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    Biopatch, bioheater, biosensor and bioelectronic patch device
    26.
    发明授权
    Biopatch, bioheater, biosensor and bioelectronic patch device 有权

    公开(公告)号：US10993910B2

    公开(公告)日：2021-05-04

    申请号：US16467943

    申请日：2016-12-07

    Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  INSTITUTE FOR BASIC SCIENCE

    Inventor： Daehyeong Kim ,  Seunghong Choi ,  Taeghwan Hyeon ,  Jongha Lee ,  Hyerim Cho ,  Hyunseon Seo

    IPC: A61K9/00 ,  A61K9/70 ,  A61K47/02 ,  A61K47/34 ,  A61K47/36

    Abstract: A biopatch, a bioheater, a biosensor and a bioelectronic patch device are provided.
    The biopatch comprises a polymer film comprising a biopolymer and a drug loaded in the polymer film. The biopolymer may comprise one or more than one of a bioabsorbable polymer, a biodegradable polymer and a biocompatible polymer. The biopolymer may comprise oxidized starch. The drug may comprise a first drug chemically combined with the oxidized starch and a second drug physically combined with the oxidized starch.
    The bioheater comprises a heater comprising biometal. The biometal may comprise Mg or Fe. The heater can be controlled wirelessly by an alternating magnetic field.
    A biosensor according to one embodiment of the present inventive concept comprises an inductor and a capacitor connected to the inductor, wherein the capacitor comprises a first electrode, a second electrode facing the first electrode and a dielectric disposed between the first electrode and the second electrode, each of the inductor, the first electrode and the second electrode comprises biometal, and the dielectric comprises a biopolymer having a glass transition temperature in a range of 36˜42° C. A biosensor according to another embodiment of the present inventive concept comprises an inductor and a capacitor connected to the inductor, wherein the capacitor comprises a first electrode, a second electrode facing the first electrode and a dielectric disposed between the first electrode and the second electrode, a change in a dielectric constant of the dielectric is transmitted to an external device through a resonance frequency change with the inductor, and the external device measures temperature around the biosensor by measuring the resonance frequency change wirelessly.
    A bioelectronic patch device according to one embodiment of the present inventive concept comprises a drug patch comprising a polymer film comprising a biopolymer and a drug loaded in the polymer film, and a heater adjacent to the drug patch to heat the drug patch. A bioelectronic patch device according to another embodiment of the present inventive concept comprises a drug patch comprising a polymer film comprising a biopolymer and a drug loaded in the polymer film, a first protection layer disposed on the drug patch, a heater disposed on the first protection layer and heating the drug patch, a temperature sensor disposed on the first protection layer, spaced apart from the heater and measuring temperature of the heater, and a second protection layer covering the heater and the temperature sensor on the first protection layer.

    NOVEL BIFIDOBACTERIUM BIFIDUM STRAIN AND STRAIN-DERIVED POLYSACCHARIDE
    27.
    发明申请
    NOVEL BIFIDOBACTERIUM BIFIDUM STRAIN AND STRAIN-DERIVED POLYSACCHARIDE 有权

    公开(公告)号：US20210077521A1

    公开(公告)日：2021-03-18

    申请号：US16621442

    申请日：2018-06-14

    Applicant: INSTITUTE FOR BASIC SCIENCE ,  POSTECH ACADEMY-INDUSTRY FOUNDATION

    Inventor： Sin-Hyeog IM ,  Ravi VERMA ,  Changhon LEE

    IPC: A61K31/716 ,  C12N5/0783 ,  A61K35/745

    Abstract: The present invention relates to a Bifidobacterium bifidum inducing regulatory T cells (Treg), a polysaccharide derived from Bifidobacterium bifidum, and a probiotic strain producing a polysaccharide and, more particularly, a polysaccharide containing β-1-6-glucan as an effective ingredient, a probiotic strain producing β-1-6-glucan, a food comprising the polysaccharide or strain as an effective ingredient for alleviation of immune disease or inflammatory disease, a therapeutic agent comprising the polysaccharide or strain as an effective ingredient for alleviation of immune disease or inflammatory disease, a method for preparing induced regulatory T cells (iTreg) by treatment with the polysaccharide or strain, and a cell therapy product for prevention or treatment of immune disease or inflammatory disease, comprising the induced regulatory T cells prepared by the method.

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