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公开(公告)号：US08202861B2
公开(公告)日：2012-06-19
申请号：US10914988
申请日：2004-08-09
IPC分类号： A61K31/5415 , A61K31/5377 , A61K31/522 , A61K31/513 , A61K31/517
CPC分类号： C07D417/14 , C04B35/632 , C07C311/46 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D239/52 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：US20090253682A1
公开(公告)日：2009-10-08
申请号：US12424883
申请日：2009-04-16
IPC分类号： A61K31/55 , C07D405/12 , C07D401/12 , C07D403/14 , C07D403/12 , A61K31/4525 , A61K31/454 , C07D491/113
CPC分类号： A61K31/405 , A61K31/343 , A61K31/381 , A61K31/404 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55
摘要： Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
摘要翻译： 杂环衍生物作为Ca通道拮抗剂。 该组合物可用于治疗或缓解Ca通道介导的病症。
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公开(公告)号：US20080293737A1
公开(公告)日：2008-11-27
申请号：US12124303
申请日：2008-05-21
申请人： Esther Martinborough , Tim Neubert , Tara Whitney , Danielle Lehsten , Tara Hampton , Nicole Zimmerman , Andreas P. Termin
发明人： Esther Martinborough , Tim Neubert , Tara Whitney , Danielle Lehsten , Tara Hampton , Nicole Zimmerman , Andreas P. Termin
IPC分类号： A61K31/496 , C07D401/06 , A61K31/404 , A61P25/00 , C07D209/04
CPC分类号： C07D209/08 , C07C311/51 , C07C311/53 , C07C2602/08 , C07D209/42 , C07D215/06 , C07D215/233 , C07D317/60 , C07D401/04 , C07D401/06 , C07D405/12
摘要： In general, the invention relates to compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels.
摘要翻译： 通常，本发明涉及可用作离子通道调节剂的化合物。 现在已经发现，本发明的化合物及其药学上可接受的组合物可用作电压门控钠通道的抑制剂。
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公开(公告)号：US20060074076A1
公开(公告)日：2006-04-06
申请号：US11165254
申请日：2005-06-22
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/405 , A61K31/381 , A61K31/343
CPC分类号： A61K31/405 , A61K31/343 , A61K31/381 , A61K31/404 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55
摘要： Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
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公开(公告)号：US20050187217A1
公开(公告)日：2005-08-25
申请号：US10912912
申请日：2004-08-05
申请人： Dean Wilson , Andreas Termin , Timothy Neubert , Jian Wang , Yulian Zhang , Jesus Gonzalez , Esther Martinborough , Nicole Zimmerman
发明人： Dean Wilson , Andreas Termin , Timothy Neubert , Jian Wang , Yulian Zhang , Jesus Gonzalez , Esther Martinborough , Nicole Zimmerman
IPC分类号： A61K31/517 , A61K31/5377 , A61P25/00 , A61P29/00 , C07D239/70 , C07D239/91 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/12 , C07D413/02 , C07D471/04 , C07D495/04 , C07D43/02
CPC分类号： C07D401/04 , C07D239/70 , C07D239/91 , C07D239/94 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D471/04 , C07D495/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US07678802B2
公开(公告)日：2010-03-16
申请号：US10792688
申请日：2004-03-03
申请人： Jesus E. Gonzalez, III , Dean Mitchell Wilson , Andreas Peter Termin , Peter Diederik Jan Grootenhuis , Yulian Zhang , Benjamin John Petzoldt , Lev Tyler Dewey Fanning , Timothy Donald Neubert , Roger Tung , Esther Martinborough , Nicole Zimmerman
发明人： Jesus E. Gonzalez, III , Dean Mitchell Wilson , Andreas Peter Termin , Peter Diederik Jan Grootenhuis , Yulian Zhang , Benjamin John Petzoldt , Lev Tyler Dewey Fanning , Timothy Donald Neubert , Roger Tung , Esther Martinborough , Nicole Zimmerman
IPC分类号： C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , A61K31/517 , C07D417/04 , C07D417/12 , C07D417/14 , C07D409/04 , C07D405/12 , C07D413/12 , A61K31/5377 , A61P35/00
CPC分类号： C07D239/94 , C07D239/91 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：US07569604B2
公开(公告)日：2009-08-04
申请号：US11165254
申请日：2005-06-22
IPC分类号： A61K31/343 , A61K31/443 , A61K31/4525 , A61K31/4545 , A61K31/495 , A61K31/5377 , C07D405/12 , C07D405/14 , C07D407/14
CPC分类号： A61K31/405 , A61K31/343 , A61K31/381 , A61K31/404 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55
摘要： Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
摘要翻译： 杂环衍生物作为Ca通道拮抗剂。 该组合物可用于治疗或缓解Ca通道介导的病症。
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公开(公告)号：US20060217377A1
公开(公告)日：2006-09-28
申请号：US10935008
申请日：2004-09-02
申请人： Jesus Gonzalez , Dean Wilson , Andreas Termin , Peter Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Zimmerman
发明人： Jesus Gonzalez , Dean Wilson , Andreas Termin , Peter Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Zimmerman
IPC分类号： A61K31/5377 , A61K31/517 , C07D413/02 , C07D43/02
CPC分类号： C07D239/91 , C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道和钙通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20120238578A1
公开(公告)日：2012-09-20
申请号：US13478538
申请日：2012-05-23
IPC分类号： A61K31/427 , A61K31/428 , A61K31/4245 , A61K31/517 , A61K31/53 , A61K31/498 , A61K31/4725 , A61P25/00 , A61P19/02 , A61P25/06 , A61P25/08 , A61P25/28 , A61P25/18 , A61P25/22 , A61P25/24 , A61P9/06 , A61P25/14 , A61P1/00 , C12N5/071 , A61K31/4709
CPC分类号： C07D417/14 , C04B35/632 , C07C311/46 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D239/52 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20120040935A1
公开(公告)日：2012-02-16
申请号：US13110173
申请日：2011-05-18
申请人： Dean M. Wilson , Andreas P. Termin , Timothy D. Neubert , Jian Wang , Yulian Zhang , Jesus E. Gonzalez, III , Esther Martinborough , Nicole Zimmerman
发明人： Dean M. Wilson , Andreas P. Termin , Timothy D. Neubert , Jian Wang , Yulian Zhang , Jesus E. Gonzalez, III , Esther Martinborough , Nicole Zimmerman
IPC分类号： A61K31/675 , A61K31/517 , C12N5/071 , A61P29/00 , A61P25/04 , A61P19/02 , A61P25/06 , A61P25/00 , A61P25/22 , A61P25/24 , A61P9/06 , A61P25/14 , A61P25/28 , A61P1/00 , A61P21/00 , A61K31/5377
CPC分类号： C07D401/04 , C07D239/70 , C07D239/91 , C07D239/94 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D471/04 , C07D495/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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