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公开(公告)号：US07816529B2
公开(公告)日：2010-10-19
申请号：US10884865
申请日：2004-07-02
申请人： Dean Mitchell Wilson , Esther Martinborough , Timothy Donald Neubert , Andreas Peter Termin , Jesus E. Gonzalez, III , Nicole Zimmerman
发明人： Dean Mitchell Wilson , Esther Martinborough , Timothy Donald Neubert , Andreas Peter Termin , Jesus E. Gonzalez, III , Nicole Zimmerman
IPC分类号： C07D239/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D401/06 , A61K31/506 , A61P19/02
CPC分类号： C07D239/42 , C07D239/48 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D413/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控离子通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US07767408B2
公开(公告)日：2010-08-03
申请号：US11444187
申请日：2006-05-31
IPC分类号： G01N33/53
CPC分类号： G01N33/542 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N33/5058 , G01N33/5061 , G01N33/5076 , G01N33/5088 , G01N33/6872
摘要： A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
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公开(公告)号：US07713983B2
公开(公告)日：2010-05-11
申请号：US10935008
申请日：2004-09-02
申请人： Jesus E. Gonzalez, III , Dean M. Wilson , Andreas P. Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin J. Petzoldt , Lev Tyler Dewey Fanning , Timothy D. Neubert , Roger D. Tung , Esther Martinborough , Nicole Zimmerman
发明人： Jesus E. Gonzalez, III , Dean M. Wilson , Andreas P. Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin J. Petzoldt , Lev Tyler Dewey Fanning , Timothy D. Neubert , Roger D. Tung , Esther Martinborough , Nicole Zimmerman
IPC分类号： C07D239/94 , C07D403/12 , A61K31/517 , A61P35/00
CPC分类号： C07D239/91 , C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道和钙通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20100081163A1
公开(公告)日：2010-04-01
申请号：US12568604
申请日：2009-09-28
IPC分类号： C12Q1/02
CPC分类号： G01N33/5038 , G01N33/48728 , G01N33/5008 , G01N33/5076 , G01N33/5088 , G01N33/542 , G01N33/6872
摘要： A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
摘要翻译： 表征候选化合物的生物活性的方法可以包括将细胞暴露于候选化合物，然后将细胞暴露于电场的重复施用，以将跨膜电位设定为与预选电压相关的水平 目标离子通道的状态。
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公开(公告)号：US07615563B2
公开(公告)日：2009-11-10
申请号：US11060719
申请日：2005-02-17
IPC分类号： C07D277/46 , C07D417/12 , A61K31/426 , A61K31/4709 , A61K31/4725
CPC分类号： C04B35/632 , C07C311/46 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D239/52 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US07615356B2
公开(公告)日：2009-11-10
申请号：US10620312
申请日：2003-07-14
IPC分类号： G01N33/53
CPC分类号： G01N33/5038 , G01N33/48728 , G01N33/5008 , G01N33/5076 , G01N33/5088 , G01N33/542 , G01N33/6872
摘要： A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
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公开(公告)号：US20090253159A1
公开(公告)日：2009-10-08
申请号：US11443577
申请日：2006-05-30
IPC分类号： C12Q1/02
CPC分类号： G01N33/542 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N33/5058 , G01N33/5061 , G01N33/5076 , G01N33/5088 , G01N33/6872
摘要： A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
摘要翻译： 表征候选化合物的生物活性的方法可以包括将细胞暴露于候选化合物，然后将细胞暴露于电场的重复施用，以将跨膜电位设定为与预选电压相关的水平 目标离子通道的状态。
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公开(公告)号：US07399599B2
公开(公告)日：2008-07-15
申请号：US09804457
申请日：2001-03-12
IPC分类号： G01N33/53
CPC分类号： G01N33/542 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N33/5058 , G01N33/5061 , G01N33/5076 , G01N33/5088 , G01N33/6872
摘要： A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
摘要翻译： 表征候选化合物的生物活性的方法可以包括将细胞暴露于候选化合物，然后将细胞暴露于电场的重复施用，以将跨膜电位设定为与预选电压相关的水平 目标离子通道的状态。
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公开(公告)号：US07312043B2
公开(公告)日：2007-12-25
申请号：US09804480
申请日：2001-03-12
IPC分类号： G01N33/53
CPC分类号： G01N33/542 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N33/5058 , G01N33/5061 , G01N33/5076 , G01N33/5088 , G01N33/6872
摘要： A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
摘要翻译： 表征候选化合物的生物活性的方法可以包括将细胞暴露于候选化合物，然后将细胞暴露于电场的重复施用，以将跨膜电位设定为与预选电压相关的水平 目标离子通道的状态。
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公开(公告)号：US07309716B2
公开(公告)日：2007-12-18
申请号：US10977609
申请日：2004-10-28
申请人： Dean M. Wilson , Andreas P. Termin , Jesus E. Gonzalez, III , Nicole Zimmermann , Yulian Zhang , Lev T. D. Fanning
发明人： Dean M. Wilson , Andreas P. Termin , Jesus E. Gonzalez, III , Nicole Zimmermann , Yulian Zhang , Lev T. D. Fanning
IPC分类号： A61K31/4184 , C07D235/06
CPC分类号： C07D405/12 , C04B35/632 , C07D209/42 , C07D235/14 , C07D235/18 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R1, Z, Y, RA, and W groups of formula I are as defined herein. The invention also provides pharmaceutically acceptable compositions and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，其中R 1，Z，Y，R A和W分别为 如本文所定义。 本发明还提供药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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