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    GENOMIC CLASSIFIERS FOR NON-INVASIVE IDENTIFICATION OF HIGH GRADE PROSTATE CANCER WITH METASTATIC POTENTIAL
    12.
    发明申请
    GENOMIC CLASSIFIERS FOR NON-INVASIVE IDENTIFICATION OF HIGH GRADE PROSTATE CANCER WITH METASTATIC POTENTIAL 审中-公开
    用于非侵入性识别具有分化潜力的高级前列腺癌的基因组分类器

    公开(公告)号：US20150299807A1

    公开(公告)日：2015-10-22

    申请号：US14646427

    申请日：2013-11-21

    申请人： THE JOHNS HOPKINS UNIVERSITY

    发明人： Ashley E. ROSS ,  Edward M. SCHAEFFER

    IPC分类号： C12Q1/68 ,  A61B5/15 ,  A61B10/00 ,  G01N33/574

    CPC分类号： C12Q1/6886 ,  A61B5/15 ,  A61B10/0038 ,  A61B10/0058 ,  A61B10/007 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/57434 ,  G01N2800/56 ,  H01J49/0036

    摘要： The present invention relates to the field of biomarkers. More specifically, the present invention provides methods and compositions useful for diagnosing and/or prognosing prostate cancer. In a specific embodiment, a method for diagnosing prostate cancer or a likelihood thereof in a patient comprising the steps of (a) obtaining a biological sample from the patient; (b) subjecting the sample to an assay for detecting expression of one or more of ACSM2A, BDH2, C19orf51, C8orf76, CGB5, CSMD3, DAZ2, DUX4, FAM22G, FAM90A1, GABBR2, GRM3, HMMR, HOXC4, KAAG1, KRIT1, KRTAP20-1, LOC392196, LOC441956, LOC650293, LTB4R, METTL7B, NEK2, OR11H12, OR2J3, OR2L8, OR2M1P, OR2T3, OR4F5, OR52A4, OR5211, PGA3, PHACTR3, PMP2, PRAMEF6, PSG1, SIGLEC10, SOX11, SPDYE1, SSX1, TCEB3B, TCFL5, TFAP2D, TSPY2, UGT2B10, UGT2B11, UGT2B28, WDR49, and WFDC5; and (c) determining that the patient has prostate cancer or a likelihood thereof if the expression of the one or more biomarkers is increased relative to a reference non-prostate cancer sample.

    摘要翻译： 本发明涉及生物标志物领域。 更具体地，本发明提供了可用于诊断和/或预测前列腺癌的方法和组合物。 在具体实施方案中，用于诊断患者中的前列腺癌或其可能性的方法，包括以下步骤：（a）从患者获得生物样品; （b）对样品进行检测，以检测ACSM2A，BDH2，C19orf51，C8orf76，CGB5，CSMD3，DAZ2，DUX4，FAM22G，FAM90A1，GABBR2，GRM3，HMMR，HOXC4，KAAG1，KRIT1，KRTAP20中的一种或多种的表达 -1，LOC392196，LOC441956，LOC650293，LTB4R，METTL7B，NEK2，OR11H12，OR2J3，OR2L8，OR2M1P，OR2T3，OR4F5，OR52A4，OR5211，PGA3，PHACTR3，PMP2，PRAMEF6，PSG1，SIGLEC10，SOX11，SPDYE1，SSX1，TCEB3B ，TCFL5，TFAP2D，TSPY2，UGT2B10，UGT2B11，UGT2B28，WDR49和WFDC5; 如果一个或多个生物标志物的表达相对于参照非前列腺癌样品增加，则确定患者具有前列腺癌或其可能性。

    SYSTEMS AND METHODS RELATED TO COLLECTION OF BIOLOGICAL FLUIDS
    13.
    发明申请
    SYSTEMS AND METHODS RELATED TO COLLECTION OF BIOLOGICAL FLUIDS 有权
    与生物流体收集相关的系统和方法

    公开(公告)号：US20150223785A1

    公开(公告)日：2015-08-13

    申请号：US14692945

    申请日：2015-04-22

    申请人： Steven A. SHUBIN, SR.

    发明人： Steven A. SHUBIN, SR. ,  Steven A. SHUBIN, JR.

