公开(公告)号：US20060170916A1

公开(公告)日：2006-08-03

申请号：US11045051

申请日：2005-01-31

Applicant: Thomas Voigt ,  David Tuschel ,  Jingyun Zhang ,  Patrick Treado

Inventor： Thomas Voigt ,  David Tuschel ,  Jingyun Zhang ,  Patrick Treado

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0224 ,  G01N21/65

Abstract: The disclosure relates to identifying one or more regions of interest within a broader field of view of a dynamic sample using one or more optical components and illuminating photons. Once the region of interest is identified within a section of the broader field of view, chemical information in the form of Raman spectrum is obtained from the region of interest by focusing the illuminating photons or the optical components on the region of interest.

Abstract translation: 本公开涉及使用一个或多个光学组件和照射光子来识别动态样本的更宽视野内的一个或多个感兴趣区域。 一旦在较宽视场的一部分内识别出感兴趣区域，则通过将照射光子或光学部件聚焦在感兴趣区域上，从感兴趣的区域获得拉曼光谱形式的化学信息。

公开(公告)号：US20060157652A1

公开(公告)日：2006-07-20

申请号：US11366887

申请日：2006-03-02

Applicant: Patrick Treado ,  Matthew Nelson ,  Scott Keitzer

Inventor： Patrick Treado ,  Matthew Nelson ,  Scott Keitzer

IPC: G01N21/35

CPC classification number: G01N21/359 ,  G01J3/2823 ,  G02B21/0016 ,  G02B21/06

Abstract: A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.

公开(公告)号：US20050030657A1

公开(公告)日：2005-02-10

申请号：US10893332

申请日：2004-07-19

Applicant: John Maier ,  Patrick Treado ,  Chenhui Wang

Inventor： John Maier ,  Patrick Treado ,  Chenhui Wang

IPC: G01B9/02 ,  G01J20060101 ,  G01J3/02 ,  G01J3/10 ,  G01J3/28 ,  G01J3/30 ,  G01J3/44 ,  G01N21/64 ,  G01N21/65 ,  G02F1/1333 ,  G02F1/1335 ,  G02F1/1347

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/0229 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0283 ,  G01J3/10 ,  G01J3/44 ,  G01J3/4406 ,  G01N21/6456 ,  G01N2021/6417 ,  G01N2021/6423 ,  G01N2021/6471 ,  G01N2201/0221 ,  G01N2201/0627 ,  G02F1/133371 ,  G02F1/1347

Abstract: The disclosure generally relates to a method and apparatus for multi-wavelength imaging spectrometer. More specifically, in one embodiment, the disclosure relates to an optical filter for passing photons therethrough. The filter includes a first filter stage and a second filter stage. The first filter stage may include a first retarder element and a first liquid crystal cell. The first element may include an input face and an output face. One of the first element faces is not oriented substantially normal to the trajectory of photons passing through the filter.

Abstract translation: 本公开一般涉及用于多波长成像光谱仪的方法和装置。 更具体地，在一个实施例中，本发明涉及一种用于使光子通过其的滤光器。 该滤波器包括第一滤波器级和第二滤波级。 第一滤波器级可以包括第一延迟元件和第一液晶单元。 第一元件可以包括输入面和输出面。 第一元件面之一不是基本上垂直于通过过滤器的光子的轨迹。

公开(公告)号：US09103714B2

公开(公告)日：2015-08-11

申请号：US12924831

申请日：2010-10-06

Applicant: Patrick Treado ,  Matthew Nelson ,  Charles W. Gardner, Jr.

Inventor： Patrick Treado ,  Matthew Nelson ,  Charles W. Gardner, Jr.

IPC: G01J3/02 ,  G01J3/44 ,  G01N21/359 ,  G01N33/00

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/027 ,  G01J3/0278 ,  G01J3/44 ,  G01N21/359 ,  G01N33/0057

Abstract: A system and method for detecting explosives and explosive residues. A region of interest is surveyed using a video capture device to thereby identify a target area wherein the target area comprises an unknown material. The target area is interrogated using SWIR spectroscopic methods to form a SWIR hyperspectral image of the target area. The SWIR hyperspectral image is analyzed to thereby identify the unknown material.

Abstract translation: 爆炸物和爆炸物残留物的检测系统和方法。 使用视频捕获装置测量感兴趣的区域，从而识别目标区域，其中目标区域包括未知材料。 使用SWIR光谱方法询问目标区域以形成目标区域的SWIR高光谱图像。 分析SWIR高光谱图像，从而识别未知物质。

公开(公告)号：US20130341509A1

公开(公告)日：2013-12-26

申请号：US13134978

申请日：2011-06-22

Applicant: Matthew Nelson ,  Patrick Treado ,  Charles Gardner, JR.

Inventor： Matthew Nelson ,  Patrick Treado ,  Charles Gardner, JR.

