公开(公告)号：US20200369956A1

公开(公告)日：2020-11-26

申请号：US16419206

申请日：2019-05-22

Applicant: General Electric Company

Inventor： Matthew David Butts ,  James Edward Murphy ,  Mark Daniel Doherty

IPC: C09K11/61 ,  C09K11/02 ,  H01L33/50 ,  F21V8/00

Abstract: Briefly, in one aspect, the present invention relates to processes for producing a stabilized Mn4+ doped phosphor in solid form and a composition containing such doped phosphor. Such process may include combining a) a solution comprising at least one substance selected from the group consisting of: K2HPO4, an aluminum phosphate, oxalic acid, phosphoric acid, a surfactant, a chelating agent, or a combination thereof, with b) a Mn4+ doped phosphor of formula I in solid form, where formula I may be: Ax [MFy]:Mn4+. The process can further include isolating the stabilized Mn4+ doped phosphor in solid form. In formula I, A may be Li, Na, K, Rb, Cs, or a combination thereof. In formula I, M may be Si, Ge, Sn, Ti, Zr, Al, Ga, In, Sc, Y, La, Nb, Ta, Bi, Gd, or a combination thereof. In formula I, x is the absolute value of the charge of the [MFy] ion and y is 5, 6 or 7.

公开(公告)号：US20160296641A1

公开(公告)日：2016-10-13

申请号：US15187115

申请日：2016-06-20

Applicant: General Electric Company

Inventor： Matthew David Butts ,  Robert Edgar Colborn ,  Peter John Bonitatibus, JR. ,  Andrew Soliz Torres

IPC: A61K49/10 ,  B82Y5/00 ,  A61K49/18

CPC classification number: A61K49/101 ,  A61K49/0002 ,  A61K49/04 ,  A61K49/0428 ,  A61K49/0485 ,  A61K49/1818 ,  A61K49/1848 ,  B82Y5/00 ,  B82Y30/00 ,  C01G35/00 ,  Y10S977/773 ,  Y10S977/779 ,  Y10S977/927 ,  Y10S977/928 ,  Y10T428/2982

Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprising a nanoparticulate transition metal oxide covalently functionalized with a silane-functionalized non-targeting zwitterionic moiety.

Abstract translation: 提供了用至少一个两性离子部分官能化的纳米颗粒的组合物，制备多个纳米颗粒的方法及其用作诊断剂的方法。 与其他纳米颗粒相比，纳米颗粒具有导致颗粒在体内的最小保留的特征。 纳米颗粒包含用硅烷官能化的非靶向两性离子部分共价官能化的纳米颗粒过渡金属氧化物。

公开(公告)号：US20140147387A1

公开(公告)日：2014-05-29

申请号：US13872539

申请日：2013-04-29

Applicant: General Electric Company

Inventor： Matthew David Butts ,  Robert Edgar Colborn ,  Peter John Bonitatibus, JR. ,  Andrew Soliz Torres ,  Brian Christopher Bales ,  Michael Ernest Marino ,  Bruce Allan Hay ,  Amit Mohan Kulkarni

IPC: A61K49/00

CPC classification number: A61K49/101 ,  A61K49/0002 ,  A61K49/04 ,  A61K49/0428 ,  A61K49/0485 ,  A61K49/1818 ,  A61K49/1848 ,  B82Y5/00 ,  B82Y30/00 ,  C01G35/00 ,  Y10S977/773 ,  Y10S977/779 ,  Y10S977/927 ,  Y10S977/928 ,  Y10T428/2982

Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprising a nanoparticulate transition metal oxide covalently functionalized with a silane-functionalized non-targeting zwitterionic moiety.

Abstract translation: 提供了用至少一个两性离子部分官能化的纳米颗粒的组合物，制备多个纳米颗粒的方法及其用作诊断剂的方法。 与其他纳米颗粒相比，纳米颗粒具有导致颗粒在体内的最小保留的特征。 纳米颗粒包含用硅烷官能化的非靶向两性离子部分共价官能化的纳米颗粒过渡金属氧化物。

公开(公告)号：US12195655B2

公开(公告)日：2025-01-14

申请号：US17966638

申请日：2022-10-14

Applicant: General Electric Company

Inventor： Samuel Joseph Camardello ,  Anant A. Setlur ,  James E. Murphy ,  Matthew David Butts

IPC: C09K11/77 ,  H01L33/50

Abstract: A phosphor composition includes an activated uranium-based phosphor having formula I or II. The phosphor is doped with Eu3+ [Ba1−a−bSraCab]x[Mg,Zn]y(UO2)z([P,V]O4)2(x+y+z)/3  (I) [Ba1−a−bSraCab]p(UO2)q[P,V]rO(2p+2q+5r)/2  (II) where 0≤a≤1, 0≤b≤1, 0.75≤x≤1.25, 0.75≤y≤1.25, 0.75≤z≤1.25, 2.5≤p≤3.5, 1.75≤q≤2.25, and 3.5≤r≤4.5 and formula II excludes the combination where a is 0, b is 0, p is 3.5, q is 1.75, and r is 3.5. Phosphor compositions further including formula VI or other luminescent materials, such as quantum dots, devices and displays are also provided.