    IPC分类号： A61B10/00

    CPC分类号： A61B10/0058 ,  A61F5/453 ,  A61H19/32 ,  A61H2201/0153 ,  A61H2201/1253 ,  A61H2201/1409 ,  B29C45/2602 ,  B29L2023/001 ,  B29L2031/753

    摘要： Collection of biological fluids. At least some of the example embodiments are polymeric sleeves including: an elongate body that defines a first end, a second end opposite the first end, and a longitudinal central axis; a main passageway through the elongate body along the central axis, the main passageway extends from the first end to the second end, and the main passageway having a first aperture on the first end and a second aperture on the second end; a first member suspended over the first aperture on the first end, the first member having a first initial passageway substantially aligned with the main passageway; and a first plurality of stanchion portions that extend between the first member and the first end.

    摘要翻译： 收集生物体液。 示例性实施例中的至少一些是聚合物套筒，包括：细长体，其限定第一端，与第一端相对的第二端和纵向中心轴线; 主通道沿着中心轴线穿过细长体，主通道从第一端延伸到第二端，主通道在第一端具有第一孔，在第二端具有第二孔; 第一构件，其悬挂在第一端上的第一孔上，第一构件具有与主通道大致对准的第一初始通道; 以及在所述第一构件和所述第一端之间延伸的第一多个支柱部分。

    SYSTEMS AND METHODS RELATED TO COLLECTION OF BIOLOGICAL FLUIDS
    14.
    发明申请
    SYSTEMS AND METHODS RELATED TO COLLECTION OF BIOLOGICAL FLUIDS 有权
    与生物流体收集相关的系统和方法

    公开(公告)号：US20150202809A1

    公开(公告)日：2015-07-23

    申请号：US14676315

    申请日：2015-04-01

    申请人： Steven A. SHUBIN, Sr.

    发明人： Steven A. SHUBIN, Sr. ,  Steven A. SHUBIN, Jr.

    IPC分类号： B29C45/26 ,  A61H19/00 ,  A61B10/00

    CPC分类号： A61B10/0058 ,  A61F5/453 ,  A61H19/32 ,  A61H2201/0153 ,  A61H2201/1253 ,  A61H2201/1409 ,  B29C45/2602 ,  B29L2023/001 ,  B29L2031/753

    摘要： Collection of biological fluids. At least some of the example embodiments are methods including: placing a lower mold component, the lower mold component structurally defines a negative image of an insertion end of a polymeric sleeve; stacking into mating relationship a first disk member, the first disk member structural defines a negative image of an anterior volume vented to atmosphere on the insertion end of the polymeric sleeve; coupling a rod member to the disk member, an exterior surface of the rod member defines a negative image of a main passageway through the polymeric sleeve; closing an outer mold assembly around the rod member, an interior surface of the outer mold assembly structurally defines a negative image of an outer surface of the polymeric sleeve; and injecting a polymeric compound in a liquid state into the outer mold assembly.

    摘要翻译： 收集生物体液。 示例性实施例中的至少一些是方法，包括：放置下模具部件，下模具部件在结构上限定聚合物套筒的插入端的负像; 将第一盘构件堆叠成配合关系，第一盘构件结构限定在聚合物套筒的插入端上排出到大气的前体积的负像; 将杆构件联接到盘构件，杆构件的外表面限定通过聚合物套筒的主通道的负像; 关闭围绕杆构件的外模组件，外模组件的内表面结构地限定聚合物套筒的外表面的负像; 以及将液态的聚合物注射到所述外模组件中。

    SPERM COLLECTOR WITH SQUEEZING FUNCTION
    15.
    发明申请
    SPERM COLLECTOR WITH SQUEEZING FUNCTION 有权
    带收缩功能的SPERM收集器

    公开(公告)号：US20130253458A1

    公开(公告)日：2013-09-26

    申请号：US13892281

    申请日：2013-05-12

    申请人： Wei Wu

    发明人： Wei Wu

    IPC分类号： A61F5/453

    CPC分类号： A61F5/453 ,  A61B10/0058 ,  A61F5/41 ,  A61H19/32 ,  A61H2201/0228 ,  A61H2201/105 ,  A61H2201/5082

    摘要： A sperm collector is provided. The sperm collector includes an insert having a penis insertion passage. The sperm collector also includes a container having an outer shell forming an inside chamber. The outer shell has at least one opening. The inside chamber is configured to accommodate the insert. The sperm collector also includes a top end cover capable of being engaged with the container. The sperm collector further includes an elastic pressing unit disposed on the outer shell and coupled to the insert through the opening on the outer shell. The elastic pressing unit is configured to transmit pressure to the insert through the opening on the outer shell.

    摘要翻译： 提供精子收集器。 精子收集器包括具有阴茎插入通道的插入物。 精子收集器还包括具有形成内室的外壳的容器。 外壳具有至少一个开口。 内室被构造成容纳插入件。 精子收集器还包括能够与容器接合的顶端盖。 精子收集器还包括设置在外壳上并通过外壳上的开口连接到插入件的弹性按压单元。 弹性按压单元构造成通过外壳上的开口将压力传递到插入件。

    Artificial insemination
    16.
    发明授权
    Artificial insemination 有权
    人工授精

    公开(公告)号：US08192347B2

    公开(公告)日：2012-06-05

    申请号：US13039568

    申请日：2011-03-03

    申请人： Stephen August Bollinger

    发明人： Stephen August Bollinger

    IPC分类号： A61D7/00

    CPC分类号： A61B17/43 ,  A61B10/0058

    摘要： An artificial insemination device may include a condom having a sheath and a reinforced cup that caps one end of the sheath, thereby having an inner concave surface and an outer convex surface; and a delivery handle comprising an elongate extension sized, shaped, shaped to contact the outer convex surface of the condom cup.

    摘要翻译： 人造授精装置可以包括具有鞘和加强杯的避孕套，所述加强杯覆盖护套的一端，从而具有内凹表面和外凸表面; 以及递送手柄，其包括细长的延伸部，其大小，成形形状以接触避孕套杯的外凸面。

    SPERM SEPARATION SYSTEM
    17.
    发明申请
    SPERM SEPARATION SYSTEM 失效
    SPERM分离系统

    公开(公告)号：US20120052485A1

    公开(公告)日：2012-03-01

    申请号：US13265115

    申请日：2010-04-22

    申请人： Vered Shany ,  Isaac Tavori

    发明人： Vered Shany ,  Isaac Tavori

    IPC分类号： C12Q1/70 ,  C12Q1/02 ,  C12N5/076 ,  C12Q1/06 ,  C12M1/00 ,  C12M1/34

    CPC分类号： A01N1/0263 ,  A61B10/0058 ,  A61B10/0096 ,  A61B17/43 ,  A61D19/00 ,  C12N5/0612 ,  Y10T436/25

    摘要： The present invention provides a naturally based Sperm Separation System (SSS) for separation of at least a portion of sperm cell populations (SCP) within an original semen sample, such that an enπched SCP sample is obtained, comprising a a sperm separation device, comprising ι) a first chamber adapted to contain at least a portion of said original semen sample, said first chamber is characterized by predetermined 3D shape and volume, V, said first chamber is bounded by a rim such that said original sample is kept below said rim, n) a second chamber in physical communication with said first chamber and said nm, said second chamber is characterized by predetermined 3D shape and volume, V1, said second chamber is adapted to reside said enriched SCP sample, b incubation means, adapted to socket at least one of said cell separation device and to homogeneously thermoregulate the temperature within the same

    摘要翻译： 本发明提供了一种用于分离原始精液样品中至少一部分精子细胞群（SCP）的天然精子分离系统（SSS），从而获得了包含精子分离装置的精子分离装置， 包括ι）适于容纳所述原始精液样本的至少一部分的第一室，所述第一室的特征在于预定的3D形状和体积，V，所述第一室由边缘限定，使得所述原始样品保持在所述 边缘，n）与所述第一室和所述nm物理连通的第二室，所述第二室的特征在于预定的3D形状和体积V1，所述第二室适于驻留所述富集的SCP样品，b温育装置，适于 插入所述细胞分离装置中的至少一个并且均匀地调节其内的温度

    Biological Fluid Receptacle
    18.
    发明申请
    Biological Fluid Receptacle 审中-公开
    生物流体插座

    公开(公告)号：US20110270127A1

    公开(公告)日：2011-11-03

    申请号：US12311049

    申请日：2007-09-18

    申请人： Shany Vered ,  Isaac Tavori

    发明人： Shany Vered ,  Isaac Tavori

    IPC分类号： A61B5/00

    CPC分类号： A61B10/0096 ,  A61B10/0058 ,  A61B2010/0074

    摘要： There is provided a biological fluid receptacle that includes an outer surface adapted to be affixed to a carrier and a receptacle cavity adapted to receive and retain biological fluids.

    摘要翻译： 提供了生物流体容器，其包括适于固定到载体的外表面和适于接收和保留生物流体的容腔。