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公开(公告)号:US20140271648A1
公开(公告)日:2014-09-18
申请号:US14208861
申请日:2014-03-13
Applicant: Janssen Biotech, Inc.
Inventor: Ellen Chi , Judith Connor , Chichi Huang , Jarrat Jordan , Xiefan Lin-Schmidt , Jinquan Luo , Lu Lu , Christian Martinez , Galina Obmolova , Ronald Swanson
CPC classification number: C07K16/249 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92
Abstract: Broadly neutralizing interferon-α and interferon-ω antibody antagonists, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing are useful in the treatment of diseases associated with increased production of IFNα and IFNω.
Abstract translation: 广泛中和干扰素α和干扰素-ω抗体拮抗剂,编码抗体或片段的多核苷酸,以及制备和使用前述物质的方法可用于治疗与增加的IFNα和IFNω产生相关的疾病。