公开(公告)号：US20210378904A1

公开(公告)日：2021-12-09

申请号：US17343628

申请日：2021-06-09

Applicant: Arizona Board of Regents on Behalf of Northern Arizona University

Inventor： Zachary F. Lerner ,  Grigoriy Orekhov

IPC: A61H3/00 ,  A61H1/02

Abstract: A low-weight, high performance wearable assistive device for assisting motion of a joint of a wearer (e.g., an ankle) and/or resistance training of motion of the joint includes a lightweight upright member that may be attached to the wearer (e.g., fastened to the wearer's outside calf). Forces to assist or resist movement of the joint are coupled to a rotation bearing via cables. The bearing is disposed within the upright member such torsional deflection of the device under load is reduced, allowing the upright member to be lighter and/or less obtrusive to the wearer and less susceptible to failure.

公开(公告)号：US20210339381A1

公开(公告)日：2021-11-04

申请号：US17374875

申请日：2021-07-13

Applicant: Arizona Board of Regents on Behalf of Northern Arizona University

Inventor： Zachary F Lerner

IPC: B25J9/00 ,  A61H3/00 ,  A61B5/00 ,  A61B5/103

Abstract: An exoskeleton device is provided herein that includes a control unit including a controller. At least one embedded sensor is configured to acquire data. An actuator is in electrical communication with the at least one embedded sensor and the controller. The controller is configured to adjust a level of assistance or resistance provided by the actuator in response to a change in a performance metric as measured by the acquired data.

公开(公告)号：US11098349B2

公开(公告)日：2021-08-24

申请号：US15773270

申请日：2016-11-03

Applicant: The Translational Genomics Research Institute ,  Arizona Board of Regents on Behalf of Northern Arizona University

Inventor： Elizabeth Driebe ,  Jolene Bowers ,  David Engelthaler ,  Paul Keim

IPC: C12Q1/686 ,  C12Q1/689

Abstract: Embodiments of the invention include methods of identifying microorganisms and/or diagnosing infections in subjects cause by microorganisms. Embodiments of the invention may also include further characterizing (e.g., determining the presence of one or more antibiotic resistance markers) the microorganisms and determining a strain identity of the microorganisms.

公开(公告)号：US11034016B2

公开(公告)日：2021-06-15

申请号：US16409670

申请日：2019-05-10

Applicant: Arizona Board of Regents on Behalf of Northern Arizona University

Inventor： Zachary F Lerner

IPC: A61H3/00 ,  B25J9/00 ,  A61B5/00 ,  A61B5/103 ,  A61H1/02

Abstract: A method of using an ankle exoskeleton device is provided herein. The method includes collecting one or more biomechanical data points from an individual. The method also includes developing individualized musculoskeletal simulations based on the one or more biomechanical data points. In addition, the method includes creating predictive simulations by modeling effects of an ankle exoskeleton device on the individualized musculoskeletal simulations. The method also includes utilizing established device-user relationships with real-time measurements to adjust device control. Lastly, the method includes optimizing design and control parameters of the exoskeleton device based on the predictive simulations and user responses.

公开(公告)号：US20210152347A1

公开(公告)日：2021-05-20

申请号：US16951760

申请日：2020-11-18

Applicant: Arizona Board of Regents on Behalf of Northern Arizona University

Inventor： Bertrand F CAMBOU ,  Ines MONTANO ,  Ryan BEHUNIN ,  Vince RODRIGUEZ

IPC: H04L9/08 ,  H04B10/079 ,  H04B10/70

Abstract: The performance of quantum key distribution by systems and methods that use wavelength division multiplexing and encode information using both wavelength and polarization of photons of two or more wavelengths. Multi-wavelength polarization state encoding schemes allow ternary-coded digits, quaternary-coded digits and higher-radix digits to be represented by single photons. Information expressed in a first radix can be encoded in a higher radix and combined with a string of key values to produce a datastream having all allowed digit values of that radix in a manner that allows eavesdropping to be detected without requiring the sender and receiver to exchange additional information after transmission of the information.