IPC: G01J5/02 ,  H01L31/00

CPC classification number: G01J3/0208 ,  G01J3/0224 ,  G01J3/0248 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/0272 ,  G01J3/0283 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/1256 ,  G01J3/26 ,  G01J3/2823 ,  G01J3/42 ,  G01N21/359 ,  G01N33/227 ,  G01N2201/0221 ,  G01N2201/067 ,  G01N2201/129

Abstract: The present disclosure provides for a portable device for detecting the presence of explosive materials, including bulk explosive materials and out-gassed by products of explosive materials. The portable device may comprise a tunable filter and a NIR detector, configured so as to generate a NIR hyperspectral image representative of a target. The portable device may also comprise a RGB detector configured to generate a video image of a region of interest. The disclosure also provides for a method of detecting explosive materials using NIR hyperspectral imaging which may comprise collecting interacted photons, passing the interacted photons through a tunable filter, and detecting the interacted photons to generate a NIR hyperspectral image representative of a target. The method may also comprise surveying a region of interest using a RGB detector to identify a target for further inspection using NIR hyperspectral imaging.

Abstract translation: 本公开提供了一种便携式装置，用于检测爆炸物质的存在，包括爆炸物质的爆炸物质和由爆炸物质的产物冒出的气体。 便携式设备可以包括可调谐滤波器和NIR检测器，其被配置为产生代表目标的NIR高光谱图像。 便携式设备还可以包括被配置为生成感兴趣区域的视频图像的RGB检测器。 本公开还提供了使用NIR高光谱成像检测爆炸性材料的方法，其可以包括收集相互作用的光子，使相互作用的光子通过可调谐滤光器，并且检测相互作用的光子以产生代表目标的NIR高光谱图像。 该方法还可以包括使用RGB检测器来测量感兴趣的区域，以使用NIR高光谱成像识别用于进一步检查的目标。

公开(公告)号：US08436987B2

公开(公告)日：2013-05-07

申请号：US13209670

申请日：2011-08-15

Applicant: Jeffrey Beckstead ,  Patrick Treado ,  Matthew Nelson

Inventor： Jeffrey Beckstead ,  Patrick Treado ,  Matthew Nelson

IPC: G01N21/00

Abstract: A system and method for locating and identifying unknown samples. A targeting mode may be utilized to scan regions of interest for potential unknown materials. This targeting mode may interrogate regions of interest using SWIR and/or fluorescence spectroscopic and imaging techniques. Unknown samples detected in regions of interest may be further interrogated using a combination of Raman and LIBS techniques to identify the unknown samples. Structured illumination may be used to interrogate an unknown sample. Data sets generated during interrogation may be compared to a reference database comprising a plurality of reference data sets, each associated with a known material. The system and method may be used to identify a variety of materials including: biological, chemical, explosive, hazardous, concealment, and non-hazardous materials.

公开(公告)号：US08395769B2

公开(公告)日：2013-03-12

申请号：US12834462

申请日：2010-07-12

Applicant: Shona Stewart ,  John Maier ,  Patrick Treado

Inventor： Shona Stewart ,  John Maier ,  Patrick Treado

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/65 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/658 ,  G01N33/1826

Abstract: A method for assessing the presence of a pathogenic microorganism in a sample. A sample is illuminated to thereby produce a first plurality of interacted photons which may be scattered, emitted, reflected and/or absorbed by the sample. The first plurality of interacted photons are assessed to thereby generate a Raman data set representative of the sample. This Raman data set is analyzed to thereby determine at least one of: the presence of a pathogenic microorganism in said sample and the absence of a pathogenic microorganism in said sample. The Raman data set may comprise at least one of a Raman spectrum and/or a Raman chemical image representative of the sample. The analysis may comprise comparing said Raman data set to at least one reference Raman data set representative of a known sample. This may be achieved using a chemometric technique.

Abstract translation: 用于评估样品中病原微生物的存在的方法。 照射样品从而产生可被样品散射，发射，反射和/或吸收的第一多个相互作用的光子。 评估第一组多个相互作用的光子，从而产生代表样品的拉曼数据集。 分析该拉曼数据集，从而确定所述样品中病原微生物的存在和所述样品中不存在致病微生物中的至少一种。 拉曼数据集可以包括代表样品的拉曼光谱和/或拉曼化学图像中的至少一个。 分析可以包括将所述拉曼数据集与代表已知样本的至少一个参考拉曼数据集进行比较。 这可以使用化学计量技术来实现。

公开(公告)号：US08368880B2

公开(公告)日：2013-02-05

申请号：US12754229

申请日：2010-04-05

Applicant: Patrick Treado ,  Matthew Nelson ,  Charles W. Gardner, Jr.

Inventor： Patrick Treado ,  Matthew Nelson ,  Charles W. Gardner, Jr.

