公开(公告)号：US20240299395A1

公开(公告)日：2024-09-12

申请号：US18648164

申请日：2024-04-26

Applicant: Recurium IP Holdings, LLC

Inventor： Fernando Donate ,  Laure Escoubet ,  Petrus Rudolf de Jong ,  Hooman Izadi ,  Ahmed Abdi Samatar ,  Brant Clayton Boren ,  Kevin Duane Bunker ,  Peter Qinhua Huang

IPC: A61K31/519 ,  A61K31/5365

CPC classification number: A61K31/519 ,  A61K31/5365

Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer.

公开(公告)号：US20240261295A1

公开(公告)日：2024-08-08

申请号：US18634055

申请日：2024-04-12

Applicant: Recurium IP Holdings, LLC

Inventor： Fernando Donate ,  Hooman Izadi ,  Ahmed Abdi Samatar ,  Brant Clayton Boren ,  Kevin Duane Bunker ,  Peter Qinhua Huang

IPC: A61K31/5365 ,  A61K31/519 ,  A61K39/00 ,  A61P35/00 ,  C07K16/28

CPC classification number: A61K31/5365 ,  A61K31/519 ,  A61P35/00 ,  C07K16/2803 ,  A61K2039/505

Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer.

公开(公告)号：US20230234956A1

公开(公告)日：2023-07-27

申请号：US18001234

申请日：2021-06-09

Applicant: Recurium IP Holdings, LLC

Inventor： Peter Qinhua Huang ,  Chad Daniel Hopkins ,  Brant Clayton Boren ,  Sunny Abraham ,  Kevin Duane Bunker ,  Sobhana Babu Boga ,  Shuguang Zhu ,  Tao Wu ,  Benjamin Pratt

IPC: C07D487/04 ,  C07D221/04

CPC classification number: C07D487/04 ,  C07D221/04 ,  C07B2200/13

Abstract: A process is provided for making a WEE1 inhibitor of the formula (1A) useful in the treatment of conditions characterized by excessive cellular proliferation, such as cancer. In some embodiments, processes are provided for making intermediate compounds of the formulae (3), (5) and (6) as defined herein.

公开(公告)号：US20210139482A1

公开(公告)日：2021-05-13

申请号：US16971254

申请日：2019-02-26

Applicant: Recurium IP Holdings, LLC

Inventor： Peter Qinhua Huang ,  Kevin Duane Bunker ,  Brant Clayton Boren ,  Sayee Gajanan Hegde ,  Hui Liu ,  Aditya Krishnan Unni ,  Sunny Abraham ,  Chad Daniel Hopkins ,  Sunil Paliwal

IPC: C07D487/04 ,  C07D491/048

Abstract: Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.

公开(公告)号：US20200157112A1

公开(公告)日：2020-05-21

申请号：US16635348

申请日：2018-07-31

Applicant: Recurium IP Holdings, LLC

Inventor： Peter Qinhua Huang ,  Brant Clayton Boren ,  Kevin Duane Bunker ,  Hui Liu ,  Sunil Paliwal

IPC: C07D487/04 ,  C07D519/00 ,  A61P35/00

Abstract: Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.

公开(公告)号：US20230002426A1

公开(公告)日：2023-01-05

申请号：US17756011

申请日：2020-11-12

Applicant: Recurium IP Holdings, LLC

Inventor： Sunny Abraham ,  Brant Clayton Boren ,  Sobhana Babu Boga ,  Aditya Krishnan Unni ,  Peter Qinhua Huang ,  Kevin Duane Bunker ,  Benjamin Anthony Pratt

IPC: C07F9/59 ,  C07F9/572

Abstract: Disclosed herein are methods for preparing tertiary alcohols from an optionally substituted phenyl ketone or an optionally substituted pyridinyl ketone that includes the use of a chiral ligand and boron trifluoride diethyl etherate. Tertiary alcohols can be used to prepare synthetic versions of natural products and/or pharmaceuticals.

公开(公告)号：US11124518B2

公开(公告)日：2021-09-21

申请号：US16635348

申请日：2018-07-31

Applicant: Recurium IP Holdings, LLC

Inventor： Peter Qinhua Huang ,  Brant Clayton Boren ,  Kevin Duane Bunker ,  Hui Liu ,  Sunil Paliwal

IPC: C07D487/04 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  C07D519/00

Abstract: Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.

公开(公告)号：US20240391924A1

公开(公告)日：2024-11-28

申请号：US18793337

申请日：2024-08-02

Applicant: Recurium IP Holdings, LLC

Inventor： Peter Qinhua Huang ,  Kevin Duane Bunker ,  Brant Clayton Boren ,  Sayee Gajanan Hegde ,  Hui Liu ,  Aditya Krishnan Unni ,  Sunny Abraham ,  Chad Daniel Hopkins ,  Sunil Paliwal

IPC: C07D487/04 ,  C07D491/048

Abstract: Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.

公开(公告)号：US20230210854A1

公开(公告)日：2023-07-06

申请号：US17998561

申请日：2021-05-12

Applicant: Recurium IP Holdings, LLC

Inventor： Ahmed Abdi Samatar ,  Jiali Li ,  Peter Qinhua Huang ,  Kevin Duane Bunker ,  Fernando Donate ,  Brant Clayton Boren

IPC: A61K31/519 ,  A61P35/00 ,  A61P11/00 ,  A61P15/00 ,  A61P15/08 ,  A61P1/00 ,  A61P19/08 ,  A61K31/5025 ,  A61K31/7068 ,  A61K31/17 ,  A61K31/282 ,  A61K39/395

CPC classification number: A61K31/519 ,  A61K31/17 ,  A61K31/282 ,  A61K31/5025 ,  A61K31/7068 ,  A61K39/3955 ,  A61P1/00 ,  A61P11/00 ,  A61P15/00 ,  A61P15/08 ,  A61P19/08 ,  A61P35/00

Abstract: Disclosed herein are compounds and combinations of compounds for treating a disease or condition, such as cancer.

公开(公告)号：US20230087941A1

公开(公告)日：2023-03-23

申请号：US17757486

申请日：2020-12-16

Applicant: Recurium IP Holdings, LLC

Inventor： Ahmed Abdi Samatar ,  Jiali Li ,  Jianhui Ma ,  Peter Qinhua Huang ,  Sayee Gajanan Hegde ,  Brant Clayton Boren ,  Kevin Duane Bunker ,  Fernando Donate

IPC: A61K31/437 ,  A61K31/519 ,  A61K45/06 ,  A61P35/00

Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer. A combination of compounds for treating a disease or condition can include a SERD inhibitor and a WEE1 inhibitor, along with pharmaceutically acceptable salts of any of the foregoing.