公开(公告)号：US10722550B2

公开(公告)日：2020-07-28

申请号：US16250612

申请日：2019-01-17

Applicant: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE ,  ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY

Inventor： David Engelthaler ,  Elizabeth Driebe ,  Hongwei “Holly” Yin ,  Michael Valentine ,  Donald Chow ,  Jolene Bowers ,  Paul Keim ,  Bridget Barker

IPC: A61K31/41 ,  A61K31/135 ,  A61K38/13 ,  A61K31/7135 ,  A61K31/58 ,  A61K31/5377 ,  A61K31/5415 ,  A61K31/4196 ,  A61K31/496 ,  A61K31/495 ,  A61K45/06 ,  A61K31/138 ,  A61K31/277 ,  A61K31/353 ,  A61K31/404 ,  A61K31/4174 ,  A61K31/428 ,  A61K31/4741 ,  A61K31/609

Abstract: The present invention comprises methods of treating an infection using a pharmaceutical composition comprising an active ingredient selected from Table 1. In some aspects, the infection can be caused by one or more pathogens, including fungal pathogens. For example, the infection may be Valley Fever.

公开(公告)号：US20200150929A1

公开(公告)日：2020-05-14

申请号：US16492581

申请日：2018-07-27

Applicant: Arizona Board of Regents on Behalf of Northern Arizona University

Inventor： Bertrand Francis Cambou

IPC: G06F7/58 ,  H04L9/32 ,  G06F7/49

Abstract: A system and method for random number generation are presented. A plurality of parameter values are generated by inspecting a plurality of cells in a memory array. Each parameter value in the plurality of parameter values is associated with a cell of the plurality of cells. A plurality of unstable cells in the plurality of cells are identified. Each unstable cell in the plurality of unstable cells is associated with a parameter value within a threshold value of an average of the plurality of parameter values. First, second and third groups of cells in the plurality of unstable cells identified and associated with values. The groups are determined based upon the parameter values associated with the cells in each group. A data stream is generated using the first group of cells, the second group of cells, and the third group of cells.

公开(公告)号：US20200063193A1

公开(公告)日：2020-02-27

申请号：US16677646

申请日：2019-11-07

Applicant: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE ,  ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Rebecca E. Colman ,  David M. Engelthaler ,  James M. Schupp ,  Paul Keim ,  David Smith ,  Antonino Catanzaro ,  Timothy Rodwell

IPC: C12Q1/689 ,  G16B30/00 ,  C12Q1/6858

Abstract: The present invention provides a method of detecting a heteroresistant population of a pathogen in a sample, the method comprising: a) providing a sample comprising a population of a pathogen; b) extracting nucleic acids from the sample; c) amplifying a target locus of the genome of the pathogen in the extracted nucleic acids, wherein the target locus comprises at least one minor variant associated with drug resistance in the pathogen; d) consecutively sequencing both overlapping nucleic acid strands from a single DNA molecule amplified from the target locus on a Next Generation Sequencing (NGS) platform; e) applying an alignment algorithm to sequencing data from the overlapping nucleic acid strands; and f) performing an analysis of the aligned sequencing data to detect the at least one minor variant and heteroresistant population of the pathogen.

公开(公告)号：US10508311B2

公开(公告)日：2019-12-17

申请号：US14912918

申请日：2014-08-26

Applicant: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE ,  ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Rebecca E. Colman ,  David M. Engelthaler ,  James M. Schupp ,  Paul Keim ,  David Smith ,  Antonino Catanzaro ,  Timothy Rodwell

IPC: G01N33/48 ,  C12Q1/689 ,  G16B30/00 ,  C12Q1/6858

Abstract: The present invention provides a method of detecting a heteroresistant population of a pathogen in a sample, the method comprising: a) providing a sample comprising a population of a pathogen; b) extracting nucleic acids from the sample; c) amplifying a target locus of the genome of the pathogen in the extracted nucleic acids, wherein the target locus comprises at least one minor variant associated with drug resistance in the pathogen; d) consecutively sequencing both overlapping nucleic acid strands from a single DNA molecule amplified from the target locus on a Next Generation Sequencing (NGS) platform; e) applying an alignment algorithm to sequencing data from the overlapping nucleic acid strands; and f) performing an analysis of the aligned sequencing data to detect the at least one minor variant and heteroresistant population of the pathogen.

公开(公告)号：US20190352702A1

公开(公告)日：2019-11-21

申请号：US16283232

申请日：2019-02-22

Applicant: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE ,  ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY

Inventor： Jolene Bowers ,  Elizabeth Driebe ,  David Engelthaler ,  Paul Keim

IPC: C12Q1/689

Abstract: Embodiments of the invention provide a method of detecting one or more strains of Klebsiella pneumoniae. The method may include forming a plurality of mixtures for nucleic amplification. The method can include amplification of specific sequences within the K. pneumonia genome that can provide definitive information to distinguish between one or more types or strains of K. pneumonia.