![SOLID FORMS OF (R)-1(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL)-N-(1-(2,3-DIHYDROXYPROPYL)-6-FLUORO-2-(1-HYDROXY-2-METHYLPROPAN-2-YL)-1H-INDOL-5-YL)CYCLOPROPANECARBOXAMIDE](/docs/US/2023-10-19/US20230331712A1/abs.jpg.600x600.jpg)
- 专利标题： SOLID FORMS OF (R)-1(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL)-N-(1-(2,3-DIHYDROXYPROPYL)-6-FLUORO-2-(1-HYDROXY-2-METHYLPROPAN-2-YL)-1H-INDOL-5-YL)CYCLOPROPANECARBOXAMIDE
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申请号： US17992294申请日： 2022-11-22
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公开(公告)号： US20230331712A1公开(公告)日： 2023-10-19
- 发明人: Ali Keshavarz-Shokri , Beili Zhang , Tim Edward Alcacio , Elaine Chungmin Lee , Yuegang Zhang , Mariusz Krawiec
- 申请人： Vertex Pharmaceuticals Incorporated
- 申请人地址： US MA Boston
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： US MA Boston
- 分案原申请号： US14676205 2015.04.01
- 主分类号： C07D405/12
- IPC分类号： C07D405/12 ; A61K31/404 ; A61K45/06 ; A61K31/47 ; A61K31/4709
![SOLID FORMS OF (R)-1(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL)-N-(1-(2,3-DIHYDROXYPROPYL)-6-FLUORO-2-(1-HYDROXY-2-METHYLPROPAN-2-YL)-1H-INDOL-5-YL)CYCLOPROPANECARBOXAMIDE](/abs-image/US/2023/10/19/US20230331712A1/abs.jpg.150x150.jpg)
摘要：
The present invention relates to solid forms of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1) in substantially crystalline form (Form A) or amorphous form, pharmaceutical compositions thereof, and methods of treatment therewith.
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