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公开(公告)号:US11884541B2
公开(公告)日:2024-01-30
申请号:US17727489
申请日:2022-04-22
Applicant: VERO Biotech Inc.
Inventor: David H. Fine , Gregory Vasquez , David P. Rounbehler
IPC: B01D53/02 , C01B21/32 , A61K33/00 , C01B21/24 , A61D7/04 , A61M16/12 , A61M16/00 , A61M16/10 , A61M16/16 , G01N27/416
CPC classification number: C01B21/32 , A61D7/04 , A61K33/00 , A61M16/009 , A61M16/0051 , A61M16/0057 , A61M16/104 , A61M16/1075 , A61M16/12 , A61M16/16 , C01B21/24 , G01N27/416 , A61M16/107 , A61M16/1055 , A61M2016/102 , A61M2202/0275 , Y10T436/179228
Abstract: Various systems, devices, NO2 absorbents, NO2 scavengers and NO2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.
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公开(公告)号:US20230398323A1
公开(公告)日:2023-12-14
申请号:US18184847
申请日:2023-03-16
Applicant: VERO BIOTECH INC.
Inventor: David H. FINE , Gregory VASQUEZ , Bryan JOHNSON , Ryan DENTON , Lucas G. GAMERO
CPC classification number: A61M16/122 , A61M16/10 , C01B21/24 , A61M16/12 , A61M16/1055 , A61M16/107 , A61M2205/0238 , A61M16/0666
Abstract: A system for deliverying a therapeutic amount of nitric oxide can include a reservoir assembly, a gas supply, and a delivery conduit including a first cartridge, wherein the first cartridge can include a surface-activated material saturated with an aqueous solution of a reducing agent.
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公开(公告)号:US20230294060A1
公开(公告)日:2023-09-21
申请号:US18059309
申请日:2022-11-28
Applicant: VERO Biotech Inc.
Inventor: David FINE , David Rounbehler , Gregory Vasquez , Bryan Johnson
CPC classification number: B01J12/007 , A61M16/10 , C01B21/24 , A61M16/122 , A61K33/00 , A62B7/08 , A61M2202/0275 , A61M2016/1025 , A61M2202/0007 , A61M2202/0078 , A61M2205/07 , A61M2205/12
Abstract: A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.
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公开(公告)号:US11607520B2
公开(公告)日:2023-03-21
申请号:US16247516
申请日:2019-01-14
Applicant: VERO BIOTECH INC.
Inventor: David H. Fine , Gregory Vasquez , Bryan Johnson , Ryan Denton , Lucas G. Gamero
Abstract: A system for delivering a therapeutic amount of nitric oxide can include a reservoir containing a nitrogen dioxide source. A heating element can be configured to heat the reservoir, causing nitrogen dioxide vapor to exit the reservoir through a restrictor into a conduit. The nitrogen dioxide vapor can mix with gas from a gas supply, which can then flow to a cartridge that includes a surface-activated material saturated with an aqueous solution of a reducing agent. The cartridge can convert the nitrogen dioxide into nitric oxide.
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公开(公告)号:US11554241B2
公开(公告)日:2023-01-17
申请号:US15967209
申请日:2018-04-30
Applicant: VERO Biotech Inc.
Inventor: David R. Rounbehler , David H. Fine
Abstract: A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.
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公开(公告)号:US11312626B2
公开(公告)日:2022-04-26
申请号:US16512021
申请日:2019-07-15
Applicant: VERO Biotech Inc.
Inventor: David H. Fine , Gregory Vasquez , David P. Rounbehler
IPC: B01D53/02 , C01B21/32 , A61K33/00 , C01B21/24 , A61D7/04 , A61M16/12 , A61M16/00 , A61M16/10 , A61M16/16 , G01N27/416
Abstract: Various systems, devices, NO2 absorbents, NO2 scavengers and NO2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.
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公开(公告)号:US12171948B2
公开(公告)日:2024-12-24
申请号:US18353436
申请日:2023-07-17
Applicant: VERO Biotech Inc.
Inventor: David H. Fine , Bryan Johnson , Gregory Vasquez
Abstract: Various systems and devices for generating nitric oxide are disclosed herein. According to one embodiment, the device includes a body having an inlet, an outlet, and a porous solid matrix positioned with the body. The porous solid matrix is coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide. The porous solid matrix allows the device to be used in any orientation. Additionally, the porous solid matrix provides a rigid structure suitable to withstand vibrations and abuse without compromising device functionality.
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公开(公告)号:US20240226490A9
公开(公告)日:2024-07-11
申请号:US18491463
申请日:2023-10-20
Applicant: VERO BIOTECH INC.
Inventor: John MAYNARD , Jason MOLINARI , Lucas G. GAMERO
CPC classification number: A61M16/12 , A61M16/0003 , A61M16/024 , A61M2202/0275
Abstract: Disclosed herein is a system for delivering a nitric oxide to a subject, wherein the system comprises: (a) a nitric oxide injection line configured to inject a first gas at an injection point into a breathing conduit comprising a breathing gas, wherein the first gas comprises a first amount of nitric oxide; (b) a sampling line configured to sample a second gas comprising a second amount of nitric oxide and the breathing gas at a sampling location between the injection point of the first gas and a subject and (c) a feedback-loop controller that is in communication with: (i) a nitric oxide set-point controller configured to set a nitric oxide set-point amount; (ii) a source configured to provide a third gas having a third amount of nitric oxide; and (iii) at least one sensor configured to measure the second amount of nitric oxide in the sampling line.
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公开(公告)号:US20240082530A1
公开(公告)日:2024-03-14
申请号:US18353436
申请日:2023-07-17
Applicant: VERO Biotech Inc.
Inventor: David H. FINE , Bryan JOHNSON , Gregory VASQUEZ
CPC classification number: A61M16/12 , A61M16/10 , A61M16/104 , A61M16/107 , A61M16/1075 , A61M16/109 , A61M16/16 , A62B7/08 , A62B21/00 , A61M2202/0275
Abstract: Various systems and devices for generating nitric oxide are disclosed herein. According to one embodiment, the device includes a body having an inlet, an outlet, and a porous solid matrix positioned with the body. The porous solid matrix is coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide. The porous solid matrix allows the device to be used in any orientation. Additionally, the porous solid matrix provides a rigid structure suitable to withstand vibrations and abuse without compromising device functionality.
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公开(公告)号:US20230414896A1
公开(公告)日:2023-12-28
申请号:US18310152
申请日:2023-05-01
Applicant: VERO Biotech Inc.
Inventor: David H. FINE , Edward BROMBERG , Ryan DENTON , Jason WHITE , Lucas G. GAMERO , Bryan JOHNSON , Gregory VASQUEZ , Doug SONOSKY
CPC classification number: A61M16/122 , A61M16/0057 , A61M2202/0275 , A61M2205/3368 , A61M2205/6018 , A61M2202/0208 , A61M16/0666
Abstract: Start-up protocols for a device and method for administering NO is described.
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