公开(公告)号：US10045722B2

公开(公告)日：2018-08-14

申请号：US14199497

申请日：2014-03-06

Applicant: Profusa, Inc.

Inventor： Gregory J. Kintz ,  William McMillan ,  Natalie Wisniewski

IPC: A61B5/00 ,  A61B5/1459 ,  A61B5/145

Abstract: An optical device is used to monitor an implant embedded in the tissue of a mammal (e.g., under the skin). The implant receives excitation light from the optical device and emits light that is detected by the optical device, including an analyte-dependent optical signal. Scatter and absorption properties of tissue change over time due to changes in hydration, blood perfusion and oxygenation. The optical device has an arrangement of light sources, filters and detectors to transmit excitation light within excitation wavelength ranges and to measure emitted light within detection wavelengths. Changes in scattering and absorption of light in the tissue, such as diffuse reflectance, are monitored. The light sources, filters and detectors may also be used to monitor autofluorescence in the tissue to correct autofluorescence background.

公开(公告)号：US20180184956A1

公开(公告)日：2018-07-05

申请号：US15830798

申请日：2017-12-04

Applicant: Profusa, Inc.

Inventor： Soya Gamsey ,  Natalie Wisniewski ,  Kristen Helton ,  William McMillan

IPC: A61B5/1455 ,  C07F15/00 ,  A61B5/145 ,  A61K49/00 ,  G01N33/497 ,  C12Q1/54 ,  C09K11/06 ,  A61B5/00

CPC classification number: A61B5/14552 ,  A61B5/0059 ,  A61B5/14532 ,  A61B2503/40 ,  A61K49/0036 ,  A61K49/0054 ,  A61K49/0073 ,  C07F15/0066 ,  C09K11/06 ,  C09K2211/185 ,  C12Q1/54 ,  G01N33/497 ,  G01N2333/904

Abstract: Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.

公开(公告)号：US12048535B2

公开(公告)日：2024-07-30

申请号：US17114698

申请日：2020-12-08

Applicant: Profusa, Inc.

Inventor： Soya Gamsey ,  Natalie Wisniewski ,  Kristen Helton ,  William A. McMillan

IPC: A61K49/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  C07F15/00 ,  C09K11/06 ,  C12Q1/54 ,  G01N33/497

CPC classification number: A61B5/14552 ,  A61B5/14532 ,  A61K49/0036 ,  A61K49/0054 ,  A61K49/0073 ,  C07F15/0066 ,  C09K11/06 ,  C12Q1/54 ,  G01N33/497 ,  A61B5/0059 ,  A61B2503/40 ,  C09K2211/185 ,  G01N2333/904

Abstract: Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.

公开(公告)号：US09867560B2

公开(公告)日：2018-01-16

申请号：US15189448

申请日：2016-06-22

Applicant: Profusa, Inc.

Inventor： Soya Gamsey ,  Natalie Wisniewski ,  Kristen Helton ,  William McMillan

IPC: A61K49/00 ,  A61B5/1455 ,  A61B5/145 ,  C07F15/00 ,  C09K11/06 ,  C12Q1/54 ,  G01N33/497 ,  A61B5/00

CPC classification number: A61B5/14552 ,  A61B5/0059 ,  A61B5/14532 ,  A61B2503/40 ,  A61K49/0036 ,  A61K49/0054 ,  A61K49/0073 ,  C07F15/0066 ,  C09K11/06 ,  C09K2211/185 ,  C12Q1/54 ,  G01N33/497 ,  G01N2333/904

Abstract: Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.

公开(公告)号：US20140286875A1

公开(公告)日：2014-09-25

申请号：US14209252

申请日：2014-03-13

Applicant: Profusa, Inc.

Inventor： Soya Gamsey ,  Natalie Wisniewski ,  Kristen Helton ,  William McMillan

IPC: A61K49/00

CPC classification number: A61B5/14552 ,  A61B5/0059 ,  A61B5/14532 ,  A61B2503/40 ,  A61K49/0036 ,  A61K49/0054 ,  A61K49/0073 ,  C07F15/0066 ,  C09K11/06 ,  C09K2211/185 ,  C12Q1/54 ,  G01N33/497 ,  G01N2333/904

Abstract: Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.

Abstract translation: 提供了氧感测发光染料，包含这些传感器的聚合物和传感器以及使用这些传感器和系统的方法。