公开(公告)号：US11116840B2

公开(公告)日：2021-09-14

申请号：US15789670

申请日：2017-10-20

Applicant: Genentech, Inc.

Inventor： Paul Carter ,  Christoph Spiess ,  Yiyuan Yin ,  Jianhui Zhou ,  Wendy Sandoval ,  Jacob Corn ,  Michael Dillon

IPC: A61K39/44 ,  C07K16/46 ,  A61K39/395 ,  G16B5/00 ,  G16B20/00 ,  A61K39/00 ,  G01N33/68

Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

公开(公告)号：US10882921B2

公开(公告)日：2021-01-05

申请号：US16284774

申请日：2019-02-25

Applicant: GENENTECH, INC.

Inventor： Yongmei Chen ,  James Ernst ,  Hok Seon Kim ,  Junichiro Sonoda ,  Christoph Spiess ,  Scott Stawicki ,  Yan Wu

IPC: C12N5/10 ,  C07K16/40 ,  C07K14/71 ,  C07K16/28 ,  A61K39/00

Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.

公开(公告)号：US10662254B2

公开(公告)日：2020-05-26

申请号：US15967154

申请日：2018-04-30

Applicant: GENENTECH, INC.

Inventor： Yu-Ju G. Meng ,  Hok Seon Kim ,  Ingrid Kim ,  Christoph Spiess

IPC: C07K16/42

Abstract: The instant disclosure provides antibody fragments (e.g., Fab and F(ab′)2) having reduced or no reactivity towards pre-existing anti-hinge antibodies (AHA) and compositions comprising such antibody fragments, as well as methods of making and using such antibody fragments and compositions.

公开(公告)号：US20180105605A1

公开(公告)日：2018-04-19

申请号：US15837801

申请日：2017-12-11

Applicant: Genentech, Inc.

Inventor： Yongmei Chen ,  James Ernst ,  Hok Seon Kim ,  Junichiro Sonoda ,  Christoph Spiess ,  Scott Stawicki ,  Yan Wu

IPC: C07K16/40 ,  C07K14/71 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K14/71 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/40 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/524 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/71 ,  C07K2317/75 ,  C07K2317/92

Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.

公开(公告)号：US20160207995A1

公开(公告)日：2016-07-21

申请号：US14858251

申请日：2015-09-18

Applicant: Genentech, Inc.

Inventor： Daniel G. Yansura ,  Nancy Y. Chiang ,  Mark S. Dennis ,  Michael Dillon ,  Germaine G. Fuh ,  Gerald R. Nakamura ,  Christoph Spiess ,  Lawren C. Wu ,  Yin Zhang

IPC: C07K16/24 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/247 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K16/244 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention provides anti-IL-4 antibodies and bispecific antibodies and methods of using the same.

Abstract translation: 本发明提供抗IL-4抗体和双特异性抗体及其使用方法。

公开(公告)号：US20150218276A1

公开(公告)日：2015-08-06

申请号：US14582100

申请日：2014-12-23

Applicant: GENENTECH, INC.

Inventor： Yongmei Chen ,  James Ernst ,  Hok Seon Kim ,  Junichiro Sonoda ,  Christoph Spiess ,  Scott Stawicki ,  Yan Wu

IPC: C07K16/28

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K14/71 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/40 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/524 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/71 ,  C07K2317/75 ,  C07K2317/92

Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.

Abstract translation: 目前公开的主题提供了结合KLB和FGFR1的抗体及其使用方法。 在某些实施方案中，本公开的抗体包括结合存在于FGFR1上并与KLB上存在的表位结合的双特异性抗体。