptable salt thereof, useful as an inhibitor of the HCV NS3 protease.

    Abstract translation: 式（I）化合物：其中R 1为（C 1-8）烷基，（C 3-7）环烷基，{（C 1-6）烷基 - （C 3-7）环烷基}或Het， 卤素，氰基，硝基，O-（C 1-6）烷基，酰氨基，氨基或苯基，或R 1是任选被卤素取代1至3次的C 6或C 10芳基，氰基 ，硝基，（C 1-6）烷基，O-（C 1-6）烷基，酰胺基，氨基或苯基; 或其药学上可接受的盐，可用作HCV NS3蛋白酶的抑制剂。

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