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    ION FOCUSING
    12.
    发明公开
    ION FOCUSING 审中-公开

    公开(公告)号：US20240186133A1

    公开(公告)日：2024-06-06

    申请号：US18520974

    申请日：2023-11-28

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Zane Baird ,  Wen-Ping Peng

    IPC: H01J49/06 ,  H01J49/10 ,  H01J49/16 ,  H01J49/26

    CPC classification number: H01J49/067 ,  H01J49/06 ,  H01J49/10 ,  H01J49/165 ,  H01J49/26

    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.

    MASS TAG ANALYSIS FOR RARE CELLS AND CELL FREE MOLECULES
    18.
    发明申请
    MASS TAG ANALYSIS FOR RARE CELLS AND CELL FREE MOLECULES 有权

    公开(公告)号：US20230115304A1

    公开(公告)日：2023-04-13

    申请号：US18075578

    申请日：2022-12-06

    Applicant: Purdue Research Foundation

    Inventor： Zane Baird ,  Robert Graham Cooks ,  Adam Hollerbach ,  Zheng Ouyang ,  Michael Pugia

    IPC: G01N33/53

    Abstract: The invention generally relates to mass tag analysis for rare cells and cell free molecules. In certain embodiments, the invention provides an apparatus including an essentially non-absorbent membrane having at least one pore, a microwell operably associated with the essentially non-absorbent membrane, and an electric field generator. The apparatus may be configured such that an electric field produced by the electric field generator operably interacts with a sample in the microwell and expels a droplet of the sample through the at least one pore in the essentially non-absorbent membrane. In certain embodiments, apparatuses of the invention are used for detection, and optionally quantification, of a target analyte from a heterogeneous sample, such as a rare target analyte (e.g., rare cell) from a biological sample.

    ION FOCUSING
    19.
    发明申请
    ION FOCUSING 有权

    公开(公告)号：US20220216046A1

    公开(公告)日：2022-07-07

    申请号：US17148737

    申请日：2021-01-14

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Zane Baird ,  Wen-Ping Peng

    IPC: H01J49/06 ,  H01J49/10 ,  H01J49/16 ,  H01J49/26

    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.

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