公开(公告)号：US20120082732A1

公开(公告)日：2012-04-05

申请号：US13313664

申请日：2011-12-07

Applicant: JENS FEHRE ,  Ralf Nanke ,  Martin Stetter

Inventor： JENS FEHRE ,  Ralf Nanke ,  Martin Stetter

IPC: A61K38/17 ,  A61K9/14 ,  A61K31/7088 ,  A61P37/04 ,  A61K35/76 ,  A61K39/395 ,  A61P35/00

CPC classification number: A61K9/1676 ,  A61K9/0009

Abstract: In a method for treating a carcinoma in a patient, a medicine is administered via the blood stream of the patient that appears, to the patient's immune system, that tissue of the carcinoma is an inflammation source. The medicine employs two active components that are coupled to each other in a form allowing administration of the two active components to the carcinoma via the blood stream of the patient. A first of the active components is at least one coupling molecule that specifically tethers to a target molecule formed by cancer tissue of the carcinoma. A second of the active ingredients is at least one signal molecule typical to inflammation, or at least one originating molecule encoding such a signal molecule, that induces the immune system of the body to attack the cancer cells.

Abstract translation: 在用于治疗患者癌症的方法中，药物通过出现在患者的免疫系统中的患者的血流中被施用，癌的组织是炎症源。 药物使用两种活性组分，其以允许经由患者的血液将两种活性成分施用于癌的形式彼此偶联。 活性组分中的第一个是至少一个特异性地连接到由癌的癌组织形成的靶分子的偶联分子。 活性成分中的第二种是至少一种典型的炎症信号分子，或至少一种编码这种信号分子的起始分子，其诱导身体的免疫系统侵袭癌细胞。

公开(公告)号：US20090180586A1

公开(公告)日：2009-07-16

申请号：US11943786

申请日：2007-11-21

Applicant: Jens Fehre ,  Ralf Nanke ,  Monika Schwarz

Inventor： Jens Fehre ,  Ralf Nanke ,  Monika Schwarz

IPC: H05G1/60 ,  A61B6/04

CPC classification number: A61B6/4429 ,  A61B6/587

Abstract: A urological x-ray workstation has an x-ray source and an x-ray receiver that are respectively supported on device retainers of a device carrier located at the longitudinal side of a patient positioning table such that they can be positioned opposite one another and independently of one another in various positions on an orbit proceeding around a common center in a working plane oriented perpendicular to the longitudinal axis.

Abstract translation: 泌尿x射线工作站具有分别支撑在位于患者定位台的纵向侧的装置载体的装置保持器上的x射线源和x射线接收器，使得它们可以彼此相对定位并且独立地定位 在垂直于纵向轴线定向的工作平面中的公共中心周围的轨道上的各种位置。

公开(公告)号：US20090060926A1

公开(公告)日：2009-03-05

申请号：US12203204

申请日：2008-09-03

Applicant: Jens Fehre ,  Ralf Nanke ,  Martin Stetter

Inventor： Jens Fehre ,  Ralf Nanke ,  Martin Stetter

IPC: A61K39/395 ,  A61P35/00

CPC classification number: A61K9/1676 ,  A61K9/0009

Abstract: A medicine for treatment of a carcinoma which can be supplied to the carcinoma via the circulatory system, contains two active components coupled to one another. The first active component is formed of at least one coupling molecule that specifically tethers to a target molecule formed by the cancer tissue. The second active component is formed of at least one signal molecule typical to inflammation, or of at least originating molecule encoding such a signal molecule.

Abstract translation: 用于治疗可以通过循环系统供应给癌症的癌症药物含有彼此偶联的两种活性成分。 第一活性成分由至少一个特异性地束缚于由癌组织形成的靶分子的偶联分子形成。 第二活性成分由至少一种典型的炎症信号分子或至少起码分子编码这种信号分子形成。

公开(公告)号：US09162080B2

公开(公告)日：2015-10-20

申请号：US12094891

申请日：2006-09-28

Applicant: Jens Fehre ,  Bernd Granz ,  Markus Lanski ,  Ralf Nanke

Inventor： Jens Fehre ,  Bernd Granz ,  Markus Lanski ,  Ralf Nanke

IPC: A61B8/12 ,  A61B18/00 ,  A61N5/10 ,  A61B19/00 ,  A61B8/00 ,  A61B8/08

CPC classification number: A61N5/1002 ,  A61B8/4416 ,  A61B8/5261 ,  A61B34/20 ,  A61B2090/378 ,  A61B2090/3925 ,  A61B2090/3983 ,  A61N5/1049 ,  A61N2005/1058 ,  A61N2005/1094

Abstract: In a system and method for x-ray brachytherapy, a probe is introduced into the body of a subject, the probe carrying an x-ray source that radiates x-rays into an exposure area outside of the probe within the body of the subject. A number of markers are located in or on the probe, that are detectable in an image generated by an imaging device. The markers are located in or on the probe in a known spatial relation to the exposure area, so that the position of the exposure area can be determined by identifying the markers in the displayed image.

