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公开(公告)号：US12036278B2
公开(公告)日：2024-07-16
申请号：US18103214
申请日：2023-01-30
发明人： Aladar Szalay , Boris Minev
IPC分类号： A61K39/285 , A61K35/35 , A61K35/76 , A61K39/12 , A61K39/00
CPC分类号： A61K39/285 , A61K35/35 , A61K35/76 , A61K39/12 , A61K2039/515 , A61K2039/525 , A61K2039/5254 , A61K2039/55 , A61K2039/585 , A61K2039/6006 , C12N2710/24134
摘要： Disclosed herein are methods and compositions related to therapy for cancer. More specifically, the disclosed methods and compositions are related to the use of smallpox vaccine to induce an effective anti-tumor immune response.
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公开(公告)号：US20240226203A9
公开(公告)日：2024-07-11
申请号：US18351930
申请日：2023-07-13
发明人： Dinah Wen-Yee Sah , Fen Chen , Pengcheng Zhou , Xin Wang , Yanqun Shu , Jinzhao Hou , Jochen Deckert , Markus Hossbach
IPC分类号： A61K35/76 , A61P25/14 , C12N7/00 , C12N15/113 , C12N15/86
摘要： The present invention relates to adeno-associated viral (AAV) particles encoding siRNA molecules and methods for treating Huntington's Disease (HD).
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13.发明公开公开(公告)号：US20240226202A9
公开(公告)日：2024-07-11
申请号：US18277879
申请日：2021-06-15
发明人： Jong Soo JEON , Ji Eun KIM , Jun Ok MOON , Jong Pyo CHAE , Yu Jin KIM , Seung Eun LEE
摘要： The present application relates to a novel bacteriophage having Clostridium perfringens-specific bactericidal effect and an antibacterial composition comprising same, the novel bacteriophage CJ_CP_20-11-1 having Clostridium perfringens-specific bactericidal effect, and being superbly acid and heat resistant to allow wide use in antibiotics, feed and additives therefor, beverages and additives therefor, disinfectants, detergents, and the like to prevent or treat infectious diseases caused by Clostridium perfringens.
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14.发明公开公开(公告)号：US20240216450A1
公开(公告)日：2024-07-04
申请号：US18277873
申请日：2021-06-15
发明人： Jong Soo JEON , Ji Eun KIM , Jun Ok MOON , Jong Pyo CHAE , Yu Jin KIM , Seung Eun LEE
摘要： The present application relates to a novel bacteriophage having Clostridium perfringens-specific bactericidal effect and an antibacterial composition comprising same, the novel bacteriophage CJ_CP_20-15 having Clostridium perfringens-specific bactericidal effect, and being superbly acid and heat resistant to allow wide use in antibiotics, feed and additives therefor, beverages and additives therefor, disinfectants, detergents, and the like to prevent or treat infectious diseases caused by Clostridium perfringens.
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公开(公告)号：US12006517B2
公开(公告)日：2024-06-11
申请号：US17571645
申请日：2022-01-10
发明人： Joseph Robert Fackler , Carl Merril , Jarrar Haider , Viet Dang
CPC分类号： C12N7/00 , A61K35/76 , A61P31/04 , B01D61/20 , B01D69/08 , B01D2311/2676 , B01D2311/2688 , B01D2315/10 , C12N2795/10132 , C12N2795/10151 , C12N2795/10232 , C12N2795/10251 , C12N2795/10332 , C12N2795/10351
摘要： A method of recovering viable phage from, for example, a crude phage preparation such as a lysate resulting from amplification of phage in bacterial cell culture is disclosed. The method may be “universal”; that is, applicable to the purification of a broad range of phage species and strains. The phage product resulting from the method may have an acceptably low endotoxin titer (e.g. less than 500 EU/ml) and sufficiently high phage titer (e.g. >1×109 PFU/ml) for use in therapeutic applications.
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公开(公告)号：US20240141381A1
公开(公告)日：2024-05-02
申请号：US18379015
申请日：2023-10-11
发明人： Tyler Lahusen , Charles David Pauza
CPC分类号： C12N15/86 , A61K35/76 , C12N9/0071 , C12Y114/16001 , A61K48/00
摘要： A lentiviral vector system for expressing a lentiviral particle is disclosed. The lentiviral vector system includes a therapeutic vector. The therapeutic vector comprises a phenylalanine hydroxylase (PAH) sequence for expressing at least one of PAH or a variant thereof, wherein the PAH sequence is truncated.
