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    Heart valve chordae replacement methods and apparatus
    11.
    发明申请
    Heart valve chordae replacement methods and apparatus 有权
    心脏瓣膜切除方法及装置

    公开(公告)号：US20080228223A1

    公开(公告)日：2008-09-18

    申请号：US12074586

    申请日：2008-03-04

    Applicant: Yousef F. Alkhatib

    Inventor： Yousef F. Alkhatib

    IPC: A61B17/08 ,  A61B17/10

    CPC classification number: A61F2/2427 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/08 ,  A61B2017/00247 ,  A61B2017/00867 ,  A61B2017/0417 ,  A61B2017/06052 ,  A61B2017/0649 ,  A61B2018/00392 ,  A61B2090/036 ,  A61F2/2442 ,  A61F2/2457

    Abstract: Apparatus for attaching a prosthetic tether between a leaflet of a patient's heart valve and another portion of the patient's heart to help prevent prolapse of the leaflet and/or to otherwise improve leaflet function. The apparatus can be used with relatively low invasiveness of the patient's body. The apparatus releasably clamps the leaflet during attachment of the tether to the leaflet. The apparatus may include an integrated display for indicating how extensively the leaflet is being clamped. The apparatus may include structure for stabilizing the leaflet for better clamping. The apparatus may enter the heart through an aperture in the wall of the heart, and may include structure for helping to reduce blood leakage from that aperture. The apparatus may be able to enter the heart by following a guide wire. The apparatus may include various means for attaching the tether to the leaflet.

    Abstract translation: 用于将患者心脏瓣膜的小叶与患者心脏的另一部分之间的假肢系绳连接以有助于防止小叶脱垂和/或另外改善小叶功能的装置。 该装置可以以相对低的患者身体的侵入性使用。 该装置在将系绳附接到小叶时可释放地夹紧小叶。 所述装置可以包括用于指示所述传单被广泛地夹紧的集成显示器。 该装置可以包括用于稳定小叶以更好地夹紧的结构。 该装置可以通过心脏壁中的孔进入心脏，并且可以包括用于帮助减少该孔的血液渗漏的结构。 该装置可能能够通过跟随导丝进入心脏。 该装置可以包括用于将系绳附接到传单的各种装置。

    Prosthetic heart valves
    12.
    发明授权
    Prosthetic heart valves 有权
    假心脏瓣膜

    公开(公告)号：US09572660B2

    公开(公告)日：2017-02-21

    申请号：US12451678

    申请日：2008-06-04

    Applicant: Peter N. Braido ,  Yousef F. Alkhatib

    Inventor： Peter N. Braido ,  Yousef F. Alkhatib

    IPC: A61F2/82 ,  A61F2/24 ,  A61L27/36 ,  A61L27/54

    CPC classification number: A61F2/2418 ,  A61F2210/0076 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/008 ,  A61L27/3604 ,  A61L27/54

    Abstract: A prosthetic heart valve (10) (e.g., a prosthetic aortic valve) is designed to be somewhat circumferentially collapsible and then re-expandable. The collapsed condition may be used for less invasive delivery of the valve into a patient. When the valve reaches the implant site in the patient, it re-expands to normal operating size, and also to engage surrounding tissue of the patient. The valve includes a stent portion (200) and a ring portion (100) that is substantially concentric with the stent portion but downstream from the stent portion in the direction of blood flow through the implanted valve. When the valve is implanted, the stent portion engages the patient's tissue at or near the native valve annulus, while the ring portion engages tissue downstream from the native valve site (e.g., the aorta).