IPC: G01N21/00

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/44 ,  G01N21/3563 ,  G01N21/359 ,  G01N33/0057

Abstract: A sample is illuminated to thereby generate a plurality of first interacted photons selected. The first interacted photons are assessed using a visible imaging device to thereby determine an area of interest in the sample. The area of interest is illuminated to thereby generate a plurality of second interacted photons. The second interacted photons are assessed using a spectroscopic device to thereby generate a SWIR data set representative of said area of interest. A database is searched wherein said database comprises a plurality of known SWIR data sets associated with an explosive material. The data sets comprise at least one of: a plurality of SWIR spectra and a plurality of spatially accurate wavelength resolved SWIR images. An explosive material in the area of interest is thereby identified as a result of the search.

Abstract translation: 照射样品从而产生选择的多个第一相互作用的光子。 使用可见成像装置评估第一相互作用的光子，从而确定样品中的感兴趣区域。 感兴趣的区域被照亮，从而产生多个第二相互作用的光子。 使用光谱装置评估第二相互作用的光子，从而产生表示所述感兴趣区域的SWIR数据集。 搜索数据库，其中所述数据库包括与爆炸物质相关联的多个已知的已知SWIR数据集。 数据组包括多个SWIR光谱和多个空间准确的波长分辨的SWIR图像中的至少一个。 因此，在感兴趣区域中的爆炸性材料被确定为搜索的结果。

公开(公告)号：US20120200850A1

公开(公告)日：2012-08-09

申请号：US13098832

申请日：2011-05-02

Applicant: Shona Stewart ,  John Maier ,  Patrick Treado

Inventor： Shona Stewart ,  John Maier ,  Patrick Treado

IPC: G01J3/44

CPC classification number: G01N21/65 ,  G01N2021/656

Abstract: Raman molecular imaging (RMI) is used to detect mammalian cells of a particular phenotype. The disclosure includes the use of RMI to detect transplanted and/or grafted cells, to differentiate between normal and diseased cells or tissues, as well as in determining the grade of said cancer cells. Raman scattering data may be analyzed to determine the transplant efficiency, disease state, clinical outcome, and/or prognosis of cells or tissue. This data may be combined with visual image data to produce hybrid images which depict both a magnified view of the cellular structures and information relating to the disease state of the individual cells in the field of view. Also, RMI techniques may be combined with visual image data and validated with other detection methods to produce confirm the matter obtained by RMI.

Abstract translation: 拉曼分子成像（RMI）用于检测特定表型的哺乳动物细胞。 本公开内容包括使用RMI来检测移植和/或接种的细胞，以区分正常和患病的细胞或组织，以及确定所述癌细胞的等级。 可以分析拉曼散射数据以确定细胞或组织的移植效率，疾病状态，临床结果和/或预后。 该数据可以与视觉图像数据组合以产生描绘细胞结构的放大视图和与视野中的各个细胞的疾病状态有关的信息的混合图像。 此外，RMI技术可以与可视图像数据组合，并用其他检测方法验证，以确定RMI获得的事项。

公开(公告)号：US20120133775A1

公开(公告)日：2012-05-31

申请号：US13020997

申请日：2011-02-04

Applicant: Patrick Treado ,  Charles W. Gardner, JR. ,  Matthew Nelson ,  Ryan Priore

Inventor： Patrick Treado ,  Charles W. Gardner, JR. ,  Matthew Nelson ,  Ryan Priore

IPC: H01L27/146 ,  H04N5/33

CPC classification number: G01J3/32 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0264 ,  G01J3/0289 ,  G01J3/36 ,  G01J3/4338 ,  G01J3/44 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N33/0057

Abstract: A system and method for hyperspectral imaging to detect hazardous agents including explosive agents. A system comprising a tunable laser, a collection optics, and one or more hyperspectral imaging detectors configured for hyperspectral imaging of a target comprising an unknown material. A method comprising illuminating a target comprising an unknown material via a tunable laser to thereby generate a plurality of interacted photons. Detecting said interacted photons to generate at least one hyperspectral image representative of the target. One or more hyperspectral images may be obtained including SWIR, MWIR, and LWIR hyperspectral images. Algorithms and chemometric techniques may be applied to assess the hyperspectral images to identify the unknown material as comprising an explosive agent or a non-explosive agent. A video imaging device may also be configured to provide a video image of an area of interest, which may be assessed to identify a target for interrogation using hyperspectral imaging.

Abstract translation: 用于高光谱成像检测危险物质（包括爆炸物）的系统和方法。 一种包括可调激光器，收集光学器件和一个或多个高光谱成像检测器的系统，其被配置用于包含未知材料的靶的超光谱成像。 一种方法，包括通过可调激光照射包括未知材料的靶，从而产生多个相互作用的光子。 检测所述相互作用的光子以产生代表目标的至少一个高光谱图像。 可以获得一个或多个高光谱图像，包括SWIR，MWIR和LWIR高光谱图像。 可以应用算法和化学计量技术来评估高光谱图像以将未知材料识别为包括爆炸剂或非爆炸剂。 视频成像装置还可以被配置为提供感兴趣区域的视频图像，其可以被评估以使用高光谱成像识别用于询问的目标。