公开(公告)号：US20210139482A1

公开(公告)日：2021-05-13

申请号：US16971254

申请日：2019-02-26

Applicant: Recurium IP Holdings, LLC

Inventor： Peter Qinhua Huang ,  Kevin Duane Bunker ,  Brant Clayton Boren ,  Sayee Gajanan Hegde ,  Hui Liu ,  Aditya Krishnan Unni ,  Sunny Abraham ,  Chad Daniel Hopkins ,  Sunil Paliwal

IPC: C07D487/04 ,  C07D491/048

Abstract: Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.

公开(公告)号：US11261192B2

公开(公告)日：2022-03-01

申请号：US16971254

申请日：2019-02-26

Applicant: Recurium IP Holdings, LLC

Inventor： Peter Qinhua Huang ,  Kevin Duane Bunker ,  Brant Clayton Boren ,  Sayee Gajanan Hegde ,  Hui Liu ,  Aditya Krishnan Unni ,  Sunny Abraham ,  Chad Daniel Hopkins ,  Sunil Paliwal

IPC: C07D487/04 ,  C07D491/048

Abstract: Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.

公开(公告)号：US20230002426A1

公开(公告)日：2023-01-05

申请号：US17756011

申请日：2020-11-12

Applicant: Recurium IP Holdings, LLC

Inventor： Sunny Abraham ,  Brant Clayton Boren ,  Sobhana Babu Boga ,  Aditya Krishnan Unni ,  Peter Qinhua Huang ,  Kevin Duane Bunker ,  Benjamin Anthony Pratt

IPC: C07F9/59 ,  C07F9/572

Abstract: Disclosed herein are methods for preparing tertiary alcohols from an optionally substituted phenyl ketone or an optionally substituted pyridinyl ketone that includes the use of a chiral ligand and boron trifluoride diethyl etherate. Tertiary alcohols can be used to prepare synthetic versions of natural products and/or pharmaceuticals.

公开(公告)号：US20220324775A1

公开(公告)日：2022-10-13

申请号：US17634879

申请日：2020-08-12

Applicant: Recurium IP Holdings, LLC

Inventor： Aditya Krishnan Unni ,  Joseph Robert Pinchman ,  Peter Qinhua Huang ,  Kevin Duane Bunker

IPC: C07C1/28

Abstract: Processes of making [1.1.1]propellane utilize reaction conditions that include reacting 1,1-dibromo-2,2-bis(chloromethyl)cyclopropane with an effective amount of solid magnesium.

公开(公告)号：US20220273666A1

公开(公告)日：2022-09-01

申请号：US17597471

申请日：2020-07-08

Applicant: Recurium IP Holdings, LLC

Inventor： Joseph Robert Pinchman ,  Aditya Krishnan Unni ,  Yosef Shamay ,  Kevin Duane Bunker ,  Peter Qinhua Huang

IPC: A61K31/5377 ,  A61K31/496 ,  A61K9/51 ,  A61K47/64

Abstract: Various albumin nanoparticle Bcl-2 inhibitor formulations are described, along with methods of using them to treat conditions characterized by excessive cellular proliferation, such as cancer and tumors. In various embodiments, such Bcl-2 inhibitor formulations contain albumin and a compound of the following Formula (I), or a pharmaceutically acceptable salt thereof, where the variables in Formula (I) are defined herein.

公开(公告)号：US20240391924A1

公开(公告)日：2024-11-28

申请号：US18793337

申请日：2024-08-02

Applicant: Recurium IP Holdings, LLC

Inventor： Peter Qinhua Huang ,  Kevin Duane Bunker ,  Brant Clayton Boren ,  Sayee Gajanan Hegde ,  Hui Liu ,  Aditya Krishnan Unni ,  Sunny Abraham ,  Chad Daniel Hopkins ,  Sunil Paliwal

IPC: C07D487/04 ,  C07D491/048

Abstract: Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.

公开(公告)号：US20220024939A1

公开(公告)日：2022-01-27

申请号：US17497355

申请日：2021-10-08

Applicant: Recurium IP Holdings, LLC

Inventor： Peter Qinhua Huang ,  Kevin Duane Bunker ,  Brant Clayton Boren ,  Sayee Gajanan Hegde ,  Hui Liu ,  Aditya Krishnan Unni ,  Sunny Abraham ,  Chad Daniel Hopkins ,  Sunil Paliwal

IPC: C07D487/04 ,  C07D491/048

Abstract: Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.

公开(公告)号：US11724971B2

公开(公告)日：2023-08-15

申请号：US17634879

申请日：2020-08-12

Applicant: Recurium IP Holdings, LLC

Inventor： Aditya Krishnan Unni ,  Joseph Robert Pinchman ,  Peter Qinhua Huang ,  Kevin Duane Bunker

IPC: C07C1/28 ,  C07C13/605

CPC classification number: C07C1/28 ,  C07C13/605 ,  C07C2521/10

Abstract: Processes of making [1.1.1]propellane utilize reaction conditions that include reacting 1,1-dibromo-2,2-bis(chloromethyl)cyclopropane with an effective amount of solid magnesium.

公开(公告)号：US20230212118A1

公开(公告)日：2023-07-06

申请号：US17996598

申请日：2021-04-21

Applicant: Recurium IP Holdings, LLC

Inventor： Peter Qinhua Huang ,  Sayee Gajanan Hegde ,  Kevin Duane Bunker ,  John Knight ,  Joseph Robert Pinchman ,  Aditya Krishnan Unni ,  Rakesh Kumar Sit ,  Shuguang Zhu ,  Chad Daniel Hopkins ,  Ian Scott

IPC: C07D209/16 ,  C07D471/04 ,  B01J31/12 ,  B01J23/44 ,  B01J23/02

CPC classification number: C07D209/16 ,  C07D471/04 ,  B01J31/122 ,  B01J23/44 ,  B01J23/02 ,  C07B2200/13

Abstract: Described herein is a method for obtaining a selective estrogen receptor degrader, and compounds used in preparing the selective estrogen receptor degrader.

公开(公告)号：US20230159416A1

公开(公告)日：2023-05-25

申请号：US17904477

申请日：2021-02-17

Applicant: Recurium IP Holdings, LLC

Inventor： Aditya Krishnan Unni ,  Joseph Robert Pinchman ,  Peter Qinhua Huang ,  Kevin Duane Bunker

IPC: C07C17/363 ,  C07C17/275

CPC classification number: C07C17/363 ,  C07C17/275 ,  C07C2602/38

Abstract: The present application is related to an improved process for synthesising 1-(difluoromethyl)-3-iodobicyclo[1.1.1]pentane from difluoromethyl iodide and [1.1.1]propellane. Difluoromethyl iodide is made by reacting an iodide salt with chlorodifluoroacetic acid in the presence of a solvent such as sulfolane and an inorganic base, [1.1.1]propellane is synthesised by reacting 1,1-dibromo-2,2-cis(chloromethyl)cyclopropane with a reagent such as magnesium, methyllithium or phenyllithium.