    Abstract translation: 假体心脏瓣膜（10）（例如，假体主动脉瓣）被设计成有些周向可折叠并且然后再膨胀。 折叠状态可以用于将瓣膜侵入性较差的患者。 当阀门到达病人的植入部位时，它会重新扩大到正常的操作大小，并且还可以接合病人的周围组织。 所述阀包括支架部分（200）和环状部分（100），所述支架部分（100）与所述支架部分基本上同心，但在所述支架部分的下游沿着通过所述植入瓣膜的血流方向。 当植入瓣膜时，支架部分在天然瓣膜环处或附近接合患者组织，而环部分接合自然瓣膜部位（例如，主动脉）下游的组织。

    Collapsible/expandable prosthetic heart valves with native calcified leaflet retention features
    14.
    发明授权
    Collapsible/expandable prosthetic heart valves with native calcified leaflet retention features 有权
    具有天然钙化小叶保留特征的可折叠/可扩张的假体心脏瓣膜

    公开(公告)号：US08784481B2

    公开(公告)日：2014-07-22

    申请号：US12733763

    申请日：2008-09-26

    Applicant: Yousef F. Alkhatib ,  Michael J. Girard

    Inventor： Yousef F. Alkhatib ,  Michael J. Girard

    IPC: A61F2/24

    CPC classification number: A61F2/2409 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2230/0006 ,  A61F2230/0054 ,  A61F2230/0069 ,  A61F2230/0076

    Abstract: A prosthetic heart valve is circumferentially collapsible for less invasive delivery into a patient. The valve re-expands to operating size at the implant site in the patient. A frame structure of the valve includes restraining structure that can help to push one or more of the patient's native heart valve leaflets radially outwardly so that this native leaflet tissue does not interfere with the operation or service life of the prosthetic valve.

    Abstract translation: 假体心脏瓣膜是周向可折叠的，用于较少侵入性地输送到患者体内。 瓣膜在病人的植入部位重新扩大到操作尺寸。 阀的框架结构包括限制结构，其可以帮助推动病人的天然心脏瓣膜叶片中的一个或多个径向向外，使得该天然小叶组织不会干扰人工瓣膜的操作或使用寿命。

    Delivery and retrieval systems for collapsible/expandable prosthetic heart valves
    16.
    发明授权
    Delivery and retrieval systems for collapsible/expandable prosthetic heart valves 有权
    可折叠/可扩张假体心脏瓣膜的输送和检索系统

    公开(公告)号：US09180004B2

    公开(公告)日：2015-11-10

    申请号：US12735273

    申请日：2009-01-08

    Applicant: Yousef F. Alkhatib

    Inventor： Yousef F. Alkhatib

    IPC: A61F2/24 ,  A61F2/95

    CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/2439 ,  A61F2002/9511

    Abstract: A system for delivering a collapsible and re-expandable prosthetic heart valve into a patient includes a valve support structure (140) around which the valve (10) is disposed in a collapsed condition. A sheath structure (110) surrounds the collapsed valve, but can be moved relative to the valve to uncover it for expansion at the desired implant site in the patient. The sheath structure may be variously mounted and moved to deploy the valve in various ways. For example, the sheath structure may include multiple parts, each of which can be moved separately to separately deploy various parts of the valve. The apparatus may have other aspects, such as the ability to reverse deployment of the valve, the ability to pass other instrumentation through the valve delivery apparatus, the ability to be smoothly withdrawn from the patient after deployment of the valve, etc.

    Abstract translation: 用于将可折叠和可再膨胀的假体心脏瓣膜递送到患者中的系统包括阀支撑结构（140），阀（10）围绕该阀支撑结构设置在折叠状态。 护套结构（110）围绕塌缩的瓣膜，但是可以相对于瓣膜移动以露出，以便在患者的期望的植入部位处展开。 护套结构可以以各种方式进行各种安装和移动以展开阀。 例如，护套结构可以包括多个部件，每个部件可以单独移动以分开地部署阀的各个部件。 该装置可以具有其他方面，例如逆向部署阀的能力，通过其他仪器通过阀输送装置的能力，在部署阀之后能够平稳地从患者撤出的能力等。

