公开(公告)号：US20240301031A1

公开(公告)日：2024-09-12

申请号：US18284009

申请日：2022-03-31

Applicant: JIANGSU HENGRUI PHARMACEUTICALS CO., LTD. ,  SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.

Inventor： Langyong MAO ,  Hua YING ,  Xinsheng JIN ,  Lingling LI ,  Weikang TAO

IPC: C07K14/715 ,  A61K39/00 ,  A61P37/02 ,  C07K16/24

CPC classification number: C07K14/7151 ,  A61P37/02 ,  C07K16/244 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/30

Abstract: The present application relates to a truncated TACI polypeptide and a fusion protein and use thereof. Specifically, provided are a TACI polypeptide as shown in SEQ ID NO: 8, a truncated fragment thereof, a mutation sequence thereof, and a fusion protein comprising the TACI polypeptide and use thereof.

公开(公告)号：US12084489B2

公开(公告)日：2024-09-10

申请号：US17052470

申请日：2019-05-02

Applicant: The U.S.A., as represented by the Secretary, Department of Health and Human Services ,  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

Inventor： Masaru Kanekiyo ,  Michael Gordon Joyce ,  Wei Bu ,  Jeffrey I. Cohen ,  Yaroslav Tsybovsky

IPC: C07K16/08 ,  A61K47/68 ,  C12Q1/70 ,  G01N33/569

CPC classification number: C07K16/085 ,  A61K47/6803 ,  A61K47/6839 ,  C12Q1/705 ,  G01N33/56994 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C12Q2600/158 ,  G01N2333/05 ,  G01N2800/26

Abstract: Anti-EBV gH antibodies, anti-EBV gL antibodies, anti-EBV gH/gL antibodies, and compositions of matter useful for the detection, diagnosis, prevention, and treatment of Epstein Barr Virus infection in humans, and methods of using those compositions of matter for the same.

公开(公告)号：US20240294672A1

公开(公告)日：2024-09-05

申请号：US18590651

申请日：2024-02-28

Applicant: Chugai Seiyaku Kabushiki Kaisha

Inventor： Junichi Nezu ,  Takahiro Ishiguro ,  Atsushi Narita ,  Akihisa Sakamoto ,  Yumiko Kawai ,  Tomoyuki Igawa ,  Taichi Kuramochi

IPC: C07K16/46 ,  A61K39/00 ,  C07K16/28 ,  C07K16/30

CPC classification number: C07K16/46 ,  C07K16/2809 ,  C07K16/2863 ,  C07K16/30 ,  C07K16/303 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/30

Abstract: Disclosed are bispecific antibodies with heavy chain constant regions having the sequence of an IgG1 constant region with one or more mutations including one or more substitutions that reduce the ability of the heavy chain constant regions to bind to a human Fcγ receptor.

公开(公告)号：US20240294662A1

公开(公告)日：2024-09-05

申请号：US18647183

申请日：2024-04-26

Applicant: Novartis AG ,  The Trustees of the University of Pennsylvania

Inventor： Gregory Beatty ,  Boris Engels ,  Neeraja Idamakanti ,  Carl H. June ,  Andreas Loew ,  Huijuan Song ,  Qilong Wu

IPC: C07K16/30 ,  A61K31/436 ,  A61K38/00 ,  A61K38/17 ,  A61K39/00 ,  A61K39/395 ,  A61K48/00 ,  C07K14/705 ,  C07K14/715 ,  C07K14/725 ,  C12N5/0783 ,  C12N15/85 ,  C12N15/86

CPC classification number: C07K16/30 ,  A61K31/436 ,  A61K38/1774 ,  A61K38/1793 ,  A61K39/001168 ,  A61K39/39558 ,  A61K48/0058 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/7151 ,  C07K16/303 ,  C07K16/3061 ,  C07K16/3069 ,  C12N5/0638 ,  C12N15/85 ,  C12N15/86 ,  A61K38/00 ,  A61K2039/505 ,  A61K2039/5158 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/74 ,  C12N2740/15041

Abstract: Provided are compositions and methods for treating diseases associated with expression of mesothelin. Also provided are a chimeric antigen receptor (CAR) specific to mesothelin, vectors encoding the same, and recombinant T cells comprising the mesothelin CAR. Further provided are methods of administering a genetically modified T cell expressing a CAR that comprises a mesothelin binding domain.

公开(公告)号：US20240294659A1

公开(公告)日：2024-09-05

申请号：US18645607

申请日：2024-04-25

Applicant: OSE Immunotherapeutics

Inventor： Nicolas Poirier ,  Bernard Vanhove

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  G01N33/50

CPC classification number: C07K16/2896 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/2803 ,  G01N33/5011 ,  G01N33/5023 ,  A61K2039/505 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2317/76 ,  G01N2500/02

Abstract: The present invention pertains to the field of immunotherapy. More specifically, the present invention provides a method for differentiating myeloid-derived suppressor cells (MDSC) into non suppressive cells, by administering a compound blocking the interaction between SIRPα and CD47 to a patient in need thereof, in order to reduce MDSC-induced immunodepression and consequently allow appropriate immune responses in cancers, infectious diseases, vaccination, trauma, autoimmune diseases, chronic inflammatory diseases and transplantation.

公开(公告)号：US20240294600A1

公开(公告)日：2024-09-05

申请号：US18654279

申请日：2024-05-03

Applicant: Cartesian Therapeutics, Inc.

