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公开(公告)号：US11976097B2
公开(公告)日：2024-05-07
申请号：US18046485
申请日：2022-10-13
Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
Inventor： Richard Malley , Yingjie Lu , Fan Zhang
CPC classification number: C07K14/31 , A61K39/092 , A61K39/385 , A61K47/543 , A61K47/557 , A61K47/61 , A61P31/04 , A61K2039/55505 , A61K2039/6031 , A61K2039/6093 , A61K2039/625 , A61K2039/627 , A61K2039/645 , A61K2039/70 , C07K2319/00 , C07K2319/20 , Y02A50/30
Abstract: The disclosure provides modified biotin-binding proteins which can be expressed in soluble form in high yield in bacteria. Also provided are fusion proteins comprising the modified biotin-binding protein and an antigen. The disclosure further provides non-hemolytic variants of alpha-hemolysin from S. aureus and fusion protein comprising non-hemolytic variant of alpha-hemolysin and a biotin-binding domains. Immunogenic compositions comprising the proteins are also disclosed and use of such immunogenic compositions for inducing an immune response or for vaccinating a subject are also disclosed.
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公开(公告)号：US20240139300A1
公开(公告)日：2024-05-02
申请号：US18471733
申请日：2023-09-21
Applicant: OSIVAX
Inventor： Alexandre LE VERT , Judith DEL CAMPO , Fergal HILL , Francesco DORO
CPC classification number: A61K39/0011 , A61P35/00 , A61K2039/53 , A61K2039/6031 , A61K2039/70
Abstract: The invention relates to immunogenic or vaccine compositions and their use in particular in the prevention or treatment of infectious or cancer disorders. More specifically, the immunogenic or vaccine compositions of the present invention comprises a ribonucleic acid (RNA) molecule comprising an open-reading frame encoding a fusion protein, wherein said fusion protein comprises or essentially consists of:
(i) a first polypeptide domain comprising either
a. an antigen or a fragment thereof comprising at least one epitope of said antigen,
b. a peptide moiety comprising a single epitope of an antigen, or
c. a plurality of peptide moieties, wherein each peptide moiety comprises an epitope of an antigen and wherein said peptide moieties are fused together, optionally via peptide linker,
said first polypeptide domain being fused to
(ii) a second polypeptide domain comprising a C4bp-derived oligomerization domain and a positively charged tail.-
公开(公告)号：US11969466B2
公开(公告)日：2024-04-30
申请号：US18314052
申请日：2023-05-08
Inventor： John R. Mascola , Jeffrey C. Boyington , Hadi M. Yassine , Peter D. Kwong , Barney S. Graham , Masaru Kanekiyo
IPC: A61K39/145 , A61K39/12 , C07K14/005 , C07K14/47 , C12N7/00 , A61K39/00
CPC classification number: A61K39/145 , A61K39/12 , C07K14/005 , C07K14/47 , C12N7/00 , A61K2039/55555 , A61K2039/55566 , A61K2039/6031 , C07K2319/00 , C12N2760/16122 , C12N2760/16134
Abstract: Vaccines that elicit broadly protective anti-influenza antibodies. Some vaccines comprise nanoparticles that display HA trimers from influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to the stem region of an influenza HA protein. The fusion proteins self-assemble to form the HA-displaying nanoparticles. The vaccines comprise only the stem region of an influenza HA protein joined to a trimerization domain. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.
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14.发明授权公开(公告)号：US11957762B2
公开(公告)日：2024-04-16
申请号：US15577998
申请日：2016-05-27
Applicant: University of Utah Research Foundation
Inventor： Mingnan Chen , Hyung Jin Cho , Peng Wang , Shuyun Dong , Peng Zhao
IPC: A61K47/64 , A61K31/337 , A61K31/35 , A61K38/00 , A61K39/00 , A61P35/00 , A61P35/04 , C07K14/77 , C07K14/78
CPC classification number: A61K47/6435 , A61K31/337 , A61K31/35 , A61K39/0005 , A61K47/64 , A61P35/00 , A61P35/04 , C07K14/77 , C07K14/78 , A61K38/00 , A61K2039/6031 , C07K2319/00
Abstract: Disclosed herein, are recombinant polypeptides comprising one or more homologous amino acid repeats; and, non-immunogenic bioconjugates comprising recombinant polypeptides comprising one or more homologous amino acid repeats and one or more therapeutic agents. Also, disclosed herein are pharmaceutical compositions including the recombinant polypeptides; and methods of administering the recombinant polypeptides to patients for the treatment of cancer or infections.
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公开(公告)号：US11938221B2
公开(公告)日：2024-03-26
申请号：US17519142
申请日：2021-11-04
Inventor： Barney S. Graham , Masaru Kanekiyo , Hadi M. Yassine
IPC: A61K39/12 , A61K9/16 , A61K39/145 , C12N7/00 , A61K39/00
CPC classification number: A61K9/167 , A61K39/12 , A61K39/145 , C12N7/00 , A61K2039/575 , A61K2039/6031 , A61K2039/6068 , A61K2039/6075 , A61K2039/70 , C12N2760/16134 , C12N2760/16171 , Y02A50/30
Abstract: Novel, nanoparticle-based vaccines are provided that elicit an immune response to a broad range of infectious agents, such as influenza viruses. The nanoparticles comprise a heterogeneous population of fusion proteins, each comprising a monomeric subunit of a self-assembly protein, such as ferritin, joined to one or more immunogenic portions of a protein from an infectious agent, such as influenza virus. The fusion proteins self-assemble to form nanoparticles that display a heterogeneous population of immunogenic portions on their surface. When administered to an individual, such nanoparticles elicit an immune response to different strains, types, subtypes and species with in the same taxonomic family. Thus, such nanoparticles can be used to vaccinate an individual against infection by different Types, subtypes and/or strains of infectious agents. Also provided are specific fusion proteins, nucleic acid molecules encoding such fusion proteins and methods of using nanoparticles of the invention to vaccinate individuals.
