公开(公告)号：US20110160120A1

公开(公告)日：2011-06-30

申请号：US13010267

申请日：2011-01-20

申请人： Kunwar Shailubhai ,  Gary S. Jacob

发明人： Kunwar Shailubhai ,  Gary S. Jacob

IPC分类号： A61K38/16 ,  C07K7/08 ,  C07K14/00 ,  A61K38/10 ,  C12N5/071 ,  A61P29/00 ,  A61P35/00 ,  A61P9/04 ,  A61P1/04 ,  A61P1/00 ,  A61P9/12 ,  A61P11/06 ,  A61P11/00 ,  A61P1/10

CPC分类号： C07K7/08 ,  A61K9/0031 ,  A61K9/02 ,  A61K9/08 ,  A61K31/192 ,  A61K31/519 ,  A61K38/10 ,  A61K38/12 ,  A61K45/06 ,  A61K47/02 ,  A61K47/60 ,  C07K7/64

摘要： The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. The gastrointestinal disease may be classified as either inflammatory bowel disease or other GI condition, including Crohn's disease and ulcerative colitis, and cancer.

摘要翻译： 本发明提供新的鸟苷酸环化酶-C激动剂肽及其在治疗包括胃肠道疾病，炎症或癌症（例如胃肠癌））的人类疾病中的用途。 肽可以单独施用或与cGMP依赖性磷酸二酯酶抑制剂组合施用。 胃肠道疾病可以分为肠易激综合征，便秘或过度酸度等。胃肠道疾病可分为炎症性肠病或其他GI病症，包括克罗恩病和溃疡性结肠炎，以及癌症。

公开(公告)号：US20100069306A1

公开(公告)日：2010-03-18

申请号：US12478505

申请日：2009-06-04

申请人： Kunwar Shailubhai ,  Gary S. Jacob

发明人： Kunwar Shailubhai ,  Gary S. Jacob

IPC分类号： A61K38/10 ,  C07K7/08 ,  C12N5/02

CPC分类号： C07K7/64 ,  A61K38/04 ,  A61K45/06 ,  C07K7/08 ,  A61K2300/00

摘要： The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. The gastrointestinal disease may be classified as either inflammatory bowel disease or other GI condition including Crohn's disease and ulcerative colitis, and cancer.

公开(公告)号：US20090048175A1

公开(公告)日：2009-02-19

申请号：US12133344

申请日：2008-06-04

申请人： Kunwar Shailubhai ,  Gary S. Jacob

发明人： Kunwar Shailubhai ,  Gary S. Jacob

IPC分类号： A61K38/10 ,  C07K7/08 ,  A61K38/16 ,  A61P35/00 ,  A61P11/00 ,  A61P1/00 ,  A61P29/00 ,  C07K14/00

CPC分类号： C07K7/08 ,  A61K9/0031 ,  A61K9/02 ,  A61K9/08 ,  A61K31/192 ,  A61K31/519 ,  A61K38/10 ,  A61K38/12 ,  A61K45/06 ,  A61K47/02 ,  A61K47/60 ,  C07K7/64

摘要： The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. The gastrointestinal disease may be classified as either inflammatory bowel disease or other GI condition, including Crohn's disease and ulcerative colitis, and cancer.

摘要翻译： 本发明提供新的鸟苷酸环化酶-C激动剂肽及其在治疗包括胃肠道疾病，炎症或癌症（例如胃肠癌））的人类疾病中的用途。 肽可以单独施用或与cGMP依赖性磷酸二酯酶抑制剂组合施用。 胃肠道疾病可以分为肠易激综合征，便秘或过度酸度等。胃肠道疾病可分为炎症性肠病或其他GI病症，包括克罗恩病和溃疡性结肠炎，以及癌症。

公开(公告)号：US10232011B2

公开(公告)日：2019-03-19

申请号：US15924940

申请日：2018-03-19

申请人： SYNERGY PHARMACEUTICALS, INC.

发明人： Stephen Comiskey ,  Rong Feng ,  John Foss ,  Kunwar Shailubhai

IPC分类号： A61K38/10 ,  C07K7/54 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K38/12 ,  A61K45/06 ,  A61K31/192 ,  A61K31/501 ,  A61K31/519 ,  A61K31/53 ,  A61K31/765 ,  A61K31/78 ,  A61K47/12 ,  A61K47/38 ,  C07K7/08 ,  C07K7/64 ,  A61K9/00

摘要： The invention provides low-dose formulations of guanylate cyclase-C (“GCC”) agonist peptides and methods for their use. The formulations of the invention can be administered either alone or in combination with one or more additional therapeutic agents, preferably an inhibitor of cGMP-dependent phosphodiesterase or a laxative.

公开(公告)号：US09920095B2

公开(公告)日：2018-03-20

申请号：US14831293

申请日：2015-08-20

申请人： SYNERGY PHARMACEUTICALS, INC.

发明人： Kunwar Shailubhai ,  Gary S. Jacob

IPC分类号： A61K38/00 ,  C07K7/08 ,  A61K38/10 ,  A61K45/06

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K38/10 ,  A61K45/06

摘要： The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorder, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. The gastrointestinal disease may be classified as either inflammatory bowel disease or other GI condition including Crohn's disease and ulcerative colitis, and cancer.

