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11.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF CYSTEINYL-TRNA SYNTHETASE 有权与CYSTEINYL-TRNA SYNTHETASE蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US20150284704A1
公开(公告)日：2015-10-08
申请号：US14616015
申请日：2015-02-06
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C12N9/00 , G01N33/573
CPC分类号： C07K16/40 , A61K38/00 , A61K39/39591 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C12N9/93 , C12Y601/01016 , G01N33/573 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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12.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF ISOLEUCYL TRNA SYNTHETASES 有权治疗，诊断和抗体组合物的创新发现与蛋白质TRAAS合成蛋白片段相关公开(公告)号：US20150240228A1
公开(公告)日：2015-08-27
申请号：US14593613
申请日：2015-01-09
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C12N9/00 , G01N33/573
CPC分类号： C07K16/40 , A61K38/00 , A61K39/39591 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/92 , C07K2319/00 , C12N9/93 , C12Y601/01 , C12Y601/01005 , G01N33/573 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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13.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF PHENYLALANYL-BETA-TRNA SYNTHETASES 有权治疗，诊断和抗体组合物与苯丙氨酸-ATNA-TRNA合成蛋白片段相关的创新发现公开(公告)号：US20150231214A1
公开(公告)日：2015-08-20
申请号：US14577510
申请日：2014-12-19
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , Zhiwen Xu , John D. Mendlein
IPC分类号： A61K38/53 , G01N33/573 , C12N9/00
CPC分类号： A61K38/53 , A61K38/00 , C07K16/40 , C07K2317/21 , C07K2317/55 , C12N5/0602 , C12N9/93 , C12N9/96 , C12Y601/0102 , G01N33/573 , G01N33/68 , G01N2333/9015 , G01N2500/00
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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14.发明授权Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases 有权用于治疗自身免疫性和炎性疾病的组氨酰-tRNA合成酶公开(公告)号：US08835387B2
公开(公告)日：2014-09-16
申请号：US13769100
申请日：2013-02-15
发明人： Kyle P. Chiang , Elisabeth Gardiner , Ching-Fun Lau , Wing-Sze Lo , Jeffrey Greve , Melissa Ashlock , John D. Mendlein
CPC分类号： C12N9/93 , A61K38/16 , A61K38/17 , A61K38/53 , A61K39/0008 , A61K48/00 , A61K48/005 , C12Q1/6883 , C12Q2600/158 , C12Y601/01021 , G01N33/573 , G01N2333/9015 , G01N2800/52 , Y02A50/473
摘要： The present invention relates generally to compositions and methods comprising histidyl-tRNA synthetase polypeptides or other specific blocking agents for the treatment autoimmune diseases and other inflammatory diseases, including those related to Jo-1 antibodies.
摘要翻译： 本发明一般涉及包含组氨酰-tRNA合成酶多肽或用于治疗自身免疫性疾病和其它炎性疾病的其它特异性阻断剂的组合物和方法，包括与Jo-1抗体相关的那些。
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15.发明申请公开(公告)号：US20200172632A1
公开(公告)日：2020-06-04
申请号：US16585805
申请日：2019-09-27
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C07K16/40 , C12N9/00 , G01N33/573 , A61K9/00
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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公开(公告)号：US10196628B2
公开(公告)日：2019-02-05
申请号：US15459875
申请日：2017-03-15
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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公开(公告)号：US10189911B2
公开(公告)日：2019-01-29
申请号：US15365104
申请日：2016-11-30
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C12N9/96 , A61K38/53 , C12N9/00 , A61K9/00 , A61K9/19 , C07K16/40 , C12N5/071 , G01N33/50 , G01N33/68 , G01N33/573
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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公开(公告)号：US20180008683A1
公开(公告)日：2018-01-11
申请号：US15599183
申请日：2017-05-18
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , Zhiwen Xu , John D. Mendlein
IPC分类号： A61K38/53 , C12N9/00 , G01N33/573
CPC分类号： A61K38/53 , A61K38/00 , C07K16/40 , C07K2317/21 , C07K2317/55 , C12N5/0602 , C12N9/93 , C12N9/96 , C12Y601/0102 , G01N33/573 , G01N33/68 , G01N2333/9015 , G01N2500/00
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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19.发明申请公开(公告)号：US20170321206A1
公开(公告)日：2017-11-09
申请号：US15459875
申请日：2017-03-15
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
CPC分类号： C12N9/93 , A61K38/00 , A61K38/53 , C07K16/40 , C12N5/0602 , C12N9/96 , C12Y601/01 , C12Y601/01021 , G01N33/68
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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20.发明申请公开(公告)号：US20170190792A1
公开(公告)日：2017-07-06
申请号：US15365104
申请日：2016-11-30
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
CPC分类号： C07K16/40 , A61K9/0019 , A61K9/19 , A61K38/53 , C07K2317/24 , C07K2317/34 , C07K2317/92 , C12N5/0602 , C12N9/93 , C12N9/96 , C12Y601/01 , C12Y601/01009 , G01N33/5011 , G01N33/573 , G01N33/68 , G01N2333/9015 , G01N2500/10
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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