公开(公告)号：US10206874B2

公开(公告)日：2019-02-19

申请号：US14590432

申请日：2013-07-18

申请人： HETERO RESEARCH FOUNDATION

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Kesireddy Subash Chander Reddy ,  Bandi Vamsi Krishna

IPC分类号： A61K9/10 ,  A61K31/4192 ,  A61K47/38 ,  A61K9/16 ,  A61K47/10 ,  A61K47/32

摘要： The present invention provides a solid dispersion of rufinamide in combination with a pharmaceutically acceptable carrier, process for its preparation and pharmaceutical compositions comprising it.

公开(公告)号：US09815806B2

公开(公告)日：2017-11-14

申请号：US14968034

申请日：2015-12-14

申请人： HETERO RESEARCH FOUNDATION

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Adulla Venkat Narsimha Reddy ,  Bandi Vamsi Krishna

IPC分类号： C07D305/14

CPC分类号： C07D305/14

摘要： The present invention provides an improved process for the preparation of 4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene (7β,10β-dimethoxy-10-deacetoxybaccatin III). The present invention also provides a novel process for the preparation of cabazitaxel.

公开(公告)号：US09518020B2

公开(公告)日：2016-12-13

申请号：US15026694

申请日：2014-09-29

申请人： Hetero Research Foundation

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Thungathurthy Srinivasa Rao ,  Bandi Vamsi Krishna

IPC分类号： C07D213/68 ,  C07D213/81

CPC分类号： C07D213/81 ,  C07B2200/13

摘要： The present invention provides processes for the preparation of i) Regorafenib (4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide, BAY 73-4506, Stivarga®) and its pharmaceutically acceptable salt thereof; ii) a crystalline solid of Regorafenib tosylate; iii) Regorafenib Polymorph I from Regorafenib tosylate, and iv) a pure 4-(4-amino-3-fluorophenoxy)-N-methylpicolinamide from 4-amino-3-fluorophenol and 4-chloro-N-methylpicolinamide in the presence of potassium tert-butoxide.

摘要翻译： 本发明提供了制备i）雷卡非尼（4- [4 - （{[4-氯-3-（三氟甲基）苯基]氨基甲酰基}氨基）-3-氟苯氧基] -N-甲基吡啶-2-甲酰胺的方法， BAY 73-4506，Stivarga？）及其药学上可接受的盐; ii）瑞波非尼甲苯磺酸盐的结晶固体; iii）从罗非拉布甲苯磺酸盐获得的瑞考非非多晶型I，和iv）在钾存在下，由4-氨基-3-氟苯酚和4-氯-N-甲基吡啶酰胺制得纯的4-（4-氨基-3-氟苯氧基）-N-甲基吡啶酰胺 叔丁醇盐。

公开(公告)号：US20150290199A1

公开(公告)日：2015-10-15

申请号：US14589495

申请日：2013-07-08

申请人： Bandi PARTHASARADHI ,  Kura RATHNAKAR REDDY ,  Dasari MURALIDHARA REDDY ,  Kesireddy SUBASH CHANDER REDDY ,  Bandi VAMSI KRISHNA ,  HETERO RESEARCH FOUNDATION

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Kesireddy Subash Chander Redd ,  Bandi Vamsi Krishna

IPC分类号： A61K31/522 ,  A61K9/14

CPC分类号： A61K31/522 ,  A61K9/146

摘要： The present invention provides a novel amorphous solid dispersion of linagliptin in combination with a pharmaceutically acceptable carrier, process for its preparation and pharmaceutical compositions comprising it.

摘要翻译： 本发明提供了一种与药学上可接受的载体组合的利拉格列汀的新型无定形固体分散体，其制备方法和包含其的药物组合物。

公开(公告)号：US20150183751A1

公开(公告)日：2015-07-02

申请号：US14589622

申请日：2013-07-08

申请人： HETERO RESEARCH FOUNDATION

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Adulla Venkat Narsimha Reddy ,  Bandi Vamsi Krishna

IPC分类号： C07D239/48 ,  C07D239/42

CPC分类号： C07D239/48 ,  C07D239/42

摘要： The present invention provides a commercially viable process for preparing rilpivirine and its pharmaceutically acceptable acid addition salts thereof in high yields using novel intermediate.

