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    SYSTEM FOR SCREENING PARTICLES
    13.
    发明申请
    SYSTEM FOR SCREENING PARTICLES 审中-公开
    筛选颗粒系统

    公开(公告)号：US20160187323A1

    公开(公告)日：2016-06-30

    申请号：US14993769

    申请日：2016-01-12

    申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    发明人： Omid C. Farokhzad ,  Aleksandar Filip Radovic-Moreno ,  Robert S. Langer

    IPC分类号： G01N33/50

    CPC分类号： G01N33/5088 ,  A61K47/555 ,  A61K47/66 ,  A61K47/6891 ,  B82Y5/00 ,  B82Y15/00 ,  C40B30/06

    摘要： Screening of a library of particles in vivo and/or in vitro using Polyplex Iterative Combinatorial Optimization (PICO) allows for the design of particles for targeting a specific organ, tissue (e.g., cancer), or cell. Particles may, for example, include different targeting agents (e.g., aptamers or plurality of aptamers) on their surfaces, and the aptamer or aptamers may be evolved to provide better targeting of the particles. Libraries of particles are enriched in characteristics of particles that have been found to migrate to a tissue of interest, be taken up by cells, etc. The process may be repeated to engineer particles of a desired specificity or biological function.

    摘要翻译： 使用Polyplex迭代组合优化（PICO）在体内和/或体外筛选粒子库允许设计用于靶向特定器官，组织（例如癌症）或细胞的颗粒。 例如，颗粒可以在其表面上包括不同的靶向剂（例如，适体或多个适配体），并且适配体或适体可以进化以提供更好的颗粒靶向。 已经发现已经发现迁移到感兴趣的组织，被细胞吸收的颗粒的特征的颗粒的富集等。可以重复该过程来设计具有所需特异性或生物学功能的颗粒。

    Compounds Useful for Promoting Protein Degradation and Methods Using Same
    16.
    发明申请
    Compounds Useful for Promoting Protein Degradation and Methods Using Same 审中-公开
    用于促进蛋白质降解的化合物和使用其的方法

    公开(公告)号：US20160022642A1

    公开(公告)日：2016-01-28

    申请号：US14808698

    申请日：2015-07-24

    申请人： Yale University

    发明人： Craig M. Crews ,  Jeffrey Gustafson ,  Anke Gundula Roth ,  Hyun Seop Tae ,  Dennis Buckley ,  Taavi Neklesa

    IPC分类号： A61K31/4166 ,  A61K45/06 ,  C07D233/86

    CPC分类号： A61K31/4166 ,  A61K45/06 ,  A61K47/54 ,  A61K47/555 ,  C07D233/86 ,  A61K2300/00

    摘要： The present description includes compounds that act as degraders of a target protein, wherein degradation is independent of the class of the target protein or its localization. In certain embodiments, the description includes a compound comprising a protein degradation moiety covalently bound to a linker, wherein the ClogP of the compound is equal to or higher than 1.5. The target protein contemplated within the description comprises an androgen receptor. Compounds of the present description may be used to treat disease states wherein protein degradation is a viable therapeutic approach, such as cancer or any sort of oxidative stress disease state.

    摘要翻译： 本描述包括作为靶蛋白的降解物的化合物，其中降解与靶蛋白的类别或其定位无关。 在某些实施方案中，描述包括包含与接头共价结合的蛋白质降解部分的化合物，其中化合物的ClogP等于或高于1.5。 描述中考虑的靶蛋白包括雄激素受体。 本说明书的化合物可用于治疗疾病状态，其中蛋白质降解是可行的治疗方法，例如癌症或任何种类的氧化应激疾病状态。