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    AUTOMATED BEAM CHECK
    21.
    发明申请
    AUTOMATED BEAM CHECK 审中-公开

    公开(公告)号：US20180102241A1

    公开(公告)日：2018-04-12

    申请号：US15837016

    申请日：2017-12-11

    Applicant: MICROMASS UK LIMITED

    Inventor： David Gordon ,  Daniel James Kenny ,  Howard Read ,  Kate Whyatt

    IPC: H01J49/00

    CPC classification number: H01J49/0009 ,  H01J49/0031 ,  H01J49/10

    Abstract: A method of automatically performing a routine to check the operational state of a mass spectrometer is disclosed wherein the method is performed automatically as a start-up routine upon switching ON the mass spectrometer. The method comprises automatically generating a vacuum within one or more vacuum chambers of a mass spectrometer and automatically generating first ions using an internal ion source, wherein the internal ion source is located within a vacuum chamber of the mass spectrometer or is located within a chamber downstream from an atmospheric pressure interface, and detecting at least some of the first ions or second ions derived from the first ions. The method further comprises automatically determining whether or not the mass spectrometer is in a correct operational state.

    Mass Spectrometer Device and Method Using Scanned Phase Applied Potentials in Ion Guidance
    27.
    发明申请
    Mass Spectrometer Device and Method Using Scanned Phase Applied Potentials in Ion Guidance 有权
    质谱仪器和方法使用扫描相应用电离离子指导

    公开(公告)号：US20160163525A1

    公开(公告)日：2016-06-09

    申请号：US15042245

    申请日：2016-02-12

    Applicant: Micromass UK Limited

    Inventor： Martin Raymond Green ,  Jason Lee Wildgoose ,  Steven Derek Pringle ,  Daniel James Kenny

    IPC: H01J49/06 ,  H01J49/36 ,  H01J49/42 ,  H01J49/00

    CPC classification number: H01J49/065 ,  H01J49/0031 ,  H01J49/022 ,  H01J49/062 ,  H01J49/36 ,  H01J49/4235 ,  Y10T436/24

    Abstract: An ion guide or mass analyser is disclosed comprising a plurality of electrodes having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser. The amplitude or depth of the pseudo-potential barrier is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the ion guide or mass analyser in order to urge ions along the length of the ion guides or mass analyser. The amplitude of the transient DC voltage applied to the electrode may be increased with time so that ions are caused to be emitted from the ion guide or mass analyser in reverse order of their mass to charge ratio.

    Abstract translation: 公开了一种离子导向器或质量分析器，其包括具有孔的多个电极，在使用中离子传播通过该孔。 在离子导向器或质量分析器的出口处产生伪势垒。 伪势垒的幅度或深度与离子的质荷比成反比。 一个或多个瞬态直流电压被施加到离子导向器或质量分析器的电极，以沿着离子导向器或质量分析器的长度推动离子。 施加到电极的瞬态直流电压的幅度可以随时间增加，使得离子从离子导向器或质量分析器以其质荷比的相反顺序被发射。

    Compact Mass Spectrometer
    28.
    发明申请
    Compact Mass Spectrometer 审中-公开
    紧凑型质谱仪

    公开(公告)号：US20160111266A1

    公开(公告)日：2016-04-21

    申请号：US14892406

    申请日：2014-05-29

    Applicant: MICROMASS UK LIMITED

    Inventor： David Gordon ,  Daniel James Kenny

    IPC: H01J49/00 ,  H01J49/24 ,  H01J49/10 ,  H01J49/06

    CPC classification number: H01J49/0013 ,  H01J49/062 ,  H01J49/10 ,  H01J49/24

    Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ≦400 mm. The product of the pressure P1 in the vicinity of the first RF ion guide and the length L1 of the first RF ion guide is in the range 10-100 mbar-cm and the product of the pressure P2 in the vicinity of the second RF ion guide and the length L2 of the second RF ion guide is in the range 0.05-0.3 mbar-cm.

