-
公开(公告)号：US20220024964A1
公开(公告)日：2022-01-27
申请号：US17299350
申请日：2019-12-02
Applicant: Merck Sharp & Dohme Corp.
Inventor： Michael D. Altman , Wonsuk Chang , Jared N. Cumming , Hong Liu , Benjamin Wesley Trotter
Abstract: A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2a, R3, R3a, R4, R5, R5a, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds (I).
-
![Benzo[b]thiophene compounds as STING agonists](/abs-image/US/2020/08/04/US10730849B2/abs.jpg.150x150.jpg)
公开(公告)号：US10730849B2
公开(公告)日：2020-08-04
申请号：US16513417
申请日：2019-07-16
Applicant: MERCK SHARP & DOHME CORP.
Inventor： Michael D. Altman , Brandon D. Cash , Wonsuk Chang , Jared N. Cumming , Andrew M. Haidle , Timothy J. Henderson , James P. Jewell , Matthew A. Larsen , Rui Liang , Jongwon Lim , Min Lu , Ryan D. Otte , Tony Siu , Benjamin Wesley Trotter , Sriram Tyagarajan
IPC: C07D333/60 , C07D333/62 , C07D409/12 , C07D498/04
Abstract: Compounds of general formula (Ia), compounds of general formula (Ia′), compounds of general formula (Ib), compounds of general formula (Ib′), compounds of general formula (I), compounds of general formula (I′), and their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, R6, R8, R9, X1, X2, and X3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds of the disclosure.
-
![Benzo[b]thiophene compounds as STING agonists](/abs-image/US/2020/07/07/US10703738B2/abs.jpg.150x150.jpg)
公开(公告)号：US10703738B2
公开(公告)日：2020-07-07
申请号：US16513409
申请日：2019-07-16
Applicant: MERCK SHARP & DOHME CORP.
Inventor： Michael D. Altman , Brandon D. Cash , Wonsuk Chang , Jared N. Cumming , Andrew M. Haidle , Timothy J. Henderson , James P. Jewell , Matthew A. Larsen , Rui Liang , Jongwon Lim , Min Lu , Ryan D. Otte , Tony Siu , Benjamin Wesley Trotter , Sriram Tyagarajan
IPC: C07D333/60 , C07D333/62 , C07D409/12 , C07D498/04
Abstract: Compounds of general formula (Ia), compounds of general formula (Ia′), compounds of general formula (Ib), compounds of general formula (Ib′), compounds of general formula (I), compounds of general formula (I′), and their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, R6, R8, R9, X1, X2, and X3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds of the disclosure.
-
![BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS](/abs-image/US/2019/11/07/US20190337917A1/abs.jpg.150x150.jpg)
公开(公告)号：US20190337917A1
公开(公告)日：2019-11-07
申请号：US16513409
申请日：2019-07-16
Applicant: MERCK SHARP & DOHME CORP.
Inventor： Michael D. Altman , Brandon D. Cash , Wonsuk Chang , Jared N. Cumming , Andrew M. Haidle , Timothy J. Henderson , James P. Jewell , Matthew A. Larsen , Rui Liang , Jongwon Lim , Min Lu , Ryan D. Otte , Tony Siu , Benjamin Wesley Trotter , Sriram Tyagarajan
IPC: C07D333/60 , C07D498/04 , C07D333/62 , C07D409/12
Abstract: Compounds of general formula (Ia), compounds of general formula (Ia′), compounds of general formula (Ib), compounds of general formula (Ib′), compounds of general formula (I), compounds of general formula (I′), and their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, R6, R8, R9, X1, X2, and X3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds of the disclosure.
-
公开(公告)号：US10106574B2
公开(公告)日：2018-10-23
申请号：US15234182
申请日：2016-08-11
Applicant: Merck Sharp & Dohme Corp.
Inventor： Michael D. Altman , Wonsuk Chang , Jared N. Cumming , Rui Liang , Jongwon Lim , Tony Siu , Benjamin Wesley Trotter , Quang T. Truong , Shawn P. Walsh
IPC: A61K31/70 , A01N43/04 , C07H21/04 , C07H21/02 , A61K39/39 , C07H19/20 , C07H19/23 , C07H21/00 , A61K31/7064 , A61K31/7084 , A61K31/708 , A61K31/706 , A61K31/7076
Abstract: A class of polycyclic compounds of general formula (I), of general formula (I′), or of general formula (I″), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
-
Patent Agency Ranking
公开(公告)号：US20180237469A1
公开(公告)日：2018-08-23
申请号：US15886578
申请日：2018-02-01
Applicant: Merck Sharp & Dohme Corp.
Inventor： Michael D. Altman , Brian Andresen , Wonsuk Chang , Matthew Lloyd Childers , Jared N. Cumming , Andrew Marc Haidle , Timothy J. Henderson , James P. Jewell , Rui Liang , Jongwon Lim , Hong Liu , Min Lu , Alan B. Northrup , Ryan D. Otte , Tony Siu , Benjamin Wesley Trotter , Quang T. Truong , Shawn P. Walsh , Kake Zhao
IPC: C07H21/04 , C07H19/23 , C07H21/00 , C07H19/20 , A61K39/39 , C07H21/02 , A61K31/7076 , A61K31/708 , A61K31/706 , A61K31/7084 , A61K31/7064
Abstract: A class of polycyclic compounds of general formula (I), of general formula (I′), or of general formula (I″), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
-
公开(公告)号：US11466047B2
公开(公告)日：2022-10-11
申请号：US16611624
申请日：2018-05-07
Applicant: Merck Sharp & Dohme Corp. , Wen-Lian Wu , Jongwon Lim , Jared N. Cumming , Benjamin Wesley Trotter , Wonsuk Chang
Inventor： Wen-Lian Wu , Jongwon Lim , Jared N. Cumming , Benjamin Wesley Trotter , Wonsuk Chang
Abstract: A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
-
公开(公告)号：US11453697B1
公开(公告)日：2022-09-27
申请号：US16904888
申请日：2020-06-18
Applicant: Merck Sharp & Dohme Corp.
Inventor： Michael D. Altman , Brian Andresen , Wonsuk Chang , Jared N. Cumming , Ryan D. Otte , Benjamin Wesley Trotter
IPC: A01N43/04 , A61K31/70 , C07H21/04 , C07H21/02 , A61K39/39 , C07H19/20 , C07H19/23 , A61P35/00 , C07H21/00 , A61K31/7076 , A61K31/7064 , A61K31/7084 , A61K31/708 , A61K31/706
Abstract: A class of polycyclic compounds of general formula (I), of general formula (I′), or of general formula (I″), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
-
公开(公告)号：US20220033435A1
公开(公告)日：2022-02-03
申请号：US17299355
申请日：2019-12-02
Applicant: Merck Sharp & Dohme Corp.
Inventor： Michael D. Altman , Wonsuk Chang , Jared N. Cumming , Hong Liu , Benjamin Wesley Trotter
IPC: C07H21/04
Abstract: A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3a, R4, R5, R5a, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds (I).
-
公开(公告)号：US20220033431A1
公开(公告)日：2022-02-03
申请号：US17299359
申请日：2019-12-02
Applicant: Merck Sharp & Dohme Corp.
Inventor： Michael D. Altman , Wonsuk Chang , Jared N. Cumming , Hong Liu , Benjamin Wesley Trotter
Abstract: A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2a, R3, R3a, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds. (I)
-
-
-
-
-
-
-
-
-
Search Results
24
records
(took 0.034 seconds)
