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![Solid forms of (R)-1(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide](/abs-image/US/2023/02/14/US11578062B2/abs.jpg.150x150.jpg)
公开(公告)号：US11578062B2
公开(公告)日：2023-02-14
申请号：US17104903
申请日：2020-11-25
发明人： Ali Keshavarz-Shokri , Beili Zhang , Tim Edward Alcacio , Elaine Chungmin Lee , Yuegang Zhang , Mariusz Krawiec
IPC分类号： C07D405/12 , A61K31/404 , A61K31/47 , A61K31/4709 , A61K45/06
摘要： The present invention relates to solid forms of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1) in substantially crystalline form (Form A) or amorphous form, pharmaceutical compositions thereof, and methods of treatment therewith.
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![Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide](/abs-image/US/2018/09/25/US10081621B2/abs.jpg.150x150.jpg)
公开(公告)号：US10081621B2
公开(公告)日：2018-09-25
申请号：US14676205
申请日：2015-04-01
发明人： Ali Keshavarz-Shokri , Beili Zhang , Tim Edward Alcacio , Elaine Chungmin Lee , Yuegang Zhang , Mariusz Krawiec
IPC分类号： C07D405/12 , A61K31/404 , A61K45/06 , A61K31/47 , A61K31/4709
CPC分类号： C07D405/12 , A61K31/404 , A61K31/47 , A61K31/4709 , A61K45/06 , C07B2200/13 , A61K2300/00
摘要： The present invention relates to solid forms of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1) in substantially crystalline form (Form A) or amorphous form, pharmaceutical compositions thereof, and methods of treatment therewith.
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![SOLID FORMS OF 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL)CYCLOPROPANECARBOXAMIDO)-3-METHYLPYRIDIN-2-YL) BENZOIC ACID](/abs-image/US/2018/05/10/US20180127398A1/abs.jpg.150x150.jpg)
13.发明申请公开(公告)号：US20180127398A1
公开(公告)日：2018-05-10
申请号：US15807663
申请日：2017-11-09
IPC分类号： C07D405/12 , A61K31/4709
CPC分类号： C07D405/12 , A61K31/4709 , C07B2200/13
摘要： The present invention relates to a substantially crystalline and free solid state form of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methypyridin-2-yl)benzoic acid (Form I), pharmaceutical compositions thereof, and methods of treatment therewith.
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![Solid forms of N[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide](/abs-image/US/2018/04/03/US09931334B2/abs.jpg.150x150.jpg)
14.发明授权公开(公告)号：US09931334B2
公开(公告)日：2018-04-03
申请号：US15584324
申请日：2017-05-02
发明人： Patricia Hurter , William Rowe , Christopher R. Young , Adriana Costache , Patrick R. Connelly , Mariusz Krawiec , Yuchuan Gong , Yushi Feng , Martin Trudeau
IPC分类号： A61K31/47
CPC分类号： A61K31/47 , A61K2300/00 , C07B2200/13 , C07D215/56 , Y10T428/2982
摘要： The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
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![Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid](/abs-image/US/2017/12/12/US09840499B2/abs.jpg.150x150.jpg)
公开(公告)号：US09840499B2
公开(公告)日：2017-12-12
申请号：US15097252
申请日：2016-04-12
IPC分类号： A61K31/4709 , C07D405/12
CPC分类号： C07D405/12 , A61K31/4709 , C07B2200/13
摘要： The present invention relates to a substantially crystalline and free solid state form of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Form I), pharmaceutical compositions thereof, and methods of treatment therewith.
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![Solid Forms of (R)-1(2,2-Difluorobenzo[D][1,3]Dioxol-5-yl)-N-(1-(2,3-Dihydroxypropyl-6-Fluoro-2-(1-Hydroxy-2-Methylpropan-2-yl)-1H-lndol-5-yl)-Cyclopropanecarboxamide](/abs-image/US/2015/01/01/US20150005344A1/abs.jpg.150x150.jpg)
16.发明申请Solid Forms of (R)-1(2,2-Difluorobenzo[D][1,3]Dioxol-5-yl)-N-(1-(2,3-Dihydroxypropyl-6-Fluoro-2-(1-Hydroxy-2-Methylpropan-2-yl)-1H-lndol-5-yl)-Cyclopropanecarboxamide 有权（R）-1（2,2-二氟苯并[D] [1,3]二氧杂环戊烯-5-基）-N-（1-（2,3-二羟基丙基）-6-氟-2-（1- 羟基-2-甲基丙-2-基）-1H-吲哚-5-基） - 环丙烷甲酰胺公开(公告)号：US20150005344A1
公开(公告)日：2015-01-01
申请号：US14318131
申请日：2014-06-27
发明人： Ali Keshavarz-Shokri , Beili Zhang , Tim Edward Alcacio , Elaine Chungmin Lee , Yuegang Zhang , Mariusz Krawiec
IPC分类号： C07D405/12 , A61K45/06 , A61K31/47 , A61K31/404
CPC分类号： C07D405/12 , A61K31/404 , A61K31/47 , A61K31/4709 , A61K45/06 , C07B2200/13 , A61K2300/00
摘要： The present invention relates to solid forms of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1) in substantially crystalline form (Form A) or amorphous form, pharmaceutical compositions thereof, and methods of treatment therewith.
