公开(公告)号：US06437131B1

公开(公告)日：2002-08-20

申请号：US09678192

申请日：2000-10-04

Applicant: John F. Gerster ,  Kyle J. Lindstrom

Inventor： John F. Gerster ,  Kyle J. Lindstrom

IPC: C07D47104

CPC classification number: C07D401/04 ,  C07D401/14 ,  C07F9/6561

Abstract: A process for preparing 1H-imidazo[4,5-c]quinolin-4-amines is disclosed. The process involves reacting a 6H-imidazo[4,5-c]tetrazolo[1,5-a]quinoline with triphenylphosphine and hydrolyzing the product thereof

Abstract translation: 公开了制备1H-咪唑并[4,5-c]喹啉-4-胺的方法。 该方法包括使6H-咪唑并[4,5-c]四唑并[1,5-a]喹啉与三苯基膦反应并水解其产物

公开(公告)号：US5977366A

公开(公告)日：1999-11-02

申请号：US60010

申请日：1998-04-14

Applicant: John F. Gerster ,  Stephen L. Crooks ,  Kyle J. Lindstrom

Inventor： John F. Gerster ,  Stephen L. Crooks ,  Kyle J. Lindstrom

IPC: C07D215/42 ,  C07D471/04 ,  C07D215/38 ,  C07D413/04

CPC classification number: C07D471/04 ,  C07D215/42

Abstract: 1-substituted, 2-substituted 1H-imidazo[4,5-c]-quinolin-4-amines are disclosed. These compounds function as antiviral agents, they induce biosynthesis of interferon, and they inhibit tumor formation in animal models. This invention also provides intermediates for preparing such compounds, pharmaceutical compositions containing such compounds, and pharmacological methods of using such compounds.

Abstract translation: 1-取代的2-取代的1H-咪唑并[4,5-c] - 喹啉-4-胺。 这些化合物作为抗病毒剂起作用，它们诱导干扰素的生物合成，并且它们抑制动物模型中的肿瘤形成。 本发明还提供了制备此类化合物的中间体，含有这些化合物的药物组合物，以及使用这些化合物的药理学方法。

公开(公告)号：US5741908A

公开(公告)日：1998-04-21

申请号：US673712

申请日：1996-06-21

Applicant: John F. Gerster ,  Kyle J. Lindstrom

Inventor： John F. Gerster ,  Kyle J. Lindstrom

IPC: C07D471/04 ,  C07D401/04 ,  C07D401/14 ,  C07D471/14 ,  C07F9/6561 ,  C07D471/02 ,  C07D487/14 ,  C07F9/60

CPC classification number: C07D401/04 ,  C07D401/14 ,  C07F9/6561

Abstract: A process for preparing 1H-imidazo�4,5-c!quinolin-4-amines is disclosed. The process involves reacting a 6H-imidazo�4,5-c!tetrazolo�1,5-a!quinoline with triphenylphosphine and hydrolyzing the product thereof.

Abstract translation: 公开了制备1H-咪唑并[4,5-c]喹啉-4-胺的方法。 该方法包括使6H-咪唑并[4,5-c]四唑并[1,5-a]喹啉与三苯基膦反应并水解其产物。

公开(公告)号：US5389640A

公开(公告)日：1995-02-14

申请号：US938295

申请日：1992-08-28

Applicant: John F. Gerster ,  Stephen L. Crooks ,  Kyle J. Lindstrom

Inventor： John F. Gerster ,  Stephen L. Crooks ,  Kyle J. Lindstrom

IPC: C07D215/42 ,  C07D471/04 ,  C07D471/02 ,  A61K31/44

CPC classification number: C07D471/04 ,  C07D215/42

Abstract: 1-substituted, 2-substituted 1H-imidazo[4,5-c]-quinolin-4-amines are disclosed. These compounds function as antiviral agents, they induce biosynthesis of interferon, and they inhibit tumor formation in animal models. This invention also provides intermediates for preparing such compounds, pharmaceutical compositions containing such compounds, and pharmacological methods of using such compounds.

公开(公告)号：US07335773B2

公开(公告)日：2008-02-26

申请号：US11276074

申请日：2006-02-13

Applicant: John F. Gerster ,  Kyle J. Lindstrom ,  Stephen L. Crooks ,  Philip D. Heppner ,  Gregory J. Marszalek ,  Peter V. Maye ,  Bryon A. Merrill ,  John W. Mickelson ,  Michael J. Rice

Inventor： John F. Gerster ,  Kyle J. Lindstrom ,  Stephen L. Crooks ,  Philip D. Heppner ,  Gregory J. Marszalek ,  Peter V. Maye ,  Bryon A. Merrill ,  John W. Mickelson ,  Michael J. Rice

IPC: C07D471/02

CPC classification number: C07D471/04 ,  A61K31/4745 ,  A61K45/06 ,  C07D471/14 ,  A61K2300/00

Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.

