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    Probes and detection method for a human interferon-inducible protein
    21.
    发明授权
    Probes and detection method for a human interferon-inducible protein 失效
    人干扰素诱导蛋白的探针和检测方法

    公开(公告)号：US5977338A

    公开(公告)日：1999-11-02

    申请号：US966444

    申请日：1997-11-07

    Applicant: Jennifer L. Hillman ,  Phillip R. Hawkins

    Inventor： Jennifer L. Hillman ,  Phillip R. Hawkins

    IPC: G01N33/53 ,  A61K38/00 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07K14/47 ,  C07K14/555 ,  C07K16/24 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12Q1/68 ,  C12N15/11 ,  C12N15/12 ,  C12N15/19

    CPC classification number: C07K14/4718 ,  A61K38/00

    Abstract: The present invention provides a novel human interferon-inducible protein (HIFI) and the polynucleotides which identify and encode HIFI. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HIFI and for a method for producing the protein. The invention also provides pharmaceutical compositions containing HIFI and the use of such compositions for the prevention or treatment of diseases associated with the expression of HIFI. Additionally, the invention provides antisense molecules to HIFI and their use in the treatment of diseases associated with the expression of HIFI. The invention also provides diagnostic assays which utilize polynucleotides which hybridize with naturally occurring sequences encoding HIFI and antibodies which specifically bind to the protein.

    Abstract translation: 本发明提供新型人干扰素诱导蛋白（HIFI）和识别和编码HIFI的多核苷酸。 本发明提供了包含编码HIFI的核酸序列和用于产生蛋白质的方法的遗传工程表达载体和宿主细胞。 本发明还提供含有HIFI的药物组合物和这些组合物用于预防或治疗与HIFI表达有关的疾病的用途。 此外，本发明提供了HIFI的反义分子及其在治疗与HIFI表达相关的疾病中的用途。 本发明还提供利用与编码HIFI的天然存在的序列和与蛋白特异性结合的抗体杂交的多核苷酸的诊断测定。

    Human cAMP-dependent protein kinase inhibitor homolog
    23.
    发明授权
    Human cAMP-dependent protein kinase inhibitor homolog 失效
    人cAMP依赖性蛋白激酶抑制剂同源物

    公开(公告)号：US5922844A

    公开(公告)日：1999-07-13

    申请号：US892150

    申请日：1997-07-14

    Applicant: Phillip R. Hawkins ,  Jennifer L. Hillman ,  Janice Au-Young

    Inventor： Phillip R. Hawkins ,  Jennifer L. Hillman ,  Janice Au-Young

    IPC: G01N33/53 ,  A61K31/711 ,  A61K38/00 ,  A61K38/55 ,  A61K39/395 ,  A61K48/00 ,  A61P43/00 ,  C07K14/47 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/68 ,  C07K1/00

    CPC classification number: C07K14/4703 ,  A61K38/00

    Abstract: The present invention provides a polynucleotide (ipka) which identifies and encodes a novel human cAMP-dependent protein kinase A inhibitor homolog (IPKA). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding IPKA. The invention also provides for the use of purified IPKA and its agonists in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of IPKA. Additionally, the invention provides for the use of antisense molecules to ipka in pharmaceutical compositions for treatment of diseases associated with the expression of IPKA. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of ipka. The present invention also relates to anti-IPKA antibodies which specifically bind to IPKA.

    Abstract translation: 本发明提供鉴定和编码新的人cAMP依赖性蛋白激酶A抑制剂同源物（IPKA）的多核苷酸（ipka）。 本发明提供了包含编码IPKA的核酸序列的基因工程表达载体和宿主细胞。 本发明还提供纯化的IPKA及其激动剂在商业生产重组蛋白质和用于治疗与IPKA表达相关的疾病的药物组合物中的用途。 另外，本发明提供了用于治疗与IPKA表达相关的疾病的药物组合物中ipka的反义分子的用途。 本发明还描述了使用包含其多核苷酸，其片段或其互补物的诊断组合物的诊断测定法，其与ipka的基因组序列或转录物杂交。 本发明还涉及特异性结合IPKA的抗IPKA抗体。

    Antibodies to a novel tissue inhibitor of metalloproteinases
    24.
    发明授权
    Antibodies to a novel tissue inhibitor of metalloproteinases 失效
    金属蛋白酶新型组织抑制剂的抗体