    Abstract translation: 公开了一种微型质谱仪，其包括大气压电离源，具有大气压采样孔或毛细管的第一真空室，位于第一真空室下游的第二真空室和位于第二真空室下游的第三真空室。 离子检测器位于第三真空室中。 第一RF离子引导件位于第一真空室内，第二RF离子导向器位于第二真空室内。 从大气压采样孔或毛细管到离子检测器的离子检测表面的离子路径长度为400毫米。 第一RF离子导向器附近的压力P1与第一RF离子导向件的长度L1的乘积在10-100mbar-cm的范围内，第二RF离子附近的压力P2的乘积 引导件，第二RF离子导向件的长度L2在0.05-0.3毫巴-cm的范围内。

    Compact Mass Spectrometer
    29.
    发明申请
    Compact Mass Spectrometer 有权
    紧凑型质谱仪

    公开(公告)号：US20160093479A1

    公开(公告)日：2016-03-31

    申请号：US14892360

    申请日：2014-05-29

    Applicant: MICROMASS UK LIMITED

    Inventor： David Gordon ,  Daniel James Kenny

    IPC: H01J49/00 ,  H01J49/10 ,  H01J49/40

    CPC classification number: H01J49/0013 ,  H01J49/0031 ,  H01J49/062 ,  H01J49/10 ,  H01J49/145 ,  H01J49/24 ,  H01J49/40

    Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source and a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ≦400 mm. The mass spectrometer further comprises a tandem quadrupole mass analyser, a 3D ion trap mass analyser, a 2D or linear ion trap mass analyser, a Time of Flight mass analyser, a quadrupole-Time of Flight mass analyser or an electrostatic mass analyser arranged in the third vacuum chamber. The product of the pressure P1 in the vicinity of the first RF ion guide and the length L1 of the first RF ion guide is in the range 10-100 mbar-cm and the product of the pressure P2 in the vicinity of the second RF ion guide and the length L2 of the second RF ion guide is in the range 0.05-0.3 mbar-cm.

    Abstract translation: 公开了一种微型质谱仪，其包括大气压电离源和具有大气压采样孔或毛细管的第一真空室，位于第一真空室下游的第二真空室和位于第二真空室下游的第三真空室。 离子检测器位于第三真空室中。 第一RF离子引导件位于第一真空室内，第二RF离子导向器位于第二真空室内。 从大气压采样孔或毛细管到离子检测器的离子检测表面的离子路径长度为400毫米。 质谱仪还包括串联四极杆质谱仪，3D离子阱质谱仪，2D或线性离子阱质谱仪，飞行时间质量分析仪，四极杆飞行时间质量分析仪或静电质量分析仪 第三真空室。 第一RF离子导向器附近的压力P1与第一RF离子导向件的长度L1的乘积在10-100mbar-cm的范围内，第二RF离子附近的压力P2的乘积 引导件，第二RF离子导向件的长度L2在0.05-0.3毫巴-cm的范围内。

    Performance Improvements for RF-Only Quadrupole Mass Filters and Linear Quadrupole Ion Traps With Axial Ejection
    30.
    发明申请
    Performance Improvements for RF-Only Quadrupole Mass Filters and Linear Quadrupole Ion Traps With Axial Ejection 有权
    仅用于RF的四极杆质量过滤器和具有轴向喷射的线性四极杆离子阱的性能改进

    公开(公告)号：US20150060658A1

    公开(公告)日：2015-03-05

    申请号：US14534223

    申请日：2014-11-06

    Applicant: Micromass UK Limited

    Inventor： David J. Langridge ,  Daniel James Kenny

    IPC: H01J49/42 ,  H01J49/00

    CPC classification number: H01J49/4215 ,  H01J49/0027 ,  H01J49/06 ,  H01J49/063 ,  H01J49/36 ,  H01J49/422 ,  H01J49/4225

    Abstract: A RF only quadrupole rod set mass filter or mass analyser and a linear quadrupole ion trap with axial ejection are disclosed comprising a first pair of rod electrodes, a second pair of rod electrodes and an energy filter. The first pair of rod electrodes is longer than the second pair of rod electrodes. Ions having desired mass to charge ratios experience fringing fields at an exit region which results in the ions possessing sufficient axial kinetic energy to be transmitted by the energy filter. Other ions possess insufficient axial kinetic energy to be transmitted by the energy filter and are attenuated.

    Abstract translation: 公开了一种射频唯一四极杆组质量过滤器或质量分析器和具有轴向喷射的线性四极离子阱，其包括第一对杆电极，第二对棒电极和能量过滤器。 第一对杆电极比第二对杆电极长。 具有期望的质荷比的离子在出口区域处经历边缘场，导致离子具有足够的轴向动能以被能量过滤器传输。 其他离子具有不足的轴向动能，由能量过滤器传递并被衰减。

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