公开(公告)号：US08822949B2

公开(公告)日：2014-09-02

申请号：US13364322

申请日：2012-02-02

申请人： Jordan Krechmer ,  Brian D. Musselman

发明人： Jordan Krechmer ,  Brian D. Musselman

IPC分类号： H01J49/30 ,  H01J37/08 ,  H01J49/12 ,  H01J49/04 ,  H01J27/26

CPC分类号： H01J49/049 ,  G01N27/622 ,  G01N27/626 ,  G01N27/64 ,  H01J27/26 ,  H01J49/004 ,  H01J49/04 ,  H01J49/0431 ,  H01J49/10 ,  H01J49/126 ,  H01J49/14 ,  H01J49/24 ,  Y10T436/24

摘要： The present invention is directed to a method and device to desorb an analyte using heat to allow desorption of the analyte molecules, where the desorbed analyte molecules are ionized with ambient temperature ionizing species. In various embodiments of the invention a current is passed through a mesh upon which the analyte molecules are present. The current heats the mesh and results in desorption of the analyte molecules which then interact with gas phase metastable neutral molecules or atoms to form analyte ions characteristic of the analyte molecules.

摘要翻译： 本发明涉及一种使用热解析分析物以允许分析物分子解吸的方法和装置，其中解吸的分析物分子与环境温度电离物质电离。 在本发明的各种实施方案中，电流通过其上存在分析物分子的网。 电流加热网格并导致分析物分子的解吸，然后分析物分子与气相亚稳态的中性分子或原子相互作用以形成分析物分子特征的分析物离子。

公开(公告)号：US08754365B2

公开(公告)日：2014-06-17

申请号：US13797409

申请日：2013-03-12

申请人： Ionsense Inc.

发明人： Jordan Krechmer ,  Brian D. Musselman

IPC分类号： G01N27/64 ,  H01J49/04 ,  H01J49/00 ,  G01N27/62

CPC分类号： H01J49/049 ,  G01N27/622 ,  G01N27/626 ,  G01N27/64 ,  H01J27/26 ,  H01J49/004 ,  H01J49/04 ,  H01J49/0431 ,  H01J49/10 ,  H01J49/126 ,  H01J49/14 ,  H01J49/24 ,  Y10T436/24

摘要： The present invention is directed to a method and device to desorb an analyte using heat to allow desorption of the analyte molecules, where the desorbed analyte molecules are ionized with ambient temperature ionizing species. In various embodiments of the invention a current is passed through a mesh upon which the analyte molecules are present. The current heats the mesh and results in desorption of the analyte molecules which then interact with gas phase metastable neutral molecules or atoms to form analyte ions characteristic of the analyte molecules.

公开(公告)号：US08729496B2

公开(公告)日：2014-05-20

申请号：US13831957

申请日：2013-03-15

申请人： Brian D. Musselman

发明人： Brian D. Musselman

IPC分类号： G01N27/62 ,  G01N30/02 ,  B01D5/00 ,  H01J27/00

CPC分类号： H01J49/10 ,  G01N1/2214 ,  G01N27/62 ,  H01J49/0027 ,  H01J49/0409

摘要： In various embodiments of the invention, a cargo container can be monitored at appropriate time intervals to determine that no controlled substances have been shipped with the cargo in the container. The monitoring utilizes reactive species produced from an atmospheric analyzer to ionize analyte molecules present in the container which are then analyzed by an appropriate spectroscopy system. In an embodiment of the invention, a sorbent surface can be used to absorb, adsorb or condense analyte molecules within the container whereafter the sorbent surface can be interrogated with the reactive species to generate analyte species characteristic of the contents of the container.

摘要翻译： 在本发明的各种实施例中，可以以适当的时间间隔来监视货物集装箱，以确定货物在集装箱中没有运送受控物质。 监测利用从大气分析仪产生的反应物质电离存在于容器中的分析物分子，然后通过合适的光谱系统进行分析。 在本发明的一个实施方案中，可以使用吸附剂表面来吸收，吸附或冷凝容器内的分析物分子，然后可以用反应性物质询问吸附剂表面以产生容器内容物特征的分析物质。