摘要翻译： 本发明提供了使用新型中间体以高产率制备利比利林及其药学上可接受的酸加成盐的商业上可行的方法。

公开(公告)号：US20150182458A1

公开(公告)日：2015-07-02

申请号：US14590432

申请日：2013-07-18

申请人： HETERO RESEARCH FOUNDATION

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Kesireddy Subash Chander Reddy ,  Bandi Vamsi Krishna

IPC分类号： A61K9/10 ,  A61K47/10 ,  A61K47/32 ,  A61K31/4192 ,  A61K47/38

CPC分类号： A61K9/10 ,  A61K9/1635 ,  A61K9/1641 ,  A61K9/1652 ,  A61K9/1694 ,  A61K31/4192 ,  A61K47/10 ,  A61K47/32 ,  A61K47/38

摘要： The present invention provides a solid dispersion of rufinamide in combination with a pharmaceutically acceptable carrier, process for its preparation and pharmaceutical compositions comprising it.

摘要翻译： 本发明提供了与药学上可接受的载体，其制备方法和包含它的药物组合物的rufinamide的固体分散体。

公开(公告)号：US10442769B2

公开(公告)日：2019-10-15

申请号：US15882317

申请日：2018-01-29

申请人： HETERO RESEARCH FOUNDATION

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dsari Muralidhara Reddy ,  Mogili Narsingam ,  Bandi Vamsi Krishna

IPC分类号： C07C231/02 ,  C07D213/14 ,  C07D213/69 ,  C07D213/79 ,  C07D213/80 ,  C07D213/81 ,  C07D213/82 ,  C07D309/40 ,  C07D498/12

摘要： The present invention provides a novel processes for preparation of methyl 3-(benzyloxy)-5-(2,4-difluorobenzylcarbamoyl)-4-oxo-1-(2-oxoethyl)-1,4-dihydropyiridine-2-carboxylate using novel intermediates.

公开(公告)号：US10023526B2

公开(公告)日：2018-07-17

申请号：US15524391

申请日：2015-11-04

申请人： HETERO RESEARCH FOUNDATION

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Bandi Vamsi Krishna ,  Jambula Mukunda Reddy

IPC分类号： C07C231/02 ,  C07C231/12 ,  C07D211/58 ,  C07C67/293 ,  C07C69/157 ,  C07C51/367 ,  C07C62/32

摘要： The present invention relates to a process for preparing Lomitapide or its pharmaceutically acceptable salt thereof having high purity with acceptable levels of impurities.

公开(公告)号：US09963430B2

公开(公告)日：2018-05-08

申请号：US14968088

申请日：2015-12-14

申请人： HETERO RESEARCH FOUNDATION

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Mogili Narsingam ,  Bandi Vamsi Krishna

IPC分类号： C07D213/02 ,  C07D213/79 ,  C07D213/82 ,  C07C231/02 ,  C07D213/14

CPC分类号： C07D213/82 ,  C07C231/02 ,  C07D213/14 ,  C07D213/69 ,  C07D213/79 ,  C07D213/80 ,  C07D213/81 ,  C07D309/40 ,  C07D498/12

摘要： The present invention provides a novel processes for preparation of methyl 3-(benzyloxy)-5-(2,4-difluorobenzylcarbamoyl)-4-oxo-1-(2-oxoethyl)-1,4-dihydropyiridine-2-carboxylate using novel intermediates.

公开(公告)号：US09624207B2

公开(公告)日：2017-04-18

申请号：US14416324

申请日：2013-07-19

申请人： HETERO RESEARCH FOUNDATION

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Matta Ramakrishna Reddy ,  Bandi Vamsi Krishna

IPC分类号： C07D413/10 ,  C07D413/14 ,  A61K31/4245 ,  B01F3/08 ,  B01F11/00 ,  B01F15/00 ,  B01F15/02 ,  C12M1/33 ,  G01N1/38

CPC分类号： C07D413/10 ,  A61K31/4245 ,  B01F3/0807 ,  B01F11/0028 ,  B01F15/00331 ,  B01F15/00389 ,  B01F15/00396 ,  B01F15/00538 ,  B01F15/026 ,  B01F2215/0073 ,  C07B2200/13 ,  C07D413/14 ,  C12M45/02 ,  G01N1/38

摘要： The present invention provides a novel amorphous Form of azilsartan acid, process for its preparation and pharmaceutical compositions comprising it. The present invention also provides novel crystalline Forms of azilsartan medoxomil, processes for their preparations and pharmaceutical compositions comprising them. The present invention further provides a novel amorphous Form of azilsartan medoxomil potassium, process for its preparation and pharmaceutical compositions comprising it. The present invention further provides a novel process for the preparation of azilsartan medoxomil potassium crystalline Form II.