公开(公告)号：US11648583B2

公开(公告)日：2023-05-16

申请号：US16843989

申请日：2020-04-09

Applicant: Alcon Inc.

Inventor： Newton T. Samuel ,  Yongxing Qiu ,  John Dallas Pruitt ,  Matthew McCollum

IPC: B05D1/18 ,  G02B1/18 ,  C09D5/00 ,  C09D133/02 ,  B05D3/02 ,  B05D3/10 ,  G02C7/04

CPC classification number: B05D1/18 ,  B05D3/0209 ,  B05D3/107 ,  C09D5/002 ,  C09D133/02 ,  G02B1/18 ,  B05D2258/00 ,  B05D2401/20 ,  B05D2401/21 ,  B05D2502/00 ,  G02C7/04

Abstract: The invention is generally related to a method for producing, in a consistent manner, contact lenses each having an intact durable coating thereon, wherein the coating is a hydrogel coating formed by covalently attached a hydrophilic polymeric material having azetidinium groups onto a base coating of a polyanionic polymer on a contact lens at a relatively low temperature (e.g., from about 40° C. to about 60° C.). The coating temperature for forming a durable hydrogel coating on top of the base coating of a contact lens can be significantly lowered by raising, in situ, the pH (to about 9.5 or higher) of a reactive coating solution which contains the hydrophilic polymeric material having azetidinium groups.

公开(公告)号：US11534994B2

公开(公告)日：2022-12-27

申请号：US17146181

申请日：2021-01-11

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  Newton T. Samuel ,  John Dallas Pruitt ,  Chandana Kolluru ,  Arturo Norberto Medina ,  Lynn Cook Winterton ,  Daqing Wu ,  Xinming Qian ,  Jared Nelson

IPC: B29D11/00 ,  G02B1/18 ,  G02B1/04 ,  G02C7/04 ,  G02B1/10 ,  C08J7/04 ,  C08L83/04 ,  C08G77/388 ,  C08J5/00 ,  C09D5/16 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02 ,  C09D177/06

Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

公开(公告)号：US10781340B2

公开(公告)日：2020-09-22

申请号：US16582624

申请日：2019-09-25

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Sibichen J. Thekveli ,  Robert Carey Tucker ,  Jared Nelson

IPC: C09D171/02 ,  C09D177/06 ,  B29D11/00 ,  G02B1/04 ,  G02C7/04 ,  G02B1/10 ,  G02B1/18 ,  C08J7/04 ,  C08L83/04 ,  C08G77/388 ,  C08J5/00 ,  C09D5/16 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26

Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.