摘要翻译： 本发明涉及（R）-1-（2,2-二氟苯并[d] [1,3]间二氧杂环戊烯-5-基）-N-（1-（2,3-二羟丙基）-6- （A型）或无定形形式的2-氟-2-（1-羟基-2-甲基丙-2-基）-1H-吲哚-5-基）环丙烷甲酰胺（化合物1）及其药物组合物，以及 治疗。
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![SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE](/abs-image/US/2014/11/06/US20140329855A1/abs.jpg.150x150.jpg)
17.发明申请SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 审中-公开N- [2,4-BIS（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-羧酰胺的固体形式公开(公告)号：US20140329855A1
公开(公告)日：2014-11-06
申请号：US14334902
申请日：2014-07-18
发明人： Sneha G. Arekar , Steven C. Johnston , Mariusz Krawiec , Ales Medek , Praveen Mudunuri , Mark Jeffrey Sullivan
IPC分类号： C07D215/56
CPC分类号： C07D215/56
摘要： The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
摘要翻译： 本发明涉及N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺（化合物1）的固体形式，药物组合物 及其方法。
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![Solid Forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide](/abs-image/US/2014/08/28/US20140242172A1/abs.jpg.150x150.jpg)
18.发明申请Solid Forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide 有权固体形式的N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺公开(公告)号：US20140242172A1
公开(公告)日：2014-08-28
申请号：US14272692
申请日：2014-05-08
发明人： Patricia Hurter , William Rowe , Christopher R. Young , Adriana Costache , Patrick R. Connelly , Mariusz Krawiec , Yuchuan Gong , Yushi Feng , Martin Trudeau
IPC分类号： C07D215/56 , A61K31/47
CPC分类号： A61K31/47 , A61K2300/00 , C07B2200/13 , C07D215/56 , Y10T428/2982
摘要： The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
摘要翻译： 本发明涉及N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺（化合物1）的固体形式，药物组合物 及其方法。
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![Solid Forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide](/abs-image/US/2013/01/17/US20130018071A1/abs.jpg.150x150.jpg)
19.发明申请公开(公告)号：US20130018071A1
公开(公告)日：2013-01-17
申请号：US13622598
申请日：2012-09-19
发明人： Sneha G. Arekar , Steven C. Johnston , Mariusz Krawiec , Ales Medek , Praveen Mudunuri , Mark Jeffrey Sullivan
IPC分类号： C07D215/56 , A61P11/06 , A61P11/00 , A61P29/00 , A61P1/00 , A61P1/16 , A61P1/10 , A61P3/00 , A61P3/06 , A61P3/10 , A61P7/12 , A61P27/02 , A61P19/10 , A61P19/08 , A61P25/00 , A61P25/28 , A61P25/16 , A61P25/14 , A61K31/47
CPC分类号： C07D215/56
摘要： The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
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![SOLID FORMS OF (R)-1(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL)-N-(1-(2,3-DIHYDROXYPROPYL)-6-FLUORO-2-(1-HYDROXY-2-METHYLPROPAN-2-YL)-1H-INDOL-5-YL)CYCLOPROPANECARBOXAMIDE](/abs-image/US/2023/10/19/US20230331712A1/abs.jpg.150x150.jpg)
公开(公告)号：US20230331712A1
公开(公告)日：2023-10-19
申请号：US17992294
申请日：2022-11-22
发明人： Ali Keshavarz-Shokri , Beili Zhang , Tim Edward Alcacio , Elaine Chungmin Lee , Yuegang Zhang , Mariusz Krawiec
IPC分类号： C07D405/12 , A61K31/404 , A61K45/06 , A61K31/47 , A61K31/4709
CPC分类号： C07D405/12 , A61K31/404 , A61K45/06 , A61K31/47 , A61K31/4709 , C07B2200/13
摘要： The present invention relates to solid forms of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1) in substantially crystalline form (Form A) or amorphous form, pharmaceutical compositions thereof, and methods of treatment therewith.
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