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公开(公告)号：US20050027150A1
公开(公告)日：2005-02-03
申请号：US10631553
申请日：2003-07-31
申请人： Sherif Eldin , Ronnie Deason , John Link , Tiffany Morris
发明人： Sherif Eldin , Ronnie Deason , John Link , Tiffany Morris
CPC分类号： C08F2/40 , C07C7/20 , Y10S585/95 , C07C15/46
摘要： Quinone methide derivatives such as 4-benzylidene-2,6-di-tert-butyl-cyclohexa-2,5 dienone are used to inhibit styrene monomer polymerization in the dehydrogenator portion of a styrene monomer production system. The inhibitor contacts the dehydrogenation effluent and does not partition in substantial amounts to the aqueous phase that is separated in the phase separator.
摘要翻译： 喹啉酮甲基化物衍生物如4-亚苄基-2,6-二叔丁基环己基-2,5-二烯酮用于抑制苯乙烯单体生产系统的脱氢部分中的苯乙烯单体聚合。 抑制剂与脱氢流出物相接触，并且不大量分配到在相分离器中分离的水相。
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公开(公告)号：US20070088001A1
公开(公告)日：2007-04-19
申请号：US10587867
申请日：2005-01-31
申请人： John Link , Michael Graupe
发明人： John Link , Michael Graupe
IPC分类号： A61K31/695 , C07F7/08
CPC分类号： C07F7/0812 , C07F7/081
摘要： The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is also directed to pharmaceutical compositions comprising these compounds and processes for preparing them. The present invention is also directed to the use of these inhibitors in combination with a therapy that causes a deleterious immune response in patients receiving the therapy.
摘要翻译： 本发明涉及半胱氨酸蛋白酶，特别是组织蛋白酶B，K，L，F和S的抑制剂的化合物，因此可用于治疗由这些蛋白酶介导的疾病。 本发明还涉及包含这些化合物的药物组合物及其制备方法。 本发明还涉及这些抑制剂与在接受治疗的患者中引起有害免疫应答的疗法的组合的用途。
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13.发明申请公开(公告)号：US20060135781A1
公开(公告)日：2006-06-22
申请号：US11347630
申请日：2006-02-02
申请人： Jiayao Li , John Link , Colette Colladant
发明人： Jiayao Li , John Link , Colette Colladant
IPC分类号： C07F3/02
CPC分类号： C07D263/56 , C07D277/64 , C07F3/02
摘要： The present invention is directed to a novel process for preparing heteroaryl and unsaturated heterocycloalkylmagnesium reagents that are useful in the synthesis of a variety of pharmaceuticals, in particular certain cysteine protease inhibitors.
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公开(公告)号：US20050026153A1
公开(公告)日：2005-02-03
申请号：US10631189
申请日：2003-07-31
申请人： Claudia Iannotti , John Link , Barry Boyes
发明人： Claudia Iannotti , John Link , Barry Boyes
CPC分类号： C12N15/1006
摘要： Devices and methods for isolating nucleic acid is disclosed herein. In particular, the isolation of total cellular RNA is discussed. Additionally, devices and methods for reducing genomic DNA in a biological sample without introducing harmful contaminants, and without significantly increasing the time required for the overall procedure being performed on a sample are presented.
摘要翻译： 本文公开了用于分离核酸的装置和方法。 特别地，讨论了总细胞RNA的分离。 另外，提供了用于在不引入有害污染物的情况下还原生物样品中的基因组DNA并且不显着增加对样品进行总体程序所需的时间的装置和方法。
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公开(公告)号：US5213680A
公开(公告)日：1993-05-25
申请号：US812118
申请日：1991-12-20
申请人： Lawrence N. Kremer , John Link , Glenn L. Roof
发明人： Lawrence N. Kremer , John Link , Glenn L. Roof
IPC分类号： C10G29/20
CPC分类号： C10G29/20
摘要： Sour sulfhydryl-group containing oils are treated with an amount of hexamethylenetetramine effective to sweeten the oil and reduce headspace H.sub.2 S to a desired level.
