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141 条记录 (耗时 0.028 秒)

    Methods and materials relating to novel CD39-like polypeptides
    21.
    发明授权
    Methods and materials relating to novel CD39-like polypeptides 失效
    与新型CD39样多肽相关的方法和材料

    公开(公告)号：US06447771B1

    公开(公告)日：2002-09-10

    申请号：US09370265

    申请日：1999-08-09

    申请人： John Ford ,  Julio J. Mulero ,  George Yeung

    发明人： John Ford ,  Julio J. Mulero ,  George Yeung

    IPC分类号： A61K3847

    CPC分类号： C07K14/70596 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  C12N9/14 ,  C12Q1/6883

    摘要： The invention provides polynucleotides isolated from cDNA libraries of human fetal liver-spleen and macrophage as well as polypeptides encoded by these polynucleotides and mutants or variants thereof. The polypeptides correspond to a human CD39-like protein. Other aspects of the invention include vectors containing polynucleotides of the invention and related host cells as well a processes for producing CD39-like polypeptides, and antibodies specific for such polypeptides.

    摘要翻译： 本发明提供从人胎儿肝脾和巨噬细胞的cDNA文库中分离的多核苷酸，以及由这些多核苷酸及其突变体或变体编码的多肽。 多肽对应于人CD39样蛋白。 本发明的其它方面包括含有本发明多核苷酸和相关宿主细胞的载体以及产生CD39样多肽的方法，以及对这些多肽具有特异性的抗体。

    Anti-interleukin-1 receptor antagonist antibodies and uses thereof
    22.
    发明授权
    Anti-interleukin-1 receptor antagonist antibodies and uses thereof 失效
    抗白细胞介素-1受体拮抗剂抗体及其用途

    公开(公告)号：US06294655B1

    公开(公告)日：2001-09-25

    申请号：US09417455

    申请日：1999-10-13

    申请人： John Ford ,  Ann Pace

    发明人： John Ford ,  Ann Pace

    IPC分类号： C07K1618

    CPC分类号： C07K14/545 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention provides novel nucleic acids, the novel polypeptide sequences encoded by these nucleic acids and uses thereof. These novel polynucleotide and polypeptide sequences were determined to be a novel Interleukin-1 Receptor Antagonist. Also provided are antibodies which bind the antagonist, methods of detecting the antagonist, and kits containing the antibodies.

    摘要翻译： 本发明提供了新的核酸，由这些核酸编码的新的多肽序列及其用途。 这些新的多核苷酸和多肽序列被确定为新的白细胞介素-1受体拮抗剂。 还提供了结合拮抗剂的抗体，检测拮抗剂的方法和含有抗体的试剂盒。

    Loading and unloading apparatus
    23.
    发明授权
    Loading and unloading apparatus 失效
    装卸装置

    公开(公告)号：US5186596A

    公开(公告)日：1993-02-16

    申请号：US770836

    申请日：1991-10-04

    申请人： Paul Boucher ,  Mario Boucher ,  John Ford ,  Gregg Stephenson

    发明人： Paul Boucher ,  Mario Boucher ,  John Ford ,  Gregg Stephenson

    IPC分类号： B65G67/20

    CPC分类号： B65G67/20

    摘要： A longitudinal extensible platform comprises a plurality of framed sections hingedly joined together. Each framed section comprises a first set of ground engaging rollers and a second set of load engaging rollers extending transversely of the framed section. A drive is mounted below the surface of the loading dock for driving an endless chain. The extensible platform is drivingly engaged to the endless chain and adapted for longitudinal movement therealong. The extensible platform has a platen at a forward end hingedly engaging the first framed section. The extensible platform is provided with a driven pusher assembly mounted thereon. The pusher assembly extending upwardly for abutting with the load resting on the extensible platform.