Abstract translation: 在用于x射线近距离放射疗法的系统和方法中，将探针引入受试者的身体，探头携带将X射线照射到受试者身体内的探针外部的暴露区域中的x射线源。 多个标记物位于探针中或探针上，可由成像装置产生的图像中检测到。 标记以与曝光区域的已知空间关系位于探头中或探针上，从而可以通过识别显示图像中的标记来确定曝光区域的位置。

公开(公告)号：US20130253485A1

公开(公告)日：2013-09-26

申请号：US13615292

申请日：2012-09-13

Applicant: Jens Fehre ,  Andreas Limmer ,  Ralf Nanke ,  Manfred Sechser

Inventor： Jens Fehre ,  Andreas Limmer ,  Ralf Nanke ,  Manfred Sechser

IPC: A61B18/26 ,  H02P29/04

CPC classification number: A61B18/26 ,  A61B6/0407 ,  A61B6/102 ,  A61B6/4405 ,  A61B6/4441 ,  A61B6/46 ,  A61B6/547 ,  A61B6/548 ,  A61B17/225 ,  A61B2017/00017 ,  A61B2090/0801 ,  A61B2090/0807 ,  A61B2090/0808 ,  A61B2090/0811 ,  H02P29/04

Abstract: A system includes at least one device that includes at least one device component. For a defined movement of the at least one device component, a movement axis and/or a movement direction may be selected by a selection element and may be identified by an activatable lighting element. The identified movement axis and/or the identified movement direction may be released by at least one actuation element, so that a desired movement of the at least one device component may be performed.

Abstract translation: 系统包括至少一个包括至少一个设备组件的设备。 对于所述至少一个装置部件的确定的运动，可以通过选择元件选择运动轴和/或运动方向，并且可以由可激活的照明元件来识别。 所确定的运动轴线和/或所识别的移动方向可以由至少一个致动元件释放，使得可以执行至少一个设备部件的期望的移动。

公开(公告)号：US20120252057A1

公开(公告)日：2012-10-04

申请号：US13320610

申请日：2010-05-12

Applicant: Juergen Schrelber ,  Joerg Opitz ,  Carola Gerich ,  Jens Fehre ,  Georg Salomon ,  Ralf Nanke

Inventor： Juergen Schrelber ,  Joerg Opitz ,  Carola Gerich ,  Jens Fehre ,  Georg Salomon ,  Ralf Nanke

IPC: G01N21/64 ,  C12M1/34

CPC classification number: G01N21/6486 ,  A61B5/0059 ,  G01N21/6408

Abstract: The invention relates to a method and to an apparatus for recognizing tumorous living cell tissue. It furthermore relates to a method and to an apparatus for recognizing tumorous cell tissue at collected living cell tissue samples. In the method, electromagnetic radiation is emitted with local definition onto cell tissue by a radiation source and, after deactivation of the radiation source, the decay behavior of the inherent fluorescence intensity of the cell tissue excited by the electromagnetic radiation is detected at the cell tissue in a time resolved and spectrally resolved manner at known sampling rate(s) for at least one wavelength using a detector. The difference autocorrelation function C(t) of the intensity decay behavior is determined using the determined measured intensity values, the fractal dimension DF for the respective irradiated cell tissue is calculated from this and the value of the fractal dimension DF is used for a classification with respect to a presence of a tumor in the respective irradiated cell tissue.

Abstract translation: 本发明涉及用于识别肿瘤活细胞组织的方法和装置。 此外，本发明还涉及用于在收集的活细胞组织样品处识别肿瘤细胞组织的方法和装置。 在该方法中，电磁辐射通过辐射源以局部定义发射到细胞组织上，并且在放射源失活之后，在细胞组织处检测由电磁辐射激发的细胞组织的固有荧光强度的衰变行为 以使用检测器的至少一个波长的已知采样速率以时间分辨和频谱分辨的方式。 使用确定的测量强度值确定强度衰减行为的差分自相关函数C（t），并从其计算相应的照射细胞组织的分形维数DF，并且使用分形维数DF的值进行分类， 相对于各自照射的细胞组织中肿瘤的存在。

公开(公告)号：US20110223109A1

公开(公告)日：2011-09-15

申请号：US12671622

申请日：2008-07-31

Applicant: Jens Fehre ,  Ralf Nanke ,  Martin Stetter

Inventor： Jens Fehre ,  Ralf Nanke ,  Martin Stetter

IPC: A61K49/00

CPC classification number: G01N33/57434 ,  A61K49/0004 ,  G01N2333/71

Abstract: In order to determine the aggressiveness of a prostate tumor, a diagnostic substance is administered to a patient that includes a biomarker provided with a first label that is detectable with a detection device and that specifically binds to a VEGF molecule, and that contains a biomarker that binds specifically to a target molecule that occurs uniformly in the endothelium of blood vessels of healthy tissue and the blood vessels of a prostate tumor, and that is provided with a second label that is detectable with the detection device independently of the first label.