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17.发明公开公开(公告)号：US20240141302A1
公开(公告)日：2024-05-02
申请号：US18278567
申请日：2021-06-15
发明人： Jong Soo JEON , Ji Eun KIM , Jun Ok MOON , Jong Pyo CHAE , Yu Jin KIM , Seung Eun LEE , Jin Seung PARK
CPC分类号： C12N7/00 , A01N63/40 , A01P1/00 , A61K35/76 , A61P31/04 , C11D3/381 , C12N2795/00031 , C12N2795/00032
摘要： The present application relates to a novel bacteriophage having enterotoxigenic Escherichia coli-specific bactericidal effect and an antibacterial composition comprising same, the novel bacteriophage CJ_Eco_20-4 having enterotoxigenic Escherichia coli-specific bactericidal effect, and being superbly acid and heat resistant to allow wide use in antibiotics, feed and additives therefor, beverages and additives therefor, disinfectants, detergents, and the like to prevent or treat infectious diseases caused by enterotoxigenic Escherichia coli.
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18.发明公开公开(公告)号：US20240131094A1
公开(公告)日：2024-04-25
申请号：US18546690
申请日：2022-02-18
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. , Otto-von-Guericke-Universität Magdeburg , Helmholtz-Zentrum für Infektionsforschung GmbH
发明人： Sascha KUPKE , Udo REICHL , Marc Dominique HEIN , Dunja BRUDER , ulfert RAND
摘要： In The present invention relates in a first aspect to the use of influenza virus defective interfering particles in the prophylactic or therapeutic treatment of coronaviridae infection. In particular, it has been recognized that defective interfering particles of influenza A have beneficial effects in the treatment of SARS coronavirus infection, in particular, SARS-CoV-2 infection. Further, the present invention relates to a pharmaceutical composition for use in treating coronaviridae infection, in particular SARS-CoV-2. In a further aspect, methods for the prophylactic or therapeutic treatments of coronaviridae based on the administration of DIFs are disclosed.
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19.发明授权公开(公告)号：US11932679B2
公开(公告)日：2024-03-19
申请号：US16329631
申请日：2017-09-01
IPC分类号： C07K14/72 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K48/00 , A61P27/02 , C07K14/195 , C07K14/705 , C07K19/00 , C12N15/09 , C12N15/86
CPC分类号： C07K14/723 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K48/00 , A61P27/02 , C07K14/195 , C12N15/09 , C12N15/86 , C07K14/705 , C07K19/00 , C12N2750/14143
摘要： The purpose of the present invention is to provide an agent for restoring a visual function or an agent for preventing the deterioration in a visual function, which has an excellent visual function restoring ability. The agent for regenerating a visual function or the agent for preventing the deterioration in a visual function according to the present invention contains, as an active ingredient, a chimeric protein having both an amino acid sequence for a microorganism-origin ion-transporting receptor rhodopsin and an amino acid sequence for an animal-origin G-protein-coupled receptor rhodopsin. The chimeric protein is preferably one in which an amino acid sequence for a cytoplasm-side second loop and/or a cytoplasm-side third loop in the amino acid sequence for the microorganism-origin ion-transporting receptor rhodopsin is substituted by an amino acid sequence for a cytoplasm-side second loop and/or a cytoplasm-side third loop in the G-protein-coupled receptor rhodopsin.
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公开(公告)号：US20240082328A1
公开(公告)日：2024-03-14
申请号：US18493396
申请日：2023-10-24
申请人： SYNTBIOLAB INC
发明人： Rodrigue DUBAR , Simon LABRIE
CPC分类号： A61K35/76 , A23K10/18 , A61P31/04 , C12N7/00 , C12N2795/00032 , C12N2795/00051
摘要： The present invention provides new bacteriophages, their selection, compositions, cocktails and formulations thereof, and their administration for the prevention of opportunistic infections in livestock, such as Avian Pathogenic E. Coli (APEC) infections in poultry.
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