公开(公告)号：US08440965B2

公开(公告)日：2013-05-14

申请号：US12979729

申请日：2010-12-28

申请人： Brian Musselman

发明人： Brian Musselman

IPC分类号： H01J49/04

CPC分类号： H01J49/04 ,  H01J49/0404 ,  H01J49/16

摘要： The invention provides for efficient collection of analyte ions and neutral molecules from surfaces for their subsequent analysis with spectrometry. In an embodiment of the invention, a ‘multiple desorption ionization source’ includes a tube which can contain ions for subsequent sampling within a defined spatial resolution from desorption ionization at or near atmospheric pressures. In an embodiment, electrostatic fields are used to direct ions a plurality of tubes positioned in close proximity to the surface of the sample being analyzed. In an embodiment of the present invention, either narrow inside diameter capillary tubes or wide diameter tubes can be used in combination with a vacuum inlet to draw ions and neutrals into the spectrometer for analysis. In an embodiment of the invention, a dopant is introduced into a tube to analyze the sample. In an embodiment of the invention, a plurality of ionization sources is used to analyze the sample.

摘要翻译： 本发明提供了从表面有效收集分析物离子和中性分子用于随后的分析。 在本发明的一个实施方案中，“多重解吸电离源”包括管，其可以包含离子，用于在大气压力附近或接近大气压力下的解吸电离的定义的空间分辨率中进行后续取样。 在一个实施例中，使用静电场来引导离子定位在正被分析的样品表面附近的多个管。 在本发明的一个实施例中，窄内径毛细管或宽直径管可以与真空入口组合使用，以将离子和中性粒子吸入光谱仪进行分析。 在本发明的一个实施方案中，将掺杂剂引入管中以分析样品。 在本发明的一个实施例中，使用多个电离源来分析样品。

公开(公告)号：US20120280119A1

公开(公告)日：2012-11-08

申请号：US13530387

申请日：2012-06-22

申请人： Brian D. Musselman

发明人： Brian D. Musselman

IPC分类号： H01J49/26

CPC分类号： H01J49/10 ,  G01N1/2214 ,  G01N27/62 ,  H01J49/0027 ,  H01J49/0409

摘要： In various embodiments of the invention, a cargo container can be monitored at appropriate time intervals to determine that no controlled substances have been shipped with the cargo in the container. The monitoring utilizes reactive species produced from an atmospheric analyzer to ionize analyte molecules present in the container which are then analyzed by an appropriate spectroscopy system. In an embodiment of the invention, a sorbent surface can be used to absorb, adsorb or condense analyte molecules within the container whereafter the sorbent surface can be interrogated with the reactive species to generate analyte species characteristic of the contents of the container.

摘要翻译： 在本发明的各种实施例中，可以以适当的时间间隔来监视货物集装箱，以确定货物在集装箱中没有运送受控物质。 监测利用从大气分析仪产生的反应物质电离存在于容器中的分析物分子，然后通过合适的光谱系统进行分析。 在本发明的一个实施方案中，可以使用吸附剂表面来吸收，吸附或冷凝容器内的分析物分子，然后可以用反应性物质询问吸附剂表面以产生容器内容物特征的分析物质。

公开(公告)号：US20120119082A1

公开(公告)日：2012-05-17

申请号：US13231889

申请日：2011-09-13

申请人： Brian D. Musselman

发明人： Brian D. Musselman

IPC分类号： H01J49/04 ,  H01J27/00

CPC分类号： H01J49/06

摘要： In various embodiments of the invention, a device permits more efficient collection and transmission of ions produced by the action of a carrier gas containing metastable neutral excited-state species into a mass spectrometer. In one embodiment of the invention, the device incorporates the source for ionization in combination with a jet separator to efficiently remove excess carrier gas while permitting ions to be more efficiently transferred into the vacuum chamber of the mass spectrometer. In an embodiment of the invention, improved collection of ions produced by the carrier gas containing metastable neutral excited-state species at greater distances from between the position of the analyte and the position of the mass spectrometer are enabled.

摘要翻译： 在本发明的各种实施例中，装置允许通过含有亚稳态中性激发态物质的载气的作用产生的离子更有效地收集和传输到质谱仪中。 在本发明的一个实施例中，该装置将用于离子化的源与喷射分离器结合，以有效地除去过量的载气，同时允许离子更有效地转移到质谱仪的真空室中。 在本发明的一个实施方案中，能够在分析物的位置与质谱仪的位置之间更远的距离处包含由含有亚稳态中性激发态物质的载气产生的离子的改进收集。

