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    INTRAVESICAL DRUG DELIVERY DEVICES
    11.
    发明申请
    INTRAVESICAL DRUG DELIVERY DEVICES 审中-公开

    公开(公告)号：US20200254217A1

    公开(公告)日：2020-08-13

    申请号：US16847862

    申请日：2020-04-14

    Applicant: Massachusetts Institute of Technology

    Inventor： Michael J. Cima ,  Heejin Lee

    IPC: A61M25/01 ,  A61M31/00 ,  A61K31/167 ,  A61K9/00

    Abstract: An implantable medical device is provided for controlled drug delivery within the bladder, or other body vesicle. The device may include at least one drug reservoir component comprising a drug; and a vesicle retention frame which comprises an elastic wire having a first end, an opposing second end, and an intermediate region therebetween, wherein the drug reservoir component is attached to the intermediate region of the vesicle retention frame. The retention frame prevents accidental voiding of the device from the bladder, and it preferably has a spring constant selected for the device to effectively stay in the bladder during urination while minimizing the irritation of the bladder.

    SINGLE-SIDED MAGNETS FOR REMOTE NUCLEAR MAGNETIC RESONANCE MEASUREMENTS
    13.
    发明申请
    SINGLE-SIDED MAGNETS FOR REMOTE NUCLEAR MAGNETIC RESONANCE MEASUREMENTS 审中-公开

    公开(公告)号：US20180306879A1

    公开(公告)日：2018-10-25

    申请号：US15957429

    申请日：2018-04-19

    Applicant: Massachusetts Institute of Technology

    Inventor： Ashvin Bashyam ,  Michael J. Cima ,  Matthew Li

    IPC: G01R33/38 ,  A61B5/055

    CPC classification number: G01R33/3808 ,  A61B5/055 ,  G01R33/383

    Abstract: A Unilateral Linear Halbach magnet configuration includes a central magnetized region recessed relative to adjacent magnetized regions disposed on opposite sides of the central magnetized region. The Unilateral Linear Halbach magnet configuration further includes side (or outer) magnetized regions disposed adjacent the center-adjacent magnetized regions. The center and center-adjacent magnetized regions have like-pointing magnetization vectors while the magnetization vectors of the side magnetized regions point in directions orthogonal to the magnetization vectors of the center and center-adjacent regions. Further, the magnetization vectors of the side magnetized regions point in opposite directions.

    Systems and methods for delivering chemical and electrical stimulation across one or more neural circuits
    18.
    发明授权
    Systems and methods for delivering chemical and electrical stimulation across one or more neural circuits 有权

    公开(公告)号：US10933218B2

    公开(公告)日：2021-03-02

    申请号：US14908586

    申请日：2014-07-30

    Applicant: Massachusetts Institute of Technology

    Inventor： Byron C. Masi ,  Patrick L. Tierney ,  Ann M. Graybiel ,  Michael J. Cima

    IPC: A61M25/00 ,  A61B5/04 ,  A61M1/12 ,  A61N1/05 ,  A61N1/04 ,  A61B5/00 ,  A61N1/00

    Abstract: Systems, devices, and methods are provided for delivering chemical and electrical stimulation across one or more neural circuits. The systems, devices, and methods can also be used for sensing and recording specific neural activity. In certain embodiments, a system includes first and second fluid reservoirs, a manifold, and a delivery tube. The manifold may include first and second chambers therein. The first chamber may be in fluid communication with the first reservoir, and the second chamber may be in fluid communication with the second reservoir. The delivery tube may include a first conduit in fluid communication with the first chamber, a second conduit in fluid communication with the second chamber, and a third conduit configured to house an electrode therein. In this manner, a distal tip of the delivery tube is configured to be positionable adjacent to the one or more neural circuits for providing chemical and electrical stimulation thereto.

    Intravesical drug delivery device
    19.
    发明授权
    Intravesical drug delivery device 有权
    膀胱内药物输送装置

    公开(公告)号：US09561353B2

    公开(公告)日：2017-02-07

    申请号：US14455463

    申请日：2014-08-08

    Applicant: Massachusetts Institute of Technology ,  Children's Medical Center Corporation

    Inventor： Heejin Lee ,  Karen Daniel ,  Hong Linh Ho Duc ,  Michael J. Cima ,  Mario Castillo ,  Steven Froelich ,  Jordan Dimitrakov ,  Grace Y. Kim

    IPC: A61M31/00 ,  A61K9/00 ,  A61L29/16 ,  A61L29/06

    CPC classification number: A61M31/002 ,  A61K9/0034 ,  A61L29/06 ,  A61L29/16 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/45 ,  A61L2300/63 ,  A61M2202/06 ,  A61M2205/0216 ,  A61M2210/1085 ,  C08L83/04

    Abstract: Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.

    Abstract translation: 用于膀胱内给药和局部药物输送的植入装置。 该装置具有包括由生物相容性材料形成的中空管的主体; 管中含有药物的至少一个储存器; 以及可以释放药物的一个或多个孔。 该装置构造成用于微创地插入诸如膀胱的体腔中。 中空管可以是弹性的，以允许该装置从其初始形状弹性变形成细长形状以便通过导管，其中随后通过该装置可以返回或朝向其初始形状，以便于将装置保持在 体腔。 身体可以具有有效的狭窄的细长形状，以允许药物递送装置通过导管插入，而不必使身体变形，而包括有效地保持在体腔内的弹性突起。

    INTRAVESICAL DRUG DELIVERY DEVICE
    20.
    发明申请
    INTRAVESICAL DRUG DELIVERY DEVICE 有权
    内窥镜药物递送装置

    公开(公告)号：US20140350473A1

    公开(公告)日：2014-11-27

    申请号：US14455463

    申请日：2014-08-08

    Applicant: Massachusetts Institute of Technology ,  Children's Medical Center Corporation

    Inventor： Heejin Lee ,  Karen Daniel ,  Hong Linh Ho Duc ,  Michael J. Cima ,  Mario Castillo ,  Steven Froelich ,  Jordan Dimitrakov ,  Grace Y. Kim

    IPC: A61M31/00

    CPC classification number: A61M31/002 ,  A61K9/0034 ,  A61L29/06 ,  A61L29/16 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/45 ,  A61L2300/63 ,  A61M2202/06 ,  A61M2205/0216 ,  A61M2210/1085 ,  C08L83/04

    Abstract: Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.

    Abstract translation: 用于膀胱内给药和局部药物输送的植入装置。 该装置具有包括由生物相容性材料形成的中空管的主体; 管中含有药物的至少一个储存器; 以及可以释放药物的一个或多个孔。 该装置构造成用于微创地插入诸如膀胱的体腔中。 中空管可以是弹性的，以允许该装置从其初始形状弹性变形成细长形状以便通过导管，其中随后通过该装置可以返回或朝向其初始形状，以便于将装置保持在 体腔。 身体可以具有有效的狭窄的细长形状，以允许药物递送装置通过导管插入，而不必使身体变形，而包括有效地保持在体腔内的弹性突起。

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