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公开(公告)号：US10975035B2
公开(公告)日：2021-04-13
申请号：US16379487
申请日：2019-04-09
发明人： Kevin Duane Bunker , Chuangxing Guo , Mark Charles Grier , Chad Daniel Hopkins , Joseph Robert Pinchman , Deborah Helen Slee , Peter Qinhua Huang , Mehmet Kahraman
IPC分类号： C07D213/89 , A61K31/164 , C07C233/05 , C07C233/14 , A61K31/27 , A61K31/13 , C07C211/38 , A61K31/444 , A61K45/06 , C07C317/30 , C07C215/42 , C07C233/06 , C07C233/09 , C07C233/13 , C07C233/23 , A61K31/145 , A61K31/16
摘要： Disclosed herein are compounds of Formulae (I) and (II), methods of synthesizing compounds of Formulae (I) and (II), and methods of using compounds of Formulae (I) and (II) as an analgesic.
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公开(公告)号：US20200270221A1
公开(公告)日：2020-08-27
申请号：US16613397
申请日：2018-05-11
发明人： Chad Daniel Hopkins , Joseph Robert Pinchman , Kevin Duane Bunker , Deborah Helen Slee , Brant Clayton Boren , Mehmet Kahraman
IPC分类号： C07D277/28 , C07C237/04 , C07C271/24 , C07C217/52 , C07C211/38 , C07C215/08 , C07C235/14 , C07C229/14 , C07C211/40 , C07D235/14 , C07D263/56 , C07D239/26 , C07D213/38 , C07D277/64
摘要： Disclosed herein are compounds of Formulae (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It), methods of synthesizing compounds of Formulae (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It), and methods of using compounds of Formulae (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It) as an analgesic.
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公开(公告)号：US20200261428A1
公开(公告)日：2020-08-20
申请号：US16866900
申请日：2020-05-05
发明人： Peter Qinhua Huang , Deborah Helen Slee , Sayee Gajanan Hegde , Chad Daniel Hopkins , Kevin Duane Bunker , Joseph Robert Pinchman , Rakesh Kumar Sit
IPC分类号： A61K31/438 , C07C69/757 , C07B59/00 , C07D471/04 , C07C69/732 , C07C69/738 , A61K31/437 , A61P35/00 , A61P5/30
摘要： Compounds of Formula (I) are estrogen receptor alpha modulators, where the variables in Formula (I) are described in the disclosure. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions that are estrogen receptor alpha dependent and/or estrogen receptor alpha mediated, including conditions characterized by excessive cellular proliferation, such as breast cancer.
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公开(公告)号：US20210395230A1
公开(公告)日：2021-12-23
申请号：US17445280
申请日：2021-08-17
发明人： Kevin Duane Bunker , Peter Qinhua Huang , Sunny Abraham , Joseph Robert Pinchman , Chad Daniel Hopkins , Deborah Helen Slee
IPC分类号： C07D403/04 , A61P35/00 , A61K31/506 , C07D209/04 , C07C13/36 , C07D403/14 , C07D471/04
摘要： Disclosed herein are nitrogen-containing bicyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.
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公开(公告)号：US10959989B2
公开(公告)日：2021-03-30
申请号：US16866995
申请日：2020-05-05
发明人： Peter Qinhua Huang , Deborah Helen Slee , Sayee Gajanan Hegde , Chad Daniel Hopkins , Kevin Duane Bunker , Joseph Robert Pinchman , Rakesh Kumar Sit
IPC分类号： C07D209/10 , A61K31/438 , C07C69/738 , C07C69/732 , C07D471/04 , C07B59/00 , C07C69/757 , A61P5/30 , A61P35/00 , A61K31/437
摘要： Compounds of Formula (I) are estrogen receptor alpha modulators, where the variables in Formula (I) are described in the disclosure. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions that are estrogen receptor alpha dependent and/or estrogen receptor alpha mediated, including conditions characterized by excessive cellular proliferation, such as breast cancer.
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公开(公告)号：US20200268714A1
公开(公告)日：2020-08-27
申请号：US16734857
申请日：2020-01-06
发明人： Peter Qinhua Huang , Mehmet Kahraman , Deborah Helen Slee , Kevin Duane Bunker , Chad Daniel Hopkins , Joseph Robert Pinchman , Sunny Abraham , Rakesh Kumar Sit , Daniel Lee Severance
IPC分类号： A61K31/4162 , C07D487/10 , C07D471/10 , A61P35/00 , A61K31/416
摘要： Disclosed herein are spirocyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.
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公开(公告)号：US20200261429A1
公开(公告)日：2020-08-20
申请号：US16866995
申请日：2020-05-05
发明人： Peter Qinhua Huang , Deborah Helen Slee , Sayee Gajanan Hegde , Chad Daniel Hopkins , Kevin Duane Bunker , Joseph Robert Pinchman , Rakesh Kumar Sit
IPC分类号： A61K31/438 , C07C69/757 , C07B59/00 , C07D471/04 , C07C69/732 , C07C69/738 , A61K31/437 , A61P35/00 , A61P5/30
摘要： Compounds of Formula (I) are estrogen receptor alpha modulators, where the variables in Formula (I) are described in the disclosure. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions that are estrogen receptor alpha dependent and/or estrogen receptor alpha mediated, including conditions characterized by excessive cellular proliferation, such as breast cancer.
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公开(公告)号：US20200181120A1
公开(公告)日：2020-06-11
申请号：US16703544
申请日：2019-12-04
发明人： Kevin Duane Bunker , Peter Qinhua Huang , Sunny Abraham , Joseph Robert Pinchman , Chad Daniel Hopkins , Deborah Helen Slee
IPC分类号： C07D403/04 , C07D471/04 , C07D403/14 , A61K31/506 , A61P35/00
摘要： Disclosed herein are nitrogen-containing bicyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.
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公开(公告)号：US10653681B2
公开(公告)日：2020-05-19
申请号：US16085505
申请日：2017-03-15
发明人： Kevin Duane Bunker , Deborah Helen Slee , Chad Daniel Hopkins , Joseph Robert Pinchman , Mehmet Kahraman , Peter Qinhua Huang
IPC分类号： A61K31/433 , A61K31/137 , A61K31/167 , A61K31/415 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/44 , A61K31/505 , C07D213/38 , C07D271/113 , C07D233/12 , C07D285/08 , C07D277/42 , C07D239/42 , C07C233/07 , C07D263/48 , C07C233/15 , C07D231/12 , A61K31/165 , C07D277/32 , C07D285/12 , C07D277/28 , C07C211/29 , C07C233/13 , C07D277/40 , C07D213/73 , C07D285/125 , C07C233/25 , C07C211/52 , C07D285/135 , A61P29/00 , A61K31/136 , A61K9/00 , A61K45/06
摘要： Disclosed herein are compounds of Formula (I), methods of synthesizing compounds of Formula (I), and methods of using compounds of Formula (I) as an analgesic.
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