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公开(公告)号：US10994056B2
公开(公告)日：2021-05-04
申请号：US15510106
申请日：2015-09-09
Inventor： Toshiji Mukai , Naoko Ikeo , Eisei Gu , Takumi Fukumoto , Hikaru Yabuuchi
Abstract: A device for fixing biological soft tissue is endowed with strength and deformation performance for being used as a device for coupling biological soft tissue that has been cut or separated due to an incision or the like during a surgical procedure, and is completely degraded in vivo and discharged after adhesion of the soft tissue or after healing of the incision tissue. The device is composed of a ternary Mg alloy material of Mg—Ca—Zn. In the Mg alloy material, the Ca and Zn are contained within the solid-solubility limit with respect to the Mg. The remainder is composed of Mg and unavoidable impurities. The Zn content is 0.5 at % or less. The Ca and Zn content has a relationship of Ca:Zn=1:x (where x is 1 to 3) by atom ratio. The crystal grain structure is equiaxed, the crystal grain size according to linear intercept being 30 to 250 μm.
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22.发明申请公开(公告)号：US20210115287A1
公开(公告)日：2021-04-22
申请号：US17056819
申请日：2019-06-05
Inventor： Masanori Nishiyama , Ichiro Tomari , Ryo Yamane , Hideyuki Suzuki , Koji Kuraoka
Abstract: The object of the present invention is to provide a coating agent for forming a coating film having barrier properties and stretchability and to provide a resin container comprising a coating film formed using the coating agent on a surface thereof, wherein the coating film has high barrier properties and is less prone to film breakage during stretching.
LDH, which is in the form of nanometer-scale particles, is added along with PVA.-
公开(公告)号：US20200377910A1
公开(公告)日：2020-12-03
申请号：US16094587
申请日：2017-04-21
Inventor： Keiji NISHIDA , Akihiko KONDO , Takayuki ARAZOE , Zenpei SHIMATANI
Abstract: The present invention provides a method of modifying a targeted site of a double-stranded DNA, comprising a step of introducing a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a double-stranded DNA and PmCDA1 are bonded, into a cell containing the double-stranded DNA, and culturing the cell at a low temperature at least temporarily to convert the targeted site, i.e., the target nucleotide sequence and nucleotides in the vicinity thereof, to other nucleotides, or delete the targeted site, or insert nucleotide into the site.
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公开(公告)号：US20200080080A1
公开(公告)日：2020-03-12
申请号：US16467224
申请日：2017-12-25
Inventor： Kazumoto IIJIMA , Kandai NOZU , Akemi SHONO , Makoto KOIZUMI , Yoshiyuki ONISHI , Kiyosumi TAKAISHI , Tomomi ADACHI
IPC: C12N15/113 , A61K31/713 , A61P13/12
Abstract: The present invention aims at establishing a molecular therapy for Alport syndrome. The present invention provides an oligonucleotide of 15-30 bp comprising a nucleotide sequence complementary to the cDNA of COL4A5 gene, wherein the oligonucleotide is capable of inducing skipping of an exon which has a truncating mutation found in COL4A5 gene in Alport syndrome patients and whose nucleotide number is a multiple of 3, a pharmaceutically acceptable salt thereof, or a solvate thereof. Also provided is a pharmaceutical drug comprising the above oligonucleotide, a pharmaceutically acceptable salt thereof, or a solvate thereof (therapeutic drug for Alport syndrome).
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公开(公告)号：US10413236B2
公开(公告)日：2019-09-17
申请号：US14747199
申请日：2015-06-23
Inventor： Kota Aoyagi , Hitoshi Yamagata , Mizuho Nishio , Sumiaki Matsumoto
Abstract: A medical-image processing apparatus according to an embodiment includes an extracting unit, a dividing unit, and an estimating unit. The extracting unit extracts a disease candidate region from a medical image. The dividing unit divides the disease candidate region into multiple partial regions. The estimating unit uses the feature value of each of the partial regions to estimate the disease state of the disease candidate region.
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Patent Agency Ranking
公开(公告)号：US20190203198A1
公开(公告)日：2019-07-04
申请号：US15757243
申请日：2016-09-09
Inventor： Masaharu MUKOYAMA , Eita ICHIGE , Keiji NISHIDA , Akihiko KONDO
IPC: C12N15/10 , C12N1/20 , C12N9/22 , C07K14/245 , C12N9/78
Abstract: The invention provides a method of modifying a targeted site of gram-positive bacterium of a double stranded DNA. The method includes contacting the double-stranded DNA with a complex of a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a given double stranded DNA and a nucleic acid base converting enzyme to convert, delete, or insert one or more nucleotides in the targeted site without cleaving at least one strand of the double stranded DNA in the targeted site, by introducing the nucleic acid encoding the complex into the gram-positive bacterium. The invention also provide a nucleic acid-modifying enzyme complex of a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a double stranded DNA of a gram-positive bacterium and a nucleic acid base converting enzyme bonded to each other, which complex is used for the method.
