公开(公告)号：US20210179626A1

公开(公告)日：2021-06-17

申请号：US17174733

申请日：2021-02-12

Applicant: Genentech, Inc.

Inventor： Mark ZAK ,  F. Anthony ROMERO ,  Po-wai YUEN ,  Emily J. HANAN

IPC: C07D487/04 ,  C07D471/04 ,  C07D491/048 ,  C07D498/04 ,  C07D513/04

Abstract: Compounds of Formula I and methods of use as Janus kinase inhibitors are described herein.

公开(公告)号：US20190240227A1

公开(公告)日：2019-08-08

申请号：US16387187

申请日：2019-04-17

Applicant: Genentech, Inc.

Inventor： Mark ZAK ,  F. Anthony ROMERO ,  Yun-Xing CHENG

IPC: A61K31/519 ,  A61P11/06 ,  C07D487/04 ,  A61P29/00

CPC classification number: A61K31/519 ,  A61P11/06 ,  A61P29/00 ,  C07D487/04

Abstract: Compounds and salts thereof that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

公开(公告)号：US20180333416A1

公开(公告)日：2018-11-22

申请号：US15984747

申请日：2018-05-21

Applicant: Genentech, Inc.

Inventor： Mark ZAK ,  F. Anthony ROMERO ,  Yun-Xing CHENG

IPC: A61K31/519 ,  A61P11/06

CPC classification number: A61K31/519 ,  A61P11/06 ,  A61P29/00 ,  C07D487/04

Abstract: Compounds and salts thereof that are useful as JAK kinse inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.