Inventor： Yi Zhang ,  C. Andrew Stewart ,  Metin Kurtoglu ,  Murat V. Kalayoglu ,  Michael S. Singer

IPC: C07K14/705 ,  A61K39/00 ,  A61K39/395 ,  C07K16/28 ,  C07K16/30

CPC classification number: C07K14/70517 ,  A61K39/3955 ,  A61K39/39558 ,  C07K16/2878 ,  C07K16/2896 ,  C07K16/30 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/03

Abstract: Provided herein are chimeric antigen receptors (CARs), such as those specific for BCMA, that have improved properties, including increased CAR T cell binding to BCMA and improved CAR T cell killing of BCMA-expressing cancer cells. Use of the CARs in immune cells (e.g., T cells), compositions (e.g., CARs and nucleic acid constructs encoding the same), and methods are also contemplated.

公开(公告)号：US20240293544A1

公开(公告)日：2024-09-05

申请号：US18558701

申请日：2021-11-17

Applicant: KIROMIC BIOPHARMA, INC.

Inventor： Lucia PICCOTTI ,  Leonardo MIRANDOLA ,  Maurizio CHIRIVA-INTERNATI ,  David SPENCER ,  Xiaohong WANG ,  Yibin CHEN

IPC: A61K39/00 ,  A61K31/675 ,  A61K31/7076 ,  A61P35/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/30 ,  C12N5/0783

CPC classification number: A61K39/4631 ,  A61K31/675 ,  A61K31/7076 ,  A61K39/4611 ,  A61K39/4613 ,  A61K39/464468 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K14/70596 ,  C07K16/30 ,  C12N5/0636 ,  C12N5/0646 ,  A61K2239/38 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2319/02 ,  C07K2319/03 ,  C12N2510/00

Abstract: The technology relates in part to binding molecules that specifically bind to a polypeptide that is the Isoform 2 of mesotheiin, or that specifically bind to an antigenic determinant (epitope) of the isoform 2 of mesotheiin, or that specifically bind to polypeptides containing an antigenic determinant (epitope) of the isoform 2 of mesotheiin, chimeric PD1 receptors that bind to PD ligands such as PDLs, to polynucleotides including vectors that encode such binding molecules, to ceils presenting such binding molecules and to methods of making such cells, to humanized forms of the binding molecules, and to methods of using such binding molecules, such as for treating cancers (e.g., ovarian cancers and mesotheliomas), including cancers in which the Isoform 2 of mesotheiin is specifically expressed and/or upregulated relative to normal tissues.

公开(公告)号：US20240287206A1

公开(公告)日：2024-08-29

申请号：US18568180

申请日：2022-06-10

Applicant: NIBEC CO., LTD. ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

Inventor： Yoon Jeong PARK ,  Chong-Pyoung CHUNG ,  Jue-Yeon LEE ,  Gook-Jin YOON

IPC: C07K16/40 ,  C07K14/47

CPC classification number: C07K16/40 ,  C07K14/47 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/01 ,  C07K2319/95

Abstract: The present invention relates to a proteolysis targeting chimera (PROTAC) protein having an intracellular delivery function, and a pharmaceutical composition comprising same. The PROTAC protein according to the present invention has higher solubility than a PROTAC prepared by a conventional method and efficiently degrades intrinsic disease proteins when applied to cells, and thus is effective in the treatment of cancer or inflammatory diseases.

公开(公告)号：US12071484B2

公开(公告)日：2024-08-27

申请号：US16924282

申请日：2020-07-09

Applicant: CSL LIMITED

Inventor： Andrew Donald Nash ,  Arna Elizabeth Andrews ,  Manuel Baca ,  Kirsten Mae Edwards ,  Matthew Philip Hardy ,  Con Panousis ,  Felicity Meredith Dunlop

IPC: C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2866 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present disclosure provides proteins comprising antigen binding domains of antibodies that bind to human granulocyte-colony stimulating factor receptor.

公开(公告)号：US12060415B2

公开(公告)日：2024-08-13

申请号：US17592828

申请日：2022-02-04

Applicant: Rutgers, The State University of New Jersey

Inventor： Renata Pasqualini ,  Wadih Arap ,  Fernanda Iamassaki Staquicini ,  Fortunato Ferrara ,  Sara D'Angelo ,  Andrew R. M. Bradbury

IPC: C07K16/18 ,  A61K39/395 ,  A61P35/00 ,  C07K16/30 ,  G01N33/574 ,  A61K38/07 ,  A61K39/00 ,  A61K47/68 ,  A61K49/00 ,  C07K14/47 ,  C07K16/00 ,  C07K16/28 ,  C12N15/10 ,  C12N15/64 ,  C12Q1/6869 ,  G01N33/50

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K39/39558 ,  A61P35/00 ,  C07K16/30 ,  C07K16/3023 ,  G01N33/574 ,  A61K38/07 ,  A61K2039/505 ,  A61K47/6803 ,  A61K47/6817 ,  A61K47/6843 ,  A61K47/6849 ,  A61K47/6891 ,  A61K49/0008 ,  C07K14/47 ,  C07K16/005 ,  C07K16/28 ,  C07K16/2866 ,  C07K2317/21 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/77 ,  C12N15/1037 ,  C12N15/64 ,  C12N2810/00 ,  C12Q1/6869 ,  G01N33/5011 ,  G01N33/57423

Abstract: Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided.