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公开(公告)号：US07807653B2
公开(公告)日：2010-10-05
申请号：US11818666
申请日：2007-06-14
申请人： Phillip D. Cook , Guangyi Wang , Thomas W. Bruice , Nicholas A. Boyle , Janet M. Leeds , Jennifer L. Brooks , Marija Prhavc , Maria Eugenia Ariza , Patrick C. Fagan , Yi Jin , Vivek K. Rajwanshi , Kathleen D. Tucker
发明人： Phillip D. Cook , Guangyi Wang , Thomas W. Bruice , Nicholas A. Boyle , Janet M. Leeds , Jennifer L. Brooks , Marija Prhavc , Maria Eugenia Ariza , Patrick C. Fagan , Yi Jin , Vivek K. Rajwanshi , Kathleen D. Tucker
IPC分类号： A61K31/7076 , A61K31/708 , C07H19/20
摘要： The present invention relates to nucleoside diphosphate mimics and nucleoside triphosphate mimics, which contain diphosphate or triphosphate moiety mimics and optionally sugar-modifications and/or base-modifications. The nucleotide mimics of the present invention, in a form of a pharmaceutically acceptable salt, a pharmaceutically acceptable prodrug, or a pharmaceutical formulation, are useful as antiviral, antimicrobial, and anticancer agents. The present invention provides a method for the treatment of viral infections, microbial infections, and proliferative disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of the present invention optionally in combination with other pharmaceutically active agents.
摘要翻译： 本发明涉及核苷二磷酸模拟物和核苷三磷酸模拟物，其含有二磷酸酯或三磷酸酯部分模拟物和任选的糖修饰和/或碱基修饰。 本发明的核苷酸模拟物以药学上可接受的盐，药学上可接受的前药或药物制剂的形式可用作抗病毒，抗微生物剂和抗癌剂。 本发明提供了一种治疗病毒感染，微生物感染和增殖性疾病的方法。 本发明还涉及包含任选与其它药物活性剂组合的本发明化合物的药物组合物。
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公开(公告)号：US07268119B2
公开(公告)日：2007-09-11
申请号：US11674954
申请日：2007-02-14
申请人： Phillip Dan Cook , Deborah K. Ewing, legal representative , Yi Jin , John Lambert , Marija Prhavc , Vasanthankumar Rajappan , Vivek K. Rajwanshi , Kandasamy Sakthivel
IPC分类号： A61K31/7052 , C07H19/23 , C07H19/044
摘要： Nucleosides and nucleotides containing a tricyclic base portion thereof are useful for treating infectious diseases and proliferative disorders, such as viral infections or cancer respectively.
摘要翻译： 含有三环碱基的核苷和核苷酸分别用于治疗感染性疾病和增殖性疾病，例如病毒感染或癌症。
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公开(公告)号：US07230114B2
公开(公告)日：2007-06-12
申请号：US10488791
申请日：2002-08-30
申请人： Brian David Judkins , Simon John Fawcett MacDonald , Derek Anthony Demaine , Graham George Adam Inglis , Julie Nicole Hamblin
发明人： Brian David Judkins , Simon John Fawcett MacDonald , Derek Anthony Demaine , Graham George Adam Inglis , Julie Nicole Hamblin
IPC分类号： C07D233/00
CPC分类号： C07D407/06 , C07D309/28 , Y02P20/55
摘要： Compounds of formula (I), methods for their preparation and their use in the manufacture of neuraminidase inhibitor conjugates. Wherein R represents as carboxylic acid protecting group; P1 and P2 can be the same or different and are selected from amine protecting groups; P3 represents a protecting group for 1, 2 diols; and LG represents a leaving group
摘要翻译： 式（I）的化合物，其制备方法及其在制备神经氨酸酶抑制剂缀合物中的用途。 其中R表示羧酸保护基; P 1和P 2可以相同或不同，并且选自胺保护基; P 3表示1,2二醇的保护基; LG代表离职团体
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14.发明授权Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of .alpha.-D-neuraninic acid 失效α-D-神经氨酸的抗病毒4-取代-2-脱氧-2,3-二脱氢衍生物
公开(公告)号：US5639786A
公开(公告)日：1997-06-17
申请号：US267309
申请日：1994-06-29
IPC分类号： C07D309/28 , A61K31/35
CPC分类号： C07D309/28
摘要： N-Acetylneuraminic and derivatives of formula (I) ##STR1## pharmaceutical formulations thereof, their use in medicine, in particular as antiviral agents and methods for their preparation are described.
摘要翻译： 描述了N-乙酰神经氨酸和式（I）的衍生物，其描述了它们在药物中的用途，特别是抗病毒剂及其制备方法。
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公开(公告)号：US5597933A
公开(公告)日：1997-01-28
申请号：US549820
申请日：1996-03-08
IPC分类号： B01J23/44 , B01J23/62 , C07B61/00 , C07D309/28
CPC分类号： C07D309/28 , Y02P20/55
摘要： The invention provides a method for the preparation of the compound of formula(I) ##STR1## which comprises catalytic hydrogenolysis of a compound of formula (II) ##STR2## (wherein R is H or a C.sub.1-4 alkyl group and R.sup.1 is H or a hydroxyl protecting group for example an acyl group such as acetyl) in aqueous formic acid followed, where necessary, by hydrolysis.
摘要翻译： PCT No.PCT / EP94 / 01940 Sec。 371日期：1996年3月8日 102（e）1996年3月8日PCT 1994年6月15日PCT公布。 公开号WO95 / 00503 日期1 9 9 5年1月5日本发明提供了制备式（I）化合物的方法，其包括式（II）化合物（II）的催化氢解（其中R为H 或C 1-4烷基，R 1为H或羟基保护基，例如酰基如乙酰基）在甲酸水溶液中，然后根据需要通过水解。
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![Substituted imidazo[1,2-a]imidazo[4′,5′:4,5]pyrrolo[1,2-d]pyrazines for treating respiratory syncytial virus infections](/abs-image/US/2016/06/07/US09359377B2/abs.jpg.150x150.jpg)
16.发明授权Substituted imidazo[1,2-a]imidazo[4′,5′:4,5]pyrrolo[1,2-d]pyrazines for treating respiratory syncytial virus infections 有权取代咪唑并[1,2-a]咪唑并[4'，5'：4,5]吡咯并[1,2-d]吡嗪用于治疗呼吸道合胞病毒感染公开(公告)号：US09359377B2
公开(公告)日：2016-06-07
申请号：US14142666
申请日：2013-12-27
IPC分类号： A61K31/4985 , C07D241/36 , C07D495/22 , C07D487/14 , C07D471/22 , C07D487/22 , C07D491/22 , C07D513/22
CPC分类号： C07D495/22 , A61K31/4985 , C07D471/22 , C07D487/14 , C07D487/22 , C07D491/22 , C07D513/22
摘要： The present invention relates to compounds of formula (I) or salts, racemates, isomers and/or prodrugs thereof useful in the treatment of viral infections, in particular respiratory syncytial viral (RSV) infections. The present invention also relates to processes for preparing the compounds and intermediates used in their preparation.
摘要翻译： 本发明涉及用于治疗病毒感染，特别是呼吸道合胞病毒（RSV）感染的式（I）化合物或其盐，外消旋体，异构体和/或前药。 本发明还涉及制备用于其制备的化合物和中间体的方法。
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![Substituted imidazo[1,2-a]pyrrolo[1,2-d]pyrazines for treating respiratory syncytial virus infections](/abs-image/US/2015/10/20/US09163029B2/abs.jpg.150x150.jpg)
17.发明授权Substituted imidazo[1,2-a]pyrrolo[1,2-d]pyrazines for treating respiratory syncytial virus infections 有权用于治疗呼吸道合胞病毒感染的取代的咪唑并[1,2-a]吡咯并[1,2-d]吡嗪公开(公告)号：US09163029B2
公开(公告)日：2015-10-20
申请号：US14061616
申请日：2013-10-23
发明人： Jeffrey Peter Mitchell , Gary Pitt , Alistair George Draffan , Penelope Anne Mayes , Laura Andrau , Kelly Helen Anderson
IPC分类号： C07D487/14 , A61K31/407 , A61K31/4162 , A61K31/4188 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D207/333 , C07D213/79
CPC分类号： C07D487/14 , A61K31/407 , A61K31/4162 , A61K31/4188 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D207/333 , C07D207/34 , C07D213/79 , C07D405/12
摘要： The present invention relates to compounds of formula (I) its salts, isomers or prodrugs thereof useful in the treatment of viral infections, in particular respiratory syncytial virus (RSV) infections. The present invention also relates to processes for preparing the compounds and intermediates used in their preparation.
摘要翻译： 本发明涉及其用于治疗病毒感染，特别是呼吸道合胞病毒（RSV）感染的其盐，异构体或前药的式（I）化合物。 本发明还涉及制备用于其制备的化合物和中间体的方法。
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公开(公告)号：US20140179709A1
公开(公告)日：2014-06-26
申请号：US14136106
申请日：2013-12-20
IPC分类号： C07D417/14 , C07D413/14 , C07D413/12 , C07D401/14
CPC分类号： C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
摘要： This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula I.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的衍生物，包含这些化合物的药物组合物及其在哺乳动物中治疗微小RNA病毒感染的用途，以及可用于制备式I化合物的新型中间体。
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19.发明申请Polycyclic Agents for the Treatment of Respiratory Syncytial Virus Infections 审中-公开用于治疗呼吸道合胞病毒感染的多环药公开(公告)号：US20140051689A1
公开(公告)日：2014-02-20
申请号：US14062780
申请日：2013-10-24
发明人： Silas Bond , Vanessa Anne Sanford , John Nicholas Lambert , Chin Yu Lim , Alistair George Draffan , Roland Henry Nearn , Jeffrey Peter Mitchell
IPC分类号： C07D487/04 , C07D487/14 , C07D519/00 , C07D471/14
CPC分类号： C07D487/04 , A61K31/4188 , A61K31/424 , A61K31/4353 , C07D471/14 , C07D487/14 , C07D519/00
摘要： Compounds of formula (I), and their use as in the treatment of infections involving viruses of the Pneumovirinae sub-family (RSV) are disclosed. In the formula ring (A) may be phenyl, pyridyl etc., (B-C) may be CH2—CH2 etc., (R1) may be phenyl and substituted forms thereof, (R2) may be assorted substituents.
摘要翻译： 公开了式（I）化合物及其在治疗涉及肺炎链球菌属亚型（RSV）病毒的感染中的用途。 在式中，环（A）可以是苯基，吡啶基等，（B-C）可以是CH 2 -CH 2等，（R 1）可以是苯基及其取代形式，（R2）可以是各种取代基。
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20.发明授权公开(公告)号：US08598194B2
公开(公告)日：2013-12-03
申请号：US12443177
申请日：2007-09-26
申请人： Jeffrey Peter Mitchell , Alistair George Draffan , Vanessa Anne Sanford , Silas Bond , Chin Yu Lim , Penelope Anne Mayes
发明人： Jeffrey Peter Mitchell , Alistair George Draffan , Vanessa Anne Sanford , Silas Bond , Chin Yu Lim , Penelope Anne Mayes
CPC分类号： A61K39/42 , A61K31/437 , A61K31/4375 , A61K31/501 , A61K31/7056 , C07D471/04 , C07D471/14
摘要： The present invention relates to polycyclic antiviral compounds, and salts thereof, methods for their preparation and compositions containing them, and the use of the compounds and composition in the treatment of viral infections.
摘要翻译： 本发明涉及多环抗病毒化合物及其盐，其制备方法和含有它们的组合物，以及该化合物和组合物在治疗病毒感染中的用途。
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