公开(公告)号：US20220135688A1

公开(公告)日：2022-05-05

申请号：US17488811

申请日：2021-09-29

申请人： Medizinische Hochschule Hannover ,  Technische Universität Braunschweig

发明人： Elmar Jäckel ,  Fatih Noyan ,  Michael Hust

IPC分类号： C07K16/28 ,  C07K14/47

摘要： A fusion protein for use in the treatment of HvG disease in a patient having received a transplant, for use in suppressing the host's immune response directed against the transplant. The fusion protein is adapted for use in suppressing the immune rejection of a transplant which contains or expresses HLA-A*02 or SLA-01*0401 in a recipient patient who is negative for HLA-A*02 or SLA-01*0401, i.e. the patient prior to transplantation does not express HLA-A*02 or SLA-01*0401. The fusion protein is a chimeric antigen receptor (CAR), which upon expression in regulatory T-cells (Treg) causes a specific suppressor activity of the regulatory T-cells in the presence of HLA-A*02 or SLA-01*0401.

公开(公告)号：US20220109086A1

公开(公告)日：2022-04-07

申请号：US16978641

申请日：2018-03-07

申请人： Photonik Inkubator GmbH ,  Technische Universität Braunschweig Körperschaft Des Öffentlichen Rechts

发明人： Sönke Fündling ,  Frederik Steib ,  Andreas Waag

IPC分类号： H01L33/38 ,  H01L33/00 ,  H01L33/44 ,  H01L33/30 ,  H01L33/32 ,  H01L27/15

摘要： A semiconductor device for emitting electromagnetic radiation, and to a method of producing the same, which can be used as a semiconductor-based, structured light source. The semiconductor device comprises a layer stack structure composed of an n-doped layer, an active layer and a p-doped layer, as well as a connection structure comprising conductor layers and at least one insulator layer, the conductor layers being arranged, parallel to and spaced apart from one another, along a first direction that is parallel to the active layer of the layer stack structure, and at least one insulator layer being arranged between at least two conductor layers, one or more conductor layers being electrically connected to the p-doped layer of the layer stack structure.

公开(公告)号：US20200183745A1

公开(公告)日：2020-06-11

申请号：US16638098

申请日：2018-08-10

申请人： TTZ EMBEDDED SYSTEMS INNOVATIONSGESELLSCHAFT TECHNISCHE UNIVERSITÄT BRAUNSCHWEIG MBH

发明人： Rolf ERNST ,  Adam KOSTRZEWA ,  Sebastian TOBUSCHAT

IPC分类号： G06F9/50

摘要： Suggested are methods and devices for dynamic resource allocation in a multiprocessor computer system with a plurality of components. The method comprises different steps, such as receiving a request for access to a shared resource, wherein after the allocation of the requested shared resource to the requesting unit, a prescribed real-time requirement is to be ensured by the multiprocessor computer system. Based on the operating parameters determined for a design time of the multiprocessor computer system and current operating parameters, future operating parameters to be expected after an allocation of the requested shared resource are determined. If the prescribed real-time requirement operating parameters is to be ensured in the future, the requested resource is allocated to the requesting unit.

公开(公告)号：US20200059439A1

公开(公告)日：2020-02-20

申请号：US16611109

申请日：2018-04-20

申请人： TECHNISCHE UNIVERSITÄT BRAUNSCHWEIG

发明人： Adam KOSTRZEWQ ,  Sebastian TOBUSCHAT ,  Rolf ERNST

IPC分类号： H04L12/911 ,  H04L12/923 ,  G06F9/455

摘要： The invention relates to a method for coordinating access to a resource of a distributed computer system, which has a plurality of distributed client stations, wherein there are at least two client stations, each having at least one computer, at least one resource of the computer system, at least one resource manager, which is designed to manage the resources of the computer system assigned thereto, and at least one internal communication medium, via which the at least one computer, the at least one resource and the at least one resource manager are coupled, client-station-internally, for carrying out data communication, wherein the client stations are coupled to each other via at least one external communication medium in order to carry out data communication. According to the invention, the client stations can communicate among each other. The invention furthermore relates to a computer system of this kind and a computer program for carrying out the method.

公开(公告)号：US20190290691A1

公开(公告)日：2019-09-26

申请号：US16310312

申请日：2017-06-22

申请人： MEDIZINISCHE HOCHSCHULE HANNOVER ,  TECHNISCHE UNIVERSITÄT BRAUNSCHWEIG

发明人： Elmar Jäckel ,  Fatih Noyan ,  Michael Hust

IPC分类号： A61K35/17 ,  C07K14/725 ,  C07K16/28 ,  A61P37/06 ,  C07K19/00 ,  C12N15/85

摘要： The invention provides a fusion protein for use in the treatment of HvG disease in a patient having received a transplant, for use in suppressing the host's immune response directed against the transplant. The fusion protein is adapted for use in suppressing the immune rejection of a transplant which contains or expresses HLA-A*02 or SLA-01*0401 in a recipient patient who is negative for HLA-A*02 or SLA-01*0401, i.e. the patient prior to transplantation does not express HLA-A*02 or SLA-01*0401. The fusion protein is a chimeric antigen receptor (CAR), which upon expression in regulatory T-cells (Treg) causes a specific suppressor activity of the regulatory T-cells in the presence of HLA-A*02 or SLA-01*0401.

公开(公告)号：US09543086B2

公开(公告)日：2017-01-10

申请号：US14652971

申请日：2013-12-20

申请人： TECHNISCHE UNIVERSITÄT BRAUNSCHWEIG

发明人： Vladimir Ermel ,  Michael Kurrat

IPC分类号： H01H9/36 ,  H01H23/08 ,  H01H33/10 ,  H01H33/16 ,  H01H33/20 ,  H01H33/59 ,  H01H33/664 ,  H01H33/08

CPC分类号： H01H9/36 ,  H01H33/08 ,  H01H33/10 ,  H01H33/164 ,  H01H33/20 ,  H01H33/596 ,  H01H33/664 ,  H01H33/6647

摘要： The invention relates to a power circuit breaker that is suitable for switching electrical voltages. The power circuit breaker according to the invention comprises two main electrodes, to each of which a respective pole of the voltage to be switched can be connected. During the switching process, at least one of said main electrodes follows a switching path. The power circuit breaker is characterized in that secondary electrodes are additionally provided, which protrude into the vicinity of the switching path and are designed and arranged in such a way that arcs can be produced (a) between the main electrodes and the secondary electrodes and (b) between the individual secondary electrodes during the switching process. The power circuit breaker according to the invention can be advantageously used in vehicles and in ultra-high-voltage AC and HVDC (high-voltage direct current) transmission systems and causes arcs to be extinguished as early as possible during the switching process.

摘要翻译： 本发明涉及一种适用于切换电压的电源断路器。 根据本发明的电源断路器包括两个主电极，每个主电极可以连接要切换的电压的相应极点。 在切换过程中，至少一个所述主电极跟随切换路径。 电源断路器的特征在于，另外设置有二次电极，其突出到开关路径附近，并且被设计和布置成使得可以在主电极和次电极之间产生电弧（a）和（ b）在切换过程中各个次级电极之间。 根据本发明的电力断路器可以有利地用于车辆和超高压AC和HVDC（高压直流）传输系统中，并且在切换过程中尽可能早地熄灭电弧。