    摘要翻译： 纵向可伸展平台包括铰接在一起的多个框架部分。 每个框架部分包括第一组地面接合辊和横向于框架部分延伸的第二组负载接合辊。 驱动器安装在装载底座的表面下方，用于驱动环形链条。 可伸缩平台被驱动地接合到环形链条上，适用于纵向运动。 可伸展平台在前端具有与第一框架部分铰接接合的压板。 可伸展平台设置有安装在其上的从动推动器组件。 推动器组件向上延伸以与搁置在可延伸平台上的负载邻接。

    Thieno[3,2-c]pyridine potassium channel inhibitors
    27.
    发明授权
    Thieno[3,2-c]pyridine potassium channel inhibitors 有权
    噻吩并[3,2-c]吡啶钾通道抑制剂

    公开(公告)号：US09216992B2

    公开(公告)日：2015-12-22

    申请号：US11635786

    申请日：2006-12-08

    申请人： John Ford ,  David John Madge ,  Helen Jane Payne ,  Jamie David Knight

    发明人： John Ford ,  David John Madge ,  Helen Jane Payne ,  Jamie David Knight

    IPC分类号： C07D495/04 ,  A61K31/4365

    CPC分类号： C07D495/04

    摘要： The present invention provides thienopyridine compounds which are potassium channel inhibitors. In another embodiment, the invention provides pharmaceutical compositions comprising thienopyridines. In another embodiment, the invention provides methods of using thienopyridines in the treatment or prevention of cancer, arrhythmias, autoimmune diseases and inflammatory diseases, including gastric cancer, atrial fibrillation, type-2 diabetes mellitus, rheumatoid arthritis, type-1 diabetes, inflammatory bowel disorder and demyelinating disorders such as multiple sclerosis.

    摘要翻译： 本发明提供作为钾通道抑制剂的噻吩并吡啶化合物。 在另一个实施方案中，本发明提供了包含噻吩并吡啶的药物组合物。 在另一个实施方案中，本发明提供了使用噻吩并吡啶治疗或预防癌症，心律失常，自身免疫性疾病和炎性疾病的方法，包括胃癌，心房颤动，2型糖尿病，类风湿性关节炎，1型糖尿病，炎性肠 紊乱和脱髓鞘疾病如多发性硬化。

    SYSTEM AND METHOD FOR AN AUTOMATED CONCIERGE
    28.
    发明申请
    SYSTEM AND METHOD FOR AN AUTOMATED CONCIERGE 审中-公开
    自动化系统与方法

    公开(公告)号：US20140114706A1

    公开(公告)日：2014-04-24

    申请号：US14144481

    申请日：2013-12-30

    申请人： John Ford Blakely

    发明人： John Ford Blakely

    IPC分类号： G06Q10/02

    CPC分类号： G06Q10/02 ,  G06Q10/10 ,  G06Q50/12

    摘要： A concierge system that coordinates incoming message requests between a wireless device and a merchant computer system having various service departments to fulfill a requested action. The concierge server receives incoming message requests for service from the wireless device. A concierge application is resident on the concierge server, and the concierge application is configured to receive an incoming message from the wireless device for a requested service. In response to the incoming message, a reply message is sent back acknowledging receipt of the incoming message to the wireless device. Simultaneously, the merchant computer system is notified of the incoming message request.

    摘要翻译： 一种礼宾系统，其协调无线设备和具有各种服务部门的商务计算机系统之间的传入消息请求，以实现所请求的动作。 礼宾服务器从无线设备接收来自服务的传入消息请求。 礼宾服务应用程序驻留在礼宾服务器上，礼宾服务应用程序被配置为从无线设备接收所请求的服务的传入消息。 响应于传入消息，回复消息被确认接收到无线设备的传入消息。 同时，向商家计算机系统通知传入的消息请求。

    Self-heating systems and methods for rapidly heating a comestible substance
    29.
    发明授权
    Self-heating systems and methods for rapidly heating a comestible substance 有权
    用于快速加热食用物质的自加热系统和方法