    公开(公告)号：US5914392A

    公开(公告)日：1999-06-22

    申请号：US111070

    申请日：1998-07-07

    Applicant: Phillip R. Hawkins ,  Lynn E. Murry

    Inventor： Phillip R. Hawkins ,  Lynn E. Murry

    IPC: A61K38/00 ,  C07K14/81 ,  C07K16/38 ,  C07K16/00 ,  A61K39/395

    CPC classification number: C07K16/38 ,  C07K14/8146 ,  A61K38/00

    Abstract: The present invention provides a nucleic acid sequence which identifies and encodes a novel tissue inhibitor of metalloproteinases (TIMP-4) which was isolated from cells of human uterus. The invention provides for TIMP-4 antisense molecules and genetically engineered expression vectors and host cells comprising nucleic acid sequence encoding TIMP-4. The invention also provides for purified TIMP-4; antibodies, antagonists and inhibitors which specifically bind TIMP-4; and pharmaceutical compositions and methods of treatment based on TIMP-4, its antagonists and inhibitors. The invention provides for diagnostic assays which utilize diagnostic compositions comprising nucleic acid sequences encoding to TIMP-4, or complements thereof, and antibodies which specifically bind to TIMP-4.

    Abstract translation: 本发明提供了鉴定和编码从人子宫细胞分离的金属蛋白酶（TIMP-4）的新型组织抑制剂的核酸序列。 本发明提供TIMP-4反义分子和遗传工程改造的表达载体以及包含编码TIMP-4的核酸序列的宿主细胞。 本发明还提供了纯化的TIMP-4; 特异性结合TIMP-4的抗体，拮抗剂和抑制剂; 以及基于TIMP-4，其拮抗剂和抑制剂的药物组合物和治疗方法。 本发明提供了利用包含编码TIMP-4或其互补序列的核酸序列以及特异性结合TIMP-4的抗体的诊断组合物的诊断测定法。

    Human kinase homologs
    25.
    发明授权
    Human kinase homologs 失效
    人类激酶同源物

    公开(公告)号：US5817479A

    公开(公告)日：1998-10-06

    申请号：US700575

    申请日：1996-08-07

    Applicant: Janice Au-Young ,  Olga Bandman ,  Phillip R. Hawkins ,  Craig G. Wilde

    Inventor： Janice Au-Young ,  Olga Bandman ,  Phillip R. Hawkins ,  Craig G. Wilde

    IPC: C12N9/12 ,  C12N15/54 ,  C12P21/06 ,  C12N15/64

    CPC classification number: C12N9/1205

    Abstract: The present invention provides polynucleotides (kin) which identify and encode novel protein kinases (KIN) expressed in various human cells and tissues. The present invention also provides for antisense sequences and oligonucleotides designed from the nucleotide sequences or their complements. The invention further provides genetically engineered expression vectors and host cells for the production of purified KIN peptides, antibodies capable of binding KIN, and inhibitors specifically bind KIN. The invention specifically provides for diagnostic kits and assays which identify a disorder or disease with altered kinase expression and allow monitoring of patients during drug therapy. These assays utilize oligonucleotides or antibodies produced using the kin polynucleotides.

    Abstract translation: 本发明提供鉴定和编码在各种人细胞和组织中表达的新型蛋白激酶（KIN）的多核苷酸（kin）。 本发明还提供了从核苷酸序列或其互补序列设计的反义序列和寡核苷酸。 本发明还提供用于产生纯化的KIN肽，能够结合KIN的抗体和特异性结合KIN的抑制剂的遗传工程表达载体和宿主细胞。 本发明特别提供了用于鉴定具有改变的激酶表达并允许在药物治疗期间监测患者的病症或疾病的诊断试剂盒和测定法。 这些测定法利用使用亲代多核苷酸产生的寡核苷酸或抗体。

    Tissue inhibitor of metalloproteinases
    30.
    发明授权
    Tissue inhibitor of metalloproteinases 失效
    组织金属蛋白酶抑制剂

    公开(公告)号：US5643752A

    公开(公告)日：1997-07-01

    申请号：US588163

    申请日：1996-01-18

    Applicant: Phillip R. Hawkins ,  Lynn E. Murry

    Inventor： Phillip R. Hawkins ,  Lynn E. Murry

    IPC: A61K38/00 ,  C07K14/81 ,  C07K16/38 ,  C12N15/00 ,  C12N15/11 ,  C12N15/63 ,  C12N15/85

    CPC classification number: C07K16/38 ,  C07K14/8146 ,  A61K38/00

    Abstract: The present invention provides a nucleic acid sequence which encodes a novel tissue inhibitor of metalloproteinases (TIMP-4) which was isolated from cells of human uterus. The invention provides for genetically engineered expression vectors and host cells comprising nucleic acid sequence encoding TIMP-4. The invention also provides for purified TIMP-4.

    Abstract translation: 本发明提供了编码从人子宫细胞分离的金属蛋白酶组织抑制剂（TIMP-4）的核酸序列。 本发明提供了基因工程表达载体和包含编码TIMP-4的核酸序列的宿主细胞。 本发明还提供了纯化的TIMP-4。

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