Abstract translation: 为了确定前列腺肿瘤的侵袭性，向患者施用诊断物质，所述患者包括具有可用检测装置检测并且特异性结合VEGF分子的第一标记的生物标志物，并且其含有生物标志物 与在前列腺肿瘤的健康组织和血管的血管的内皮中均匀发生的目标分子特异性结合，并且具有与检测装置独立于第一标记可检测的第二标记。

公开(公告)号：US20090087384A1

公开(公告)日：2009-04-02

申请号：US12203277

申请日：2008-09-03

Applicant: Sueleyman Erguen ,  Jens Fehre ,  Ralf Nanke ,  Bernhard Singer ,  Martin Stetter ,  Derya Tilki

Inventor： Sueleyman Erguen ,  Jens Fehre ,  Ralf Nanke ,  Bernhard Singer ,  Martin Stetter ,  Derya Tilki

IPC: A61K49/22 ,  A61K31/337

CPC classification number: A61K49/223 ,  A61K9/0009 ,  A61K41/0028 ,  A61K47/6843 ,  A61K47/6869 ,  A61K47/6925

Abstract: The invention concerns a medicine for treatment of prostate cancer and a corresponding treatment method. The medicine can be supplied to a prostate tumor through the bloodstream, contains an active component and a binding component as well as ultrasound microbubbles. The binding component includes coupling molecules that specifically bind to a determined target molecule formed in the endothelium of tumor-associated blood vessels and that is typical of the tumor or the tumor stage. The active component contains at least one chemotherapeutic substance. The coupling molecules are bound to the outside of the microbubbles and active substance molecules are likewise bound to the outside of the microbubbles or are enclosed by the microbubbles.

Abstract translation: 本发明涉及用于治疗前列腺癌的药物和相应的治疗方法。 药物可以通过血液供应给前列腺肿瘤，含有活性成分和结合成分以及超声微泡。 结合组分包括与肿瘤相关血管的内皮中形成的确定的靶分子特异性结合并且是肿瘤或肿瘤阶段典型的偶联分子。 活性成分含有至少一种化学物质。 偶联分子结合到微泡的外部，活性物质分子同样地结合到微泡的外部或被微泡封闭。

公开(公告)号：US07449003B2

公开(公告)日：2008-11-11

申请号：US10458095

申请日：2003-06-10

Applicant: Jens Fehre ,  Bernd Granz ,  Christian Meinert ,  Ralf Nanke

Inventor： Jens Fehre ,  Bernd Granz ,  Christian Meinert ,  Ralf Nanke

IPC: A61H1/00

CPC classification number: A61B17/2251

Abstract: A bellows for coupling a source of acoustic waves having an acoustic propagation medium, to a patient, has a geometrical modification in that region wherein the bellows can be seated against the patient for the introduction of acoustic waves into the patient. The geometrical modification in the propagation path of the acoustic waves generated by the source of acoustic waves shapes the acoustic waves in a designated (designed) manner. Additionally or alternatively, the bellows can have a section in the region that is formed of a different material than the rest of the bellows.

Abstract translation: 用于将具有声传播介质的声波源耦合到患者的波纹管在该区域中具有几何修改，其中波纹管可以抵靠患者就座以将声波引入患者体内。 由声波源产生的声波的传播路径中的几何修改以指定（设计）的方式对声波进行整形。 附加地或替代地，波纹管可以具有由与波纹管的其余部分不同的材料形成的区域中的部分。

公开(公告)号：US20060012775A1

公开(公告)日：2006-01-19

申请号：US10535804

申请日：2003-10-07

Applicant: Bernd Granz ,  Ralf Nanke

Inventor： Bernd Granz ,  Ralf Nanke

IPC: G01D5/26

CPC classification number: A61B17/22029 ,  A61B17/22 ,  G01H9/00

Abstract: An optical hydrophone for measurement of the acoustic pressure distribution in a fluid medium has a light source that illuminates an area of a boundary region between an optically transparent body and the fluid medium. A light receiver measures the intensity of the light reflected from the illuminated area as a measurement of acoustic pressure, due to changes in the index of refraction of the fluid medium that are caused by the acoustic pressure. The illuminated area is smaller than the boundary surface formed between the optically transparent body and the fluid medium, thereby giving the hydrophone a longer service light and a high spatial resolution capacity.

Abstract translation: 用于测量流体介质中的声压分布的光学水听器具有照亮光学透明体和流体介质之间的边界区域的区域的光源。 由于由声压引起的流体介质的折射率的变化，光接收器测量从照明区域反射的光的强度作为声压的测量值。 照明区域小于在光学透明体和流体介质之间形成的边界面，从而使水听器具有更长的使用光和高的空间分辨能力。