公开(公告)号：US20220281887A1

公开(公告)日：2022-09-08

申请号：US17680002

申请日：2022-02-24

申请人： Incyte Corporation

发明人： Stacey Shepard ,  Charles Cole ,  Nikoo Falahatpisheh ,  Kai Liu ,  Lixin Shao ,  Darius Vrubliauskas ,  Liangxing Wu ,  Wenqing Yao ,  Eddy W. Yue

IPC分类号： C07D491/22 ,  C07D471/22 ,  C07D471/20 ,  C07D471/18 ,  C07D519/00 ,  A61P35/00

摘要： The present application provides spirocyclic lactam compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

公开(公告)号：US11433071B2

公开(公告)日：2022-09-06

申请号：US16828315

申请日：2020-03-24

申请人： Incyte Corporation ,  Incyte Holdings Corporation

发明人： Yun-Long Li ,  Wenqing Yao ,  Andrew P. Combs ,  Eddy W. Yue ,  Song Mei ,  Joseph Glenn ,  Thomas P. Maduskuie, Jr. ,  Richard B. Sparks ,  Brent Douty ,  Chunhong He

IPC分类号： A61K31/519 ,  C07D471/04 ,  C07D487/04 ,  A61P29/00 ,  C07D519/00

摘要： The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

公开(公告)号：US11427597B2

公开(公告)日：2022-08-30

申请号：US17079094

申请日：2020-10-23

申请人： Incyte Corporation

发明人： Liangxing Wu ,  Neil Lajkiewicz ,  Wenqing Yao

IPC分类号： A61K31/4188 ,  C07D491/048 ,  C07D491/056 ,  A61K45/06

摘要： The present application provides heteroaryl amide compounds that activate the STING pathway to produce interferons, which are useful in the treatment of various diseases including infectious diseases and cancer.

公开(公告)号：US11406624B2

公开(公告)日：2022-08-09

申请号：US16518366

申请日：2019-07-22

申请人： Incyte Corporation

发明人： Alexander Sokolsky ,  Oleg Vechorkin ,  Kai Liu ,  Jun Pan ,  Wenqing Yao ,  Qinda Ye

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00

摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

公开(公告)号：US20220227752A1

公开(公告)日：2022-07-21

申请号：US17558824

申请日：2021-12-22

申请人： Incyte Corporation

发明人： Kai Liu ,  Jun Pan ,  Alexander Sokolsky ,  Oleg Vechorkin ,  Hai Fen Ye ,  Qinda Ye ,  Wenqing Yao

IPC分类号： C07D471/04 ,  C07D519/00

摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

公开(公告)号：US20220073509A1

公开(公告)日：2022-03-10

申请号：US17190151

申请日：2021-03-02

申请人： Incyte Corporation

发明人： Liangxing Wu ,  Neil Lajkiewicz ,  Yingda Ye ,  Zhenwu Li ,  Wenqing Yao

IPC分类号： C07D471/04

摘要： The present application provides tricyclic heterocyclic compounds that activate the STING pathway to produce interferons, which are useful in the treatment of various diseases including infectious diseases and cancer.

公开(公告)号：US20210388003A1

公开(公告)日：2021-12-16

申请号：US17344255

申请日：2021-06-10

申请人： Incyte Corporation

发明人： Jun Pan ,  Yu Bai ,  Liangxing Wu ,  Wenqing Yao

IPC分类号： C07D519/00 ,  A61K31/519

摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.

公开(公告)号：US20210347771A1

公开(公告)日：2021-11-11

申请号：US17119488

申请日：2020-12-11

申请人： Incyte Corporation

发明人： Liangxing Wu ,  Bo Shen ,  Jingwei Li ,  Zhenwu Li ,  Kai Liu ,  Fenglei Zhang ,  Wenqing Yao

IPC分类号： C07D471/04 ,  C07D487/04

摘要： Disclosed are compounds of Formula (I′), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

公开(公告)号：US20210205311A1

公开(公告)日：2021-07-08

申请号：US17138485

申请日：2020-12-30

申请人： Incyte Corporation

发明人： Hui Wang ,  Juan Carlos Almagro ,  Rebecca A. Buonpane ,  Peter Niels Carlsen ,  Taisheng Huang ,  Yong Li ,  Luping Lin ,  Horacio G. Nastri ,  Chao Qi ,  Shaun M. Stewart ,  Pramod Unnikrishnan Thekkat ,  Xiaozhao Wang ,  Liangxing Wu ,  Wenqing Yao ,  Jing Zhou ,  Wenyu Zhu

IPC分类号： A61K31/519 ,  A61K39/395 ,  A61P35/00 ,  A61K31/501 ,  A61K31/506 ,  A61K31/4985 ,  A61K31/444

摘要： The present application provides methods of treating cancer using a combination of an inhibitor of A2A and/or A2B and an inhibitor of PD-1 and/or PD-L1.

公开(公告)号：US11014923B2

公开(公告)日：2021-05-25

申请号：US16924905

申请日：2020-07-09

申请人： Incyte Corporation

发明人： Liang Lu ,  Liangxing Wu ,  Ding-Quan Qian ,  Wenqing Yao

IPC分类号： C07D471/04

摘要： The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR4 enzyme and are useful in the treatment of FGFR4-associated diseases such as cancer.