公开(公告)号：US20230287265A1

公开(公告)日：2023-09-14

申请号：US17966638

申请日：2022-10-14

Applicant: General Electric Company

Inventor： Samuel Joseph Camardello ,  Anant A. Setlur ,  James E. Murphy ,  Matthew David Butts

IPC: C09K11/77 ,  H01L33/50

CPC classification number: C09K11/771 ,  H01L33/502

Abstract: A phosphor composition includes an activated uranium-based phosphor having formula I or II. The phosphor is doped with Eu3+


[Ba1-a-bSraCab]x[Mg,Zn]y(UO2)z([P,V]O4)2(x+y+z)/3  (I)



[Ba1-a-bSraCab]p(UO2)q[P,V]rO(2p+2q+5r)/2  (II)



where 0≤a≤1, 0≤b≤1, 0.75≤x≤1.25, 0.75≤y≤1.25, 0.75≤z≤1.25, 2.5≤p≤3.5, 1.75≤q≤2.25, and 3.5≤r≤4.5 and formula II excludes the combination where a is 0, b is 0, p is 3.5, q is 1.75, and r is 3.5. Phosphor compositions further including formula VI or other luminescent materials, such as quantum dots, devices and displays are also provided.

公开(公告)号：US20230159824A1

公开(公告)日：2023-05-25

申请号：US17919180

申请日：2021-04-13

Applicant: General Electric Company

Inventor： Samuel Joseph Camardello ,  Matthew David Butts ,  Anant A. Setlur

IPC: C09K11/77 ,  C09K11/61 ,  H01L33/50

CPC classification number: C09K11/771 ,  C09K11/7708 ,  C09K11/7738 ,  C09K11/7734 ,  C09K11/616 ,  H01L33/504

Abstract: Green-emitting phosphors are useful in devices including an LED light source radiationally coupled and/or optically coupled to the phosphors, which are selected from



[Ba1−a−bSraCab]x[Mg,Zn]y(UO2)z([P,V]O4)2(x+y+z)/3,
where 0≤a≤1, 0≤b≤1, 0.75≤x≤1.25, 0.75≤y≤1.25, 0.75≤z≤1.25; and
[Ba,Sr,Ca,Mg,Zn]p(UO2)q[P,V]rO(2p+2q+5r)/2,
where 2.5≤p≤3.5, 1.75≤q≤2.25, 3.5≤r≤4.5.

公开(公告)号：US09399075B2

公开(公告)日：2016-07-26

申请号：US13872539

申请日：2013-04-29

Applicant: General Electric Company

Inventor： Matthew David Butts ,  Robert Edgar Colborn ,  Peter John Bonitatibus, Jr. ,  Andrew Soliz Torres ,  Brian Christopher Bales ,  Michael Ernest Marino ,  Bruce Allan Hay ,  Amit Mohan Kulkarni

IPC: A61K49/04 ,  C01G35/00 ,  A61K49/00 ,  A61K49/18 ,  B82Y5/00 ,  B82Y30/00

CPC classification number: A61K49/101 ,  A61K49/0002 ,  A61K49/04 ,  A61K49/0428 ,  A61K49/0485 ,  A61K49/1818 ,  A61K49/1848 ,  B82Y5/00 ,  B82Y30/00 ,  C01G35/00 ,  Y10S977/773 ,  Y10S977/779 ,  Y10S977/927 ,  Y10S977/928 ,  Y10T428/2982

Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprising a nanoparticulate transition metal oxide covalently functionalized with a silane-functionalized non-targeting zwitterionic moiety.

Abstract translation: 提供了用至少一个两性离子部分官能化的纳米颗粒的组合物，制备多个纳米颗粒的方法及其用作诊断剂的方法。 与其他纳米颗粒相比，纳米颗粒具有导致颗粒在体内的最小保留的特征。 纳米颗粒包含用硅烷官能化的非靶向两性离子部分共价官能化的纳米颗粒过渡金属氧化物。

公开(公告)号：US20160144059A1

公开(公告)日：2016-05-26

申请号：US14550689

申请日：2014-11-21

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Matthew David Butts ,  Jason William Castle ,  Andrew Soliz Torres ,  Jeannette Christine Roberts ,  Binil Itty Ipe Kandapallil

IPC: A61K49/22

CPC classification number: A61K49/223 ,  A61K9/0009 ,  A61K9/5052

Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.

Abstract translation: 本公开内容涉及白蛋白微泡的组合物，其结合了相对于游离的天然HSA显示白蛋白微泡的结合偏好的一个或多个部分。 还讨论了白蛋白微泡组合物的生产和白蛋白微泡组合物在超声介导的递送治疗剂或诊断剂中的用途。