公开(公告)号：US20080067359A1

公开(公告)日：2008-03-20

申请号：US11754189

申请日：2007-05-25

申请人： Brian D. Musselman

发明人： Brian D. Musselman

IPC分类号： B01D59/44

CPC分类号： H01J49/16 ,  H01J49/0404 ,  H01J49/0409 ,  H01J49/0459

摘要： The present invention is a device to restrict the sampling of analyte ions and neutral molecules from surfaces with mass spectrometry and thereby sample from a defined area or volume. In various embodiments of the present invention, a tube is used to sample ions formed with a defined spatial resolution from desorption ionization at or near atmospheric pressures. In an embodiment of the present invention, electrostatic fields are used to direct ions to either individual tubes or a plurality of tubes positioned in close proximity to the surface of the sample being analyzed. In an embodiment of the present invention, wide diameter sampling tubes can be used in combination with a vacuum inlet to draw ions and neutrals into the spectrometer for analysis. In an embodiment of the present invention, wide diameter sampling tubes in combination with electrostatic fields improve the efficiency of ion collection.

摘要翻译： 本发明是一种通过质谱法将分析物离子和中性分子从表面进行取样从而限定区域或体积的样品的装置。 在本发明的各种实施方案中，使用管来在大气压力或接近大气压下从解吸离子中采集以定义的空间分辨率形成的离子。 在本发明的一个实施例中，使用静电场来将离子引导到被分析的样品表面附近的单个管或多个管。 在本发明的一个实施例中，宽直径采样管可以与真空入口组合使用，以将离子和中性粒子吸入光谱仪进行分析。 在本发明的一个实施例中，与静电场相结合的宽直径采样管提高了离子收集的效率。

公开(公告)号：US20190371592A1

公开(公告)日：2019-12-05

申请号：US16422339

申请日：2019-05-24

申请人： IonSense Inc.

发明人： Brian D Musselman

IPC分类号： H01J49/14

摘要： In an embodiment of the present ambient ionization experiment, the abundance of background chemicals relative to ions of interest is decreased by reducing the overall abundance of background chemicals introduced into the ionizing region. In an embodiment of the present invention, the reduction of unwanted background chemicals in the ionization region can be effected by limiting the area which the sample volume is deposited. In an embodiment of the present invention, the reduction of unwanted background chemicals in the ionization region can be effected by decreasing the duration of time that the sample is exposed to the atmospheric pressure ionization source. In an embodiment of the present invention, the reduction of unwanted background chemicals in the ionization region can be effected by limiting the sample volume. In an embodiment of the present invention dilution of the sample with water can be used to reduce the contribution of the background chemicals. In an embodiment of the present ambient ionization experiment, an ion intensifier is used to suppress ionization of background chemicals to permit more efficient ionization and detection of the molecules of interest.

公开(公告)号：US20190252177A1

公开(公告)日：2019-08-15

申请号：US16388784

申请日：2019-04-18

申请人： IONSENSE INC.

发明人： BRIAN D MUSSELMAN

IPC分类号： H01J49/16 ,  H01J49/00 ,  H01J49/04 ,  G01N1/40

CPC分类号： H01J49/165 ,  G01N1/4022 ,  G01N2001/028 ,  G01N2030/009 ,  G01N2030/062 ,  H01J49/0031 ,  H01J49/045 ,  H01J49/16

摘要： The present invention is directed to a method and device to generate a chemical signature for a mixture of analytes. The present invention involves using a SPME surface to one or both absorb and adsorb the mixture of analytes. In an embodiment of the invention, the surface is then exposed to different temperature ionizing species chosen with appropriate spatial resolution to desorb a chemical signature for the mixture of analytes.

公开(公告)号：US20190013190A1

公开(公告)日：2019-01-10

申请号：US16029353

申请日：2018-07-06

申请人： IonSense Inc.

发明人： Brian D. Musselman

IPC分类号： H01J49/04 ,  B01J20/281 ,  H01J49/10 ,  G01N30/72

摘要： In various embodiments of the invention, a sorbent coated mesh or grid introduced into contact with a sample can be monitored at appropriate temperatures, positions and time intervals to determine species present in the sample. The monitoring utilizes reactive species produced from an atmospheric analyzer to ionize analyte molecules present on the sorbent coated mesh or grid which are then analyzed by an appropriate spectroscopy system. In an embodiment of the invention, a sorbent surface can be used to absorb, adsorb or condense analyte molecules from the sample whereafter the sorbent surface can be interrogated with the reactive species to generate analyte species characteristic of the sample.