    DELIVERY AND RETRIEVAL SYSTEMS FOR COLLAPSIBLE/EXPANDABLE PROSTHETIC HEART VALVES
    17.
    发明申请
    DELIVERY AND RETRIEVAL SYSTEMS FOR COLLAPSIBLE/EXPANDABLE PROSTHETIC HEART VALVES 有权
    可拆卸/可扩展的心脏瓣膜输送和检测系统

    公开(公告)号：US20100286768A1

    公开(公告)日：2010-11-11

    申请号：US12735273

    申请日：2009-01-08

    Applicant: Yousef F. Alkhatib

    Inventor： Yousef F. Alkhatib

    IPC: A61F2/24

    CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/2439 ,  A61F2002/9511

    Abstract: A system for delivering a collapsible and re-expandable prosthetic heart valve into a patient includes a valve support structure (140) around which the valve (10) is disposed in a collapsed condition. A sheath structure (110) surrounds the collapsed valve, but can be moved relative to the valve to uncover it for expansion at the desired implant site in the patient. The sheath structure may be variously mounted and moved to deploy the valve in various ways. For example, the sheath structure may include multiple parts, each of which can be moved separately to separately deploy various parts of the valve. The apparatus may have other aspects, such as the ability to reverse deployment of the valve, the ability to pass other instrumentation through the valve delivery apparatus, the ability to be smoothly withdrawn from the patient after deployment of the valve, etc.

    Abstract translation: 用于将可折叠和可再膨胀的假体心脏瓣膜递送到患者中的系统包括阀支撑结构（140），阀（10）围绕该阀支撑结构设置在折叠状态。 护套结构（110）围绕塌缩的瓣膜，但是可以相对于瓣膜移动以露出，以便在患者的期望的植入部位处展开。 护套结构可以以各种方式进行各种安装和移动以展开阀。 例如，护套结构可以包括多个部件，每个部件可以单独移动以分开地部署阀的各个部件。 该装置可以具有其他方面，例如逆向部署阀的能力，通过其他仪器通过阀输送装置的能力，在部署阀之后能够平稳地从患者撤出的能力等。

    PROSTHETIC HEART VALVES
    18.
    发明申请
    PROSTHETIC HEART VALVES 有权
    先天性心脏瓣膜

    公开(公告)号：US20100168839A1

    公开(公告)日：2010-07-01

    申请号：US12451678

    申请日：2008-06-04

    Applicant: Peter N. Braido ,  Yousef F. Alkhatib

    Inventor： Peter N. Braido ,  Yousef F. Alkhatib

    IPC: A61F2/82 ,  A61F2/24

    CPC classification number: A61F2/2418 ,  A61F2210/0076 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/008 ,  A61L27/3604 ,  A61L27/54

    Abstract: A prosthetic heart valve (10) (e.g., a prosthetic aortic valve) is designed to be somewhat circumferentially collapsible and then re-expandable. The collapsed condition may be used for less invasive delivery of the valve into a patient. When the valve reaches the implant site in the patient, it re-expands to normal operating size, and also to engage surrounding tissue of the patient. The valve includes a stent portion (200) and a ring portion (100) that is substantially concentric with the stent portion but downstream from the stent portion in the direction of blood flow through the implanted valve. When the valve is implanted, the stent portion engages the patient's tissue at or near the native valve annulus, while the ring portion engages tissue downstream from the native valve site (e.g., the aorta).

    Abstract translation: 假体心脏瓣膜（10）（例如，假体主动脉瓣）被设计成有些周向可折叠并且然后再膨胀。 折叠状态可以用于将瓣膜侵入性较差的患者。 当阀门到达病人的植入部位时，它会重新扩大到正常的操作大小，并且还可以接合病人的周围组织。 所述阀包括支架部分（200）和环状部分（100），所述支架部分（100）与所述支架部分基本上同心，但在所述支架部分的下游沿着通过所述植入瓣膜的血流方向。 当植入瓣膜时，支架部分在天然瓣膜环处或附近接合患者组织，而环部分接合自然瓣膜部位（例如，主动脉）下游的组织。

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