公开(公告)号：US20210198606A1

公开(公告)日：2021-07-01

申请号：US17136400

申请日：2020-12-29

Applicant: Saint-Gobain Performance Plastics Corporation

Inventor： Katie Campbell ,  Natalie Fekete ,  Rachel Z. Pytel

IPC: C12M1/00 ,  C12M1/12 ,  C12N15/86 ,  C12N15/87

Abstract: This disclosure relates generally to containers (such as bags) having surfaces comprising one or more aptamer sequences. More particularly, the present disclosure relates to containers such as bags comprising a fluoropolymer attached to aptamer sequences having binding affinity for one or more biological agents, and to transductions methods using such containers. In one aspect, the disclosure provides a container (e.g., a bag) having an outer surface and an inner surface, the inner surface comprising a fluoropolymer; attached to the fluoropolymer, a plurality of functional groups; and attached to each of at least a portion of the functional groups, a first aptamer sequence having a binding affinity for a viral vector.

公开(公告)号：US20210178506A1

公开(公告)日：2021-06-17

申请号：US16952414

申请日：2020-11-19

Applicant: SAINT-GOBAIN PERFORMANCE PLASTICS CORPORATION

Inventor： Jianfeng ZHANG ,  Rachel Z. Pytel ,  Anthony P. Pagliaro ,  Clemens E. Zoellner ,  Jian L. Ding ,  Thomas R. Nixon

IPC: B23K10/02 ,  A61L2/14 ,  B23K10/00

Abstract: Systems and methods are disclosed that include generating a plasma treatment and applying the plasma treatment to end contact surfaces of a first profile and a second profile in a sterile environment, manipulating at least one of the first profile and the second profile to force contact between the end contact surface of the first profile and the end contact surface of the second profile to permanently connect, join, or weld the end contact surfaces of the first profile and the second profile together, thereby forming a sterile connection between the first profile and a second profile.

公开(公告)号：US20200207539A1

公开(公告)日：2020-07-02

申请号：US16730477

申请日：2019-12-30

Applicant: SAINT-GOBAIN PERFORMANCE PLASTICS CORPORATION

Inventor： Natasha Anna Boghosian ,  Katie Campbell ,  Jian L. DIng ,  Natalie Fekete ,  Rachel Z. Pytel

IPC: B65D85/50 ,  C08L27/22 ,  C12M1/00

Abstract: This disclosure relates to containers and substrates comprising a fluoropolymer and having a textured inner surface and to methods for cultivating and/or isolating a biological agent using such containers and substrates. In one embodiment, the disclosure provides a container (e.g., in the form of a bag) having an outer surface and a textured inner surface, the inner surface comprising a fluoropolymer, wherein the textured inner surface comprises one or more of (a) a plurality of functional groups attached to the fluoropolymer, and (b) a pattern of spaced features, the features having an average spacing within the range of 0.1 μm to 200 μm.