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公开(公告)号：US20180016301A1
公开(公告)日：2018-01-18
申请号：US15436214
申请日：2017-02-17
申请人： Trevena, Inc.
发明人： Nhut K. Diep , Yuriy Kalyan , Graham Lawton , Matthew Ronsheim , Shao Hong Zhou , Saibaba Racha
摘要： Embodiments disclosed herein provide compounds and methods for preparing Beta-Arrestin Effectors.
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公开(公告)号：US20150246904A1
公开(公告)日：2015-09-03
申请号：US14712974
申请日：2015-05-15
申请人： Trevena, Inc.
发明人： Dennis Yamashita , Dimitar Gotchev , Philip Pitis , Xiao-Tao Chen , Guodong Liu , Catherine C.K. Yuan
IPC分类号： C07D409/14
CPC分类号： A61K31/4436 , A61K9/0019 , A61K31/35 , A61K31/4433 , A61K31/444 , A61K45/06 , C07D311/96 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
摘要： This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.
摘要翻译： 本申请描述了可以作为阿片受体配体的化合物，该化合物可用于治疗例如疼痛和疼痛相关疾病。
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公开(公告)号：US20150225461A1
公开(公告)日：2015-08-13
申请号：US14616487
申请日：2015-02-06
申请人： Trevena, Inc.
发明人： Ritesh Sanghvi , Gregory Alcorn , Graham Richard Lawton , Meiki Yu , Matthew Ronsheim , Jiaher Tian , Shao Hong Zhou , Yuriy B. Kalyan
摘要： The present disclosure provides novel crystalline forms of a compound that acts as a β-arrestin effector, processes for preparing novel crystalline and amorphous forms of a compound that acts as a β-arrestin effector and uses thereof
摘要翻译： 本公开提供了用作“ - ”的效应物的化合物的新型结晶形式，用于制备新颖的结晶和无定形形式的化合物，其作为一种“ - 甲氨蝶呤”效应物及其用途
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公开(公告)号：US08809260B2
公开(公告)日：2014-08-19
申请号：US13925170
申请日：2013-06-24
申请人： Trevena, Inc.
发明人： Dennis Yamashita , Xiao-Tao Chen
摘要： This application describes a family of compounds acting as β-arrestin effectors. Such compounds may provide significant therapeutic benefit in the treatment of chronic and acute cardiovascular diseases.
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公开(公告)号：US11884655B2
公开(公告)日：2024-01-30
申请号：US17099895
申请日：2020-11-17
申请人： Trevena, Inc.
IPC分类号： C07D413/14
CPC分类号： C07D413/14 , C07B2200/13
摘要： The present embodiments are directed, in part, to processes and compositions that can, for example, be used in the preparation compounds of Formula (I), or a pharmaceutically acceptable salts thereof.
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公开(公告)号：US20230234946A1
公开(公告)日：2023-07-27
申请号：US18296018
申请日：2023-04-05
申请人： Trevena, Inc.
发明人： Philip Michael Pitis , Robert Eugene Boyd , Tamara Ann Miskowski Daubert , Michael John Hawkins , Guodong Liu , Aimee Crombie Speerschneider
IPC分类号： C07D413/04 , A61P25/02 , A61P35/00 , C07D413/14 , C07D405/14
CPC分类号： C07D413/04 , A61P25/02 , A61P35/00 , C07D413/14 , C07D405/14
摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of S1P1 receptor and methods of using the same.
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公开(公告)号：US20230114241A1
公开(公告)日：2023-04-13
申请号：US17639401
申请日：2020-09-03
申请人： Trevena, Inc.
IPC分类号： A61K31/4245 , A61K31/4439 , A61K31/497 , A61K31/433 , A61K31/427 , A61K31/4709 , A61K31/437 , A61K31/444 , A61K31/4192 , A61K31/4725 , A61K31/506 , A61K31/498 , A61P25/08
摘要： The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of S1P1 receptor and methods of using the same for the treatment of seizures, epilepsy related conditions, epilepsy-related syndrome, and the like as described herein.
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公开(公告)号：US20210324005A1
公开(公告)日：2021-10-21
申请号：US17235254
申请日：2021-04-20
申请人： Trevena, Inc.
发明人： Mark A. Demitrack
摘要： This application describes a family of compounds acting as β-arrestin effectors that can be used, for example, for treating acute respiratory distress syndrome, for preventing and treating thrombosis, platelet adhesion, and platelet aggregation, and/or for reducing a D-Dimer response, in a subject with ARDS or a viral infection, such as a coronavirus infection.
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公开(公告)号：US11077098B2
公开(公告)日：2021-08-03
申请号：US15828695
申请日：2017-12-01
申请人： TREVENA, INC.
发明人： Dennis Yamashita , Dimitar Gotchev , Philip Pitis , Xiao-Tao Chen , Guodong Liu , Catherine C. K. Yuan
IPC分类号： A61K31/4436 , A61K9/00 , A61K45/06 , A61K31/444 , A61K31/4433 , A61K31/35 , C07D409/14 , C07D405/14 , C07D405/12 , C07D405/04 , C07D311/96 , C07D409/12
摘要： This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.
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公开(公告)号：US20210147402A1
公开(公告)日：2021-05-20
申请号：US17099895
申请日：2020-11-17
申请人： Trevena, Inc.
IPC分类号： C07D413/14
摘要： The present embodiments are directed, in part, to processes and compositions that can, for example, be used in the preparation compounds of Formula (I), or a pharmaceutically acceptable salts thereof.
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