公开(公告)号：US09814752B2

公开(公告)日：2017-11-14

申请号：US14742456

申请日：2015-06-17

申请人： SYNERGY PHARMACEUTICALS, INC.

发明人： Kunwar Shailubhai

IPC分类号： A61K38/10 ,  A61K45/06 ,  C07K7/08 ,  A61K47/48

CPC分类号： A61K38/10 ,  A61K45/06 ,  A61K47/60 ,  A61P35/00 ,  C07K7/08

摘要： This invention also provides a method to prevent, control, and treat a lipid metabolism disorder, a billary disorder, cardiovascular disease, obesity or an endocrine disorder by administering at least one agonist of guanalyte cyclase receptor either alone or in combination with a compound typically used to treat the disorder and or with an inhibitor of cGMP-dependent phosphodiesterases.

公开(公告)号：US20170129925A1

公开(公告)日：2017-05-11

申请号：US15405787

申请日：2017-01-13

申请人： Synergy Pharmaceuticals Inc.

发明人： Juncai Bai ,  Ruoping Zhang ,  Jun Jian ,  Junfeng Zhou ,  Qiao Zhao ,  Guoquing Zhang ,  Kunwar Shailubhai ,  Stephen Comiskey ,  Rong Feng

IPC分类号： C07K7/64

摘要： The invention provides processes of preparing a peptide including a GCC agonist sequence selected from the group consisting of SEQ ID NOs: 1-249 described herein.

公开(公告)号：US09545446B2

公开(公告)日：2017-01-17

申请号：US14189645

申请日：2014-02-25

申请人： Synergy Pharmaceuticals Inc.

发明人： Dennis Riff ,  Gary S. Jacob ,  Kunwar Shailubhai ,  Patrick H. Griffin

IPC分类号： A61K38/00 ,  C07K9/00 ,  A61K45/06 ,  A61K38/12 ,  A61K38/04 ,  A61K31/53 ,  A61K31/192 ,  A61K31/352 ,  A61K31/4468 ,  A61K31/501 ,  A61K31/519 ,  A61K31/7004

CPC分类号： A61K38/10 ,  A61K9/2873 ,  A61K31/192 ,  A61K31/194 ,  A61K31/352 ,  A61K31/4468 ,  A61K31/501 ,  A61K31/519 ,  A61K31/53 ,  A61K31/7004 ,  A61K33/42 ,  A61K38/04 ,  A61K38/12 ,  A61K45/06 ,  Y02A50/473 ,  A61K2300/00

摘要： This invention provides a method of colonic cleansing.

摘要翻译： 本发明提供一种结肠清洗方法。

公开(公告)号：US08664354B2

公开(公告)日：2014-03-04

申请号：US13955710

申请日：2013-07-31

申请人： Synergy Pharmaceuticals Inc.

发明人： Kunwar Shailubhai

IPC分类号： A61K38/00 ,  A61K38/10

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K38/10 ,  A61K45/06 ,  C07K7/64

摘要： The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. The gastrointestinal disease may be classified as either inflammatory bowel disease or other GI condition including Crohn's disease and ulcerative colitis, and cancer.

摘要翻译： 本发明提供新的鸟苷酸环化酶-C激动剂肽及其在治疗包括胃肠道疾病，炎症或癌症（例如胃肠癌））的人类疾病中的用途。 肽可以单独施用或与cGMP依赖性磷酸二酯酶抑制剂组合施用。 胃肠道疾病可以分为肠易激综合征，便秘或过度酸度等。胃肠道疾病可分为炎症性肠病或其他胃肠道疾病，包括克罗恩病和溃疡性结肠炎，以及癌症。

公开(公告)号：US20140024605A1

公开(公告)日：2014-01-23

申请号：US13857283

申请日：2013-04-05

申请人： Synergy Pharmaceuticals Inc.

发明人： Kunwar Shailubhai ,  Gary S. Jacob

IPC分类号： C07K7/64

CPC分类号： C07K7/08 ,  A61K9/0031 ,  A61K9/02 ,  A61K9/08 ,  A61K31/192 ,  A61K31/519 ,  A61K38/10 ,  A61K38/12 ,  A61K45/06 ,  A61K47/02 ,  A61K47/60 ,  C07K7/64

摘要： The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The gastrointestinal disorder may be classified as irritable bowel syndrome, constipation, or excessive acidity etc. The gastrointestinal disease may be classified as either inflammatory bowel disease or other GI condition, including Crohn's disease and ulcerative colitis, and cancer.

摘要翻译： 本发明提供新的鸟苷酸环化酶-C激动剂肽及其在治疗包括胃肠道疾病，炎症或癌症（例如胃肠癌））的人类疾病中的用途。 肽可以单独施用或与cGMP依赖性磷酸二酯酶抑制剂组合施用。 胃肠道疾病可分为肠易激综合征，便秘或过度酸度等。胃肠道疾病可分为炎性肠病或其他胃肠道疾病，包括克罗恩病和溃疡性结肠炎，以及癌症。