摘要翻译： 含有巯基的油用一定量的六亚甲基四胺进行处理，其有效地使油润湿并将顶部空间H2S减少到所需的水平。
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公开(公告)号：USD325090S
公开(公告)日：1992-03-31
申请号：US443784
申请日：1989-11-30
申请人： Joseph G. Karp , Thomas B. Givens , John Link
设计人： Joseph G. Karp , Thomas B. Givens , John Link
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公开(公告)号：US4488997A
公开(公告)日：1984-12-18
申请号：US412409
申请日：1982-08-27
申请人： Richard F. Miller , John Link
发明人： Richard F. Miller , John Link
CPC分类号： C07C51/412
摘要： Antimony tricarboxylates of higher carboxylic acids can be prepared by(a) reacting antimony oxide with an anhydride of a lower organic acid,(b) reacting the product from (a) with at least one higher carboxylic acid at a temperature sufficient to vaporize volatile material and removing said volatile material, and(c) recovering the antimony tricarboxylate of said higher carboxylic acid.
摘要翻译： 高级羧酸的三羧酸锑可以通过（a）使氧化锑与较低有机酸的酸酐反应来制备，（b）使得产物（a）与至少一种较高级羧酸在足以蒸发挥发性物质的温度下反应 并除去所述挥发性物质，和（c）回收所述较高级羧酸的三羧酸锑。
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18.发明授权Methods and compositions for inhibiting polystyrene formation during styrene production 有权苯乙烯生产过程中抑制聚苯乙烯形成的方法和组合物公开(公告)号：US09206268B2
公开(公告)日：2015-12-08
申请号：US13235004
申请日：2011-09-16
摘要： Methods and compositions are provided for inhibiting the polymerization of a vinyl aromatic monomer, such as styrene monomer, during elevated temperature processing or distillation thereof. The compositions comprise an inhibitor combination of (A) a hydroxylamine and (B) a stable free radical plus a retarder that is either; (C) dinitrobutylphenol or (D) quinone methide. The ratio of (A) to (B) ranges from about 5% (A) to 95% (B) to about 95% (A) to about 5% (B). The compositions are added to the vinyl aromatic monomer in amounts sufficient to prevent polymerization during the distillation process. Typically the inhibitor combination is added to the vinyl aromatic monomer in an amount ranging from about 10 to 150 ppm of the monomer. Retarders are typically added in an amount ranging from 50 to 1500 ppm of the vinyl aromatic monomer.
摘要翻译： 提供了用于在高温处理或蒸馏期间抑制乙烯基芳族单体如苯乙烯单体的聚合的方法和组合物。 组合物包含（A）羟胺和（B）稳定的自由基加上缓凝剂的抑制剂组合; （C）二硝基丁基苯酚或（D）醌甲基化物。 （A）至（B）的比率为约5％（A）至95％（B）至约95％（A）至约5％（B）。 将组合物以足以防止在蒸馏过程中聚合的量加入到乙烯基芳族单体中。 通常将抑制剂组合物加入到单体约10至150ppm范围内的乙烯基芳族单体中。 通常，乙烯基芳族单体的加入量通常为50〜1500ppm。
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公开(公告)号：US20080256729A1
公开(公告)日：2008-10-23
申请号：US11737785
申请日：2007-04-20
申请人： John Link
发明人： John Link
CPC分类号： A61C17/22 , A46B15/0002 , A46B15/0034 , A46B15/0036 , A46B2200/1066 , A61C17/222 , A61C19/066
摘要： A toothbrush for enhancing the whiteness of teeth while carrying out normal prophylactic brushing with a material that includes a light/heat activated whitening agent. The whitening agent is usually activated by light of a certain wavelength. The toothbrush comprises a handle and a head and optical transmission material bringing light of a predetermined frequency to the head portion. The head portion has a clear surface into which the bristles are secured so as to cause light to shine on the teeth surfaces as they are being brushed by the bristles.
摘要翻译： 一种用于增强牙齿白度的牙刷，同时用包含光/热活化的增白剂的材料进行正常的预防性刷牙。 美白剂通常由一定波长的光激活。 牙刷包括手柄和头部以及将预定频率的光引到头部的光学传输材料。 头部具有清晰的表面，刷毛被固定在该清洁表面中，以便当刷毛被刷毛时使得光照在牙齿表面上。
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公开(公告)号：US20070054864A1
公开(公告)日：2007-03-08
申请号：US11478337
申请日：2006-06-28
CPC分类号： A61K38/05 , C07K5/06034
摘要： The present invention is directed to compounds that are antiviral agents. Specifically the compounds of the present invention inhibit replication of HCV and are therefore useful in treating hepatitis C infections. The present invention is also directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
摘要翻译： 本发明涉及作为抗病毒剂的化合物。 具体地说，本发明的化合物抑制HCV的复制，因此可用于治疗丙型肝炎感染。 本发明还涉及包含这些化合物的药物组合物及其制备方法。
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