Abstract translation: 咪唑并吡啶和四氢咪唑并吡啶化合物诱导细胞因子如干扰素和肿瘤坏死因子的生物合成。 该化合物显示抗病毒和抗肿瘤性质。 公开了制备可用于制备化合物的化合物和中间体的方法。

公开(公告)号：US06894165B2

公开(公告)日：2005-05-17

申请号：US10824232

申请日：2004-04-14

Applicant: John F. Gerster ,  Kyle J. Lindstrom ,  Stephen L. Crooks ,  Philip D. Heppner ,  Gregory J. Marszalek ,  Peter V. Maye ,  Bryon A. Merrill ,  John W. Mickelson ,  Michael J. Rice

Inventor： John F. Gerster ,  Kyle J. Lindstrom ,  Stephen L. Crooks ,  Philip D. Heppner ,  Gregory J. Marszalek ,  Peter V. Maye ,  Bryon A. Merrill ,  John W. Mickelson ,  Michael J. Rice

IPC: A61K31/4375 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4745 ,  A61K31/522 ,  A61P7/00 ,  A61P17/00 ,  A61P29/00 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D213/00 ,  C07D233/00 ,  C07D257/00 ,  C07D401/04 ,  C07D471/04 ,  C07D471/14 ,  C07D471/22 ,  C07D519/00 ,  C07D471/12 ,  C07D471/00

CPC classification number: C07D471/04 ,  A61K31/4745 ,  A61K45/06 ,  C07D471/14 ,  A61K2300/00

Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.

公开(公告)号：US06677334B2

公开(公告)日：2004-01-13

申请号：US10241931

申请日：2002-09-12

Applicant: John F. Gerster ,  Kyle J. Lindstrom ,  Gregory J. Marszalek ,  Bryon A. Merrill ,  John W. Mickelson ,  Michael J. Rice

Inventor： John F. Gerster ,  Kyle J. Lindstrom ,  Gregory J. Marszalek ,  Bryon A. Merrill ,  John W. Mickelson ,  Michael J. Rice

IPC: A61K315355

CPC classification number: C07D513/04 ,  C07D513/14 ,  C07D517/04

Abstract: Thiazolo-, oxazolo- and selenazolo[4,5-c]quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and/or tumor biosynthesis, necrosis factor, and inhibit the T-helper-type 2 immune response. The compounds are further useful in the treatment of viral and neoplastic diseases.

公开(公告)号：US06613902B2

公开(公告)日：2003-09-02

申请号：US10352606

申请日：2003-01-28

Applicant: John F. Gerster ,  Kyle J. Lindstrom

Inventor： John F. Gerster ,  Kyle J. Lindstrom

IPC: C07D4704

CPC classification number: C07D401/04 ,  C07D401/14 ,  C07F9/6561

Abstract: A process for preparing 1H-imidazo[4,5-c]quinolin-4-amines is disclosed. The process involves reacting a 6H-imidazo[4,5-c]tetrazolo[1,5-a]quinoline with triphenylphosphine and hydrolyzing the product thereof.

公开(公告)号：US06534654B2

公开(公告)日：2003-03-18

申请号：US10180678

申请日：2002-06-26

Applicant: John F. Gerster ,  Kyle J. Lindstrom

Inventor： John F. Gerster ,  Kyle J. Lindstrom

IPC: C07D4704

CPC classification number: C07D401/04 ,  C07D401/14 ,  C07F9/6561

Abstract: A process for preparing 1H-imidazo[4,5-c]quinolin-4-amines is disclosed. The process involves reacting a 6H-imidazo[4,5-c]tetrazolo[1,5-a]quinoline with triphenylphosphine and hydrolyzing the product thereof.

公开(公告)号：US5998619A

公开(公告)日：1999-12-07

申请号：US61401

申请日：1998-04-16

Applicant: John F. Gerster ,  Kyle J. Lindstrom

Inventor： John F. Gerster ,  Kyle J. Lindstrom

IPC: C07D471/04 ,  C07D401/04 ,  C07D401/14 ,  C07D471/14 ,  C07F9/6561 ,  C07D471/02 ,  C07D487/14

CPC classification number: C07D401/04 ,  C07D401/14 ,  C07F9/6561

Abstract: A process for preparing 1H-imidazo[4,5-c]quinolin-4-amines is disclosed. The process involves reacting a 6H-imidazo[4,5-c]tetrazolo[1,5-a]quinoline with triphenylphosphine and hydrolyzing the product thereof.