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Patent Agency Ranking
公开(公告)号：US11904014B2
公开(公告)日：2024-02-20
申请号：US17089172
申请日：2020-11-04
Applicant: ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS , UNIVERSITÉ PARIS 13
Inventor： Antoine Carpentier , Claire Banissi
IPC: A61K39/385 , A61K39/00
CPC classification number: A61K39/385 , A61K2039/55511 , A61K2039/55516 , A61K2039/572 , A61K2039/575 , A61K2039/6031 , A61K2039/6093
Abstract: The invention relates to the use of melanin, complexed with an antigen, as a immunostimulatory composition.
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17.发明授权公开(公告)号：US11839661B2
公开(公告)日：2023-12-12
申请号：US16639467
申请日：2018-08-15
Applicant: BRANDEIS UNIVERSITY
Inventor： Bing Xu , Huaimin Wang
IPC: A61K47/69 , A61P35/00 , A61K9/00 , A61K31/573 , A61K31/704 , A61K39/39 , A61K45/06 , C07K7/06 , C07K7/08 , A61K39/00
CPC classification number: A61K47/6903 , A61K9/0014 , A61K31/573 , A61K31/704 , A61K39/39 , A61K45/06 , A61P35/00 , C07K7/06 , C07K7/08 , A61K2039/6031
Abstract: Disclosed are a peptide capable of induced self-assembly by a bioactive molecule comprising a (i) hydrogelation-promoting amino acid sequence and (ii) an oligomerization sequence; compositions containing the peptide and, optionally, bioactive molecule; hydrogels formed thereby; and various methods of using the same.
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公开(公告)号：US20230310563A1
公开(公告)日：2023-10-05
申请号：US18048403
申请日：2022-10-20
Applicant: Gritstone bio, Inc.
Inventor： Karin Jooss , Amy Rachel Rappaport , Ciaran Daniel Scallan , Leonid Gitlin
CPC classification number: A61K39/001192 , C12N15/86 , A61K39/001156 , A61P37/04 , C12N2710/10043 , C12N2770/36143 , C12N2830/50 , A61K2039/5256 , A61K2039/6031
Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences having multiple repeats of distinct epitope-encoding sequences or having antigen-encoding nucleic acid sequences having less than 700 nucleotides and encoding multiple distinct epitope-encoding sequences. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.
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公开(公告)号：US11773141B2
公开(公告)日：2023-10-03
申请号：US17053835
申请日：2019-05-09
Applicant: CLEARB THERAPEUTICS LTD. , MELBOURNE HEALTH
Inventor： Renae Walsh , Stephen Locarnini , Hans Netter , Ronald Farquhar
IPC: A61K39/29 , A61K39/295 , C12Q1/70 , A61K39/00 , A61K39/385 , C07K14/005 , A61P31/20 , C12N7/00
CPC classification number: C07K14/005 , A61K39/292 , A61P31/20 , C12N7/00 , A61K2039/6031 , C07K2319/00 , C12N2730/10122 , C12N2730/10123 , C12N2730/10134 , C12N2730/10171
Abstract: Disclosed herein are compositions and methods for the treatment of hepatitis B infection, including chronic hepatitis B (CHB).
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公开(公告)号：US20230233662A1
公开(公告)日：2023-07-27
申请号：US18299676
申请日：2023-04-12
Applicant: CureVac SE
Inventor： Karl-Josef KALLEN , Thomas KRAMPS , Margit SCHNEE , Benjamin PETSCH , Lothar STITZ
IPC: A61K39/155 , A61K39/12 , A61K39/145 , A61K47/59 , A61K47/64 , A61K47/69 , A61P31/16 , A61K39/00 , A61K45/06
CPC classification number: A61K39/155 , A61K39/12 , A61K39/145 , A61K47/59 , A61K47/6455 , A61K47/6921 , A61P31/16 , A61K39/00 , A61K45/06 , A61K2039/53 , A61K2039/55 , A61K2039/572 , C12N2760/16134 , Y02A50/30 , A61K2039/54 , A61K2039/55583 , A61K2039/575 , A61K2039/6031 , A61K2039/622 , C12N2760/18534 , C12N2760/18571
Abstract: The present invention relates to vaccines comprising at least one mRNA encoding at least one antigen for use in the treatment of a disease in newborns and/or infants, preferably exhibiting an age of not more than 2 years, preferably of not more than 1 year, more preferably of not more than 9 months or even 6 months, wherein the treatment comprises vaccination of the newborn or infant and eliciting an immune response in said newborn or infant. The present invention is furthermore directed to kits and kits of parts comprising such a vaccine and/or its components and to methods applying such a vaccine or kit.
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