    公开(公告)号：US08578926B2

    公开(公告)日：2013-11-12

    申请号：US12719774

    申请日：2010-03-08

    申请人： John Ford ,  Douglas Lund

    发明人： John Ford ,  Douglas Lund

    IPC分类号： F24J1/00

    CPC分类号： B65B3/04 ,  A23L5/10 ,  A47J36/28 ,  B65B7/2835 ,  B65D51/20 ,  B65D81/3484 ,  B65D2543/00046 ,  F24V30/00

    摘要： Self-heating containers comprise a reaction chamber and a heating chamber. The heating chamber is sized to contain a substance to be heated. The reaction chamber contains reactants which, when contacted, exothermically react. The reaction chamber is divided into a first compartment and a second compartment with a barrier therebetween. The barrier comprises a first barrier portion and a second barrier portion. The first barrier portion is attached to a reaction chamber wall and has an opening sized to allow reactants to flow through from one compartment to the other. The second barrier portion is attached to the first barrier portion to close the opening. The barrier can be opened by moving an actuator into engagement with the second barrier portion to dislodge the second barrier portion from the first barrier portion and thereby open the barrier. In certain embodiments, the heating chamber can be a can with prepackaged comestible substance therein. Examples of components configured to facilitate such a can are disclosed.

    摘要翻译： 自加热容器包括反应室和加热室。 加热室的大小适于容纳待加热物质。 反应室含有当接触时放热反应的反应物。 反应室被分成第一隔室和第二隔室，隔室之间具有阻挡层。 阻挡层包括第一阻挡部分和第二阻挡部分。 第一阻挡部分连接到反应室壁上，并且具有一定尺寸以允许反应物从一个隔室流过另一隔室的开口。 第二阻挡部分附接到第一阻挡部分以封闭开口。 可以通过将致动器移动到与第二阻挡部分接合以将第二阻挡部分从第一阻挡部分移开并从而打开阻挡物来打开阻挡物。 在某些实施方案中，加热室可以是其中预包装的可食物质的罐。 公开了配置成便于这种罐的部件的例子。

    Online method and system for advising customers on service needs, facilitating the scheduling of vehicle service appointments, and checking vehicle service status
    30.
    发明授权
    Online method and system for advising customers on service needs, facilitating the scheduling of vehicle service appointments, and checking vehicle service status 有权
    在线方法和系统，为客户提供有关服务需求的咨询，促进车辆服务预约的安排和检查车辆服务状况

    公开(公告)号：US08521654B2

    公开(公告)日：2013-08-27

    申请号：US10442806

    申请日：2003-05-21

    申请人： David John Ford ,  John Garfield Graham ,  Joseph Retzbach ,  Kenneth James McCaffrey ,  Nadine Ann Mooney

    发明人： David John Ford ,  John Garfield Graham ,  Joseph Retzbach ,  Kenneth James McCaffrey ,  Nadine Ann Mooney

    IPC分类号： G06Q10/00

    CPC分类号： G06Q10/10 ,  G06Q10/20

    摘要： One aspect of the present invention is an online method for advising a customer on service needs and facilitating the scheduling of a vehicle service appointment. The method can comprise receiving a service inquiry, receiving input information regarding potential service of the vehicle, transmitting an open appointments request to a dealer management system (DMS), receiving a plurality of open appointments from the DMS, causing display of the plurality of open appointments wherein one of the plurality of open appointments is selected as an appointment request, and transmitting the input information and the appointment request to the DMS to facilitate the scheduling of the vehicle service appointment. The last four steps outlined can be conducted in substantially real-time.

    摘要翻译： 本发明的一个方面是一种在线方法，用于向客户咨询服务需求并促进车辆服务预约的调度。 该方法可以包括接收服务询问，接收关于车辆的潜在服务的输入信息，向经销商管理系统（DMS）发送开放约会请求，从DMS接收多个开放约会，导致显示多个开放 其中，所述多个开放约会中的一个被选择为约会请求，并且将所述输入信息和所述约会请求发送到所述DMS以便于所述车辆服务预约的调度。 概述的最后四个步骤可以基本上实时进行。