公开(公告)号：US20170114049A1

公开(公告)日：2017-04-27

申请号：US15300421

申请日：2015-03-31

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Hartmut BECK ,  Volkhart Min-Jian LI ,  Yolanda CANCHO GRANDE ,  Andreas TIMMERMANN ,  Dirk BROHM ,  Hannah JÖRISSEN ,  Pamela BOGNER ,  Michael GERISCH ,  Dieter LANG

IPC分类号： C07D405/12 ,  A61K45/06 ,  A61K47/26 ,  A61K9/00 ,  A61K9/08 ,  A61K47/10 ,  A61K31/53 ,  A61K9/20

CPC分类号： C07D405/12 ,  A61K9/0053 ,  A61K9/08 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2059 ,  A61K31/53 ,  A61K45/06 ,  A61K47/10 ,  A61K47/26 ,  C07D253/08

摘要： The present application relates to novel 2,5-disubstituted cyclopentanecarboxylic acid derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory, pulmonary and cardiovascular disorders.

公开(公告)号：US20160304491A1

公开(公告)日：2016-10-20

申请号：US15106283

申请日：2014-12-16

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Eva Maria BECKER-PELSTER ,  Philipp BUCHGRABER ,  Anja BUCHMÜLLER ,  Karen ENGEL ,  Volker GEISS ,  Andreas GÖLLER ,  Herbert HIMMEL ,  Raimund KAST ,  Andreas KNORR ,  Dieter LANG ,  Gorden REDLICH ,  Carsten SCHMECK ,  Hanna TINEL ,  Frank WUNDER

IPC分类号： C07D401/14 ,  A61K31/506 ,  A61K31/4725 ,  C07D495/10 ,  C07D491/107 ,  C07D413/14 ,  A61K31/5377 ,  A61K45/06 ,  A61K31/541

CPC分类号： C07D401/14 ,  A61K31/4725 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D413/14 ,  C07D491/107 ,  C07D495/10

摘要： The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.

摘要翻译： 本申请涉及新的取代的哌啶基四氢喹啉，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/ /或预防糖尿病性微血管病，四肢糖尿病性溃疡，特别是促进糖尿病足溃疡的伤口愈合，糖尿病性心力衰竭，糖尿病性冠状动脉微血管性心脏病，外周和心脏血管疾病，血栓栓塞性疾病和局部缺血，外周循环障碍，雷诺 现象，CREST综合征，微循环障碍，间歇性跛行，外周和自主神经病变。

公开(公告)号：US20160145271A1

公开(公告)日：2016-05-26

申请号：US14903347

申请日：2014-07-08

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Alexandros VAKALOPOULOS ,  Alexey GROMOV ,  Markus FOLLMANN ,  Damian BROCKSCHNIEDER ,  Johannes-Peter STASCH ,  Tobias MARQUARDT ,  Adrian TERSTEEGEN ,  Frank WUNDER ,  Gorden REDLICH ,  Dieter LANG ,  Volkhart Min-Jian LI

IPC分类号： C07D519/00 ,  A61K45/06 ,  A61K31/53

CPC分类号： C07D519/00 ,  A61K31/53 ,  A61K45/06 ,  C07D519/04

摘要： The present application relates to novel benzyl-1H-pyrazolo[3,4-b]pyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

摘要翻译： 本申请涉及新的苄基-1H-吡唑并[3,4-b]吡啶，其制备方法，单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。

公开(公告)号：US20140031391A1

公开(公告)日：2014-01-30

申请号：US13945675

申请日：2013-07-18

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Michael HAHN ,  Markus FOLLMANN ,  Walter HÜBSCH ,  Eva-Maria BECKER ,  Johannes-Peter STASCH ,  Joerg KELDENICH ,  Martina DELBECK ,  Hanna TINEL ,  Frank WUNDER ,  Joachim MITTENDORF ,  Ildiko TEREBESI ,  Dieter LANG ,  René MARTIN

IPC分类号： C07D215/48 ,  C07D401/12 ,  A61K45/06 ,  A61K31/4706 ,  A61K31/4709 ,  C07D413/12

CPC分类号： C07D215/48 ,  A61K31/47 ,  A61K31/4706 ,  A61K31/4709 ,  A61K45/06 ,  C07D217/26 ,  C07D401/12 ,  C07D413/12

摘要： The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.

摘要翻译： 本申请涉及新的5-氨基-5,6,7,8-四氢喹啉-2-羧酸，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产 用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管和心肺疾病的药物。