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公开(公告)号：US20180284075A1
公开(公告)日：2018-10-04
申请号：US15885902
申请日：2018-02-01
Inventor： Noriyuki OJIMA , Shuichi KAWANA , Yumi UNNO , Takero SAKAI , Kenichi OBAYASHI , Yukihiko KUDO , Katsuyuki TANEDA , Masaru YOSHIDA , Shin NISHIUMI , Takashi KOBAYASHI , Takeshi AZUMA
Abstract: At least one stable isotope reagent is added to each biological sample and standard sample to prepare biological samples for analysis and standard sample for analysis. The quality of the biological samples is evaluated using data of one set of biological samples for analysis composed of a plurality of biological samples for analysis. Besides, the quality of a pretreatment and/or analysis of each set of samples for analysis is evaluated using data obtained by analyzing the standard sample for analysis before and after an analysis of one set of samples for analysis. An abnormality in a chromatograph or mass analyzer used for the analysis of one set of samples is evaluated by the data obtained by analyzing a sample for device evaluation before and after the analysis of one set of samples for analysis. Thus, the quality of data obtained by chromatographic mass spectrometry on biological samples is comprehensively evaluated.
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公开(公告)号：US10053435B2
公开(公告)日：2018-08-21
申请号：US15543547
申请日：2015-12-15
Inventor： Ryosuke Matsubara , Akihiro Ando , Masahiko Hayashi
IPC: C07D271/08
CPC classification number: C07D271/08 , A61K31/4245
Abstract: The present invention provides: a furoxan compound having a fluorine atom as a substituent group on the ring structure thereof; and a novel nitric oxide donor including the compound. The present invention relates to a fluorofuroxan compound represented by general formula (1) or (2). The compound of formula (1) can be manufactured by reacting a fluoride salt with a nitrofuroxan compound to substitute the nitro group with a fluoro group. The compound of formula (2) can be manufactured by subjecting the compounds of formula (1) to isomerization by irradiation with light.
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公开(公告)号：US20180004944A1
公开(公告)日：2018-01-04
申请号：US15543501
申请日：2016-01-12
Inventor： Makoto NAGATA , Jean-Luc DANGER , Daisuke FUJIMOTO , Shivam BHASIN
CPC classification number: G06F21/556 , G01R31/2884 , G01R31/31719 , G06F11/22 , H01L21/822 , H01L27/04 , H04L9/10
Abstract: Provided is an on-chip monitor circuit mounted on a semiconductor chip that is equipped with a security function module for performing a security function process on an input signal and outputting a security function signal, the on-chip monitor circuit comprising a monitor circuit for monitoring signal waveforms of the semiconductor chip, wherein the circuit is provided with a first storage means for storing data that designates a window period in which to perform a test of the semiconductor chip, and a control means for performing control to operate the circuit during the window period, when a prescribed test signal is inputted to the security function module. By using the on-chip monitor circuit in a semiconductor chip of which security is required, security attacks, e.g., a Trojan horse or the like, intended to embed a malicious circuit in the production stage of security function module-equipped semiconductors chips, can be prevented.
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公开(公告)号：US20170319485A1
公开(公告)日：2017-11-09
申请号：US15532951
申请日：2015-12-04
Inventor： Toshifumi Takeuchi , Yukiya Kitayama
IPC: A61K9/14 , A61K31/704 , A61K9/00 , C08F220/56 , A61K47/69
CPC classification number: A61K9/146 , A61K9/0019 , A61K31/704 , A61K47/6933 , A61P35/00 , B82Y5/00 , C08F2/44 , C08F220/56 , C08F220/54 , C08F230/02 , C08F222/385 , C08F220/34 , C08F220/36
Abstract: Provided is a molecular imprint polymer that is capable of acquiring stealth properties through a new mechanism. The molecular imprint polymer according to the present invention, which has a plasma protein recognition sites molecularly imprinted by a plasma protein thereon and contains a constituent derived from a biocompatible monomer, is an in vivo stealth nanoparticle to be used in intravascular delivery. As the plasma protein, albumin is preferred. When carrying a drug thereon, the in vivo stealth nanoparticle according to the present invention is usable as a drug for drug delivery system.
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