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公开(公告)号：US12042526B2
公开(公告)日：2024-07-23
申请号：US17936162
申请日：2022-09-28
Applicant: General Electric Company
Inventor： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Duh-Lan Lee , Allen Lawrence Garner
IPC: A61K38/18 , A61K35/19 , C12N13/00 , G01N33/487 , G01N33/49
CPC classification number: A61K38/1858 , A61K35/19 , C12N13/00 , G01N33/48707 , G01N33/49
Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
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公开(公告)号：US20230013598A1
公开(公告)日：2023-01-19
申请号：US17936162
申请日：2022-09-28
Applicant: General Electric Company
Inventor： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Duh-Lan Lee , Allen Lawrence Garner
IPC: A61K38/18 , A61K35/19 , G01N33/49 , C12N13/00 , G01N33/487
Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
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公开(公告)号：US11007285B2
公开(公告)日：2021-05-18
申请号：US16935998
申请日：2020-07-22
Applicant: General Electric Company
Inventor： Matthew David Butts , Jason William Castle , Andrew Soliz Torres , Jeannette Christine Roberts , Binil Itty Ipe Kandapallil
Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.
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公开(公告)号：US10383915B2
公开(公告)日：2019-08-20
申请号：US15251990
申请日：2016-08-30
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Dun-Lan Lee , Allen Lawrence Garner
Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
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公开(公告)号：US09078862B2
公开(公告)日：2015-07-14
申请号：US13912050
申请日：2013-06-06
Applicant: General Electric Company
Inventor： Vasile Bogdan Neculaes , Antonio Caiafa , Brian Duh-Lan Lee , Nicole Evelyn LaPlante , Andrew Soliz Torres , Allen Lawrence Garner
CPC classification number: A61K35/19 , A61K41/00 , A61N1/00 , C12N5/0644 , C12N13/00
Abstract: Embodiments of the disclosure relate to platelet activation and/or aggregation using electric pulses. In one embodiment, a platelet-containing sample is exposed to electric pulses. At least one of the electric pulses has a duration greater than 1 microsecond and a field strength below 50 kV/cm. In another embodiment, the electric pulses may be designed with particular field strengths and durations.
Abstract translation: 本公开的实施方案涉及使用电脉冲的血小板活化和/或聚集。 在一个实施方案中，将含血小板的样品暴露于电脉冲。 电脉冲中的至少一个具有大于1微秒的持续时间和低于50kV / cm的场强。 在另一个实施例中，电脉冲可以被设计为具有特定的场强和持续时间。
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Patent Agency Ranking
公开(公告)号：US10751429B2
公开(公告)日：2020-08-25
申请号：US16102368
申请日：2018-08-13
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Matthew David Butts , Jason William Castle , Andrew Soliz Torres , Jeannette Christine Roberts , Binil Itty Ipe Kandapallil
Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.
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公开(公告)号：US20200239868A1
公开(公告)日：2020-07-30
申请号：US16850727
申请日：2020-04-16
Applicant: General Electric Company
Inventor： Vasile Bogdan Neculaes , Andrew Soliz Torres , Steve Lambert Klopman
Abstract: The present disclosure relates to the generation of an activated platelet product in which one or more of the presence or absence of clots, the timing of clot formation (if present), and/or the mechanical strength of clots (if present) is controlled by the presence or concentration of calcium ions during the activation process. In certain embodiments, the calcium ion concentration is controlled in the presence of pulsed electric fields or a chemical activator (e.g., thrombin) as part of the activation process.
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公开(公告)号：US20190336578A1
公开(公告)日：2019-11-07
申请号：US16514662
申请日：2019-07-17
Applicant: General Electric Company
Inventor： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Dun-Lan Lee , Allen Lawrence Garner
IPC: A61K38/18 , C12N13/00 , A61K35/19 , G01N33/49 , G01N33/487
Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
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公开(公告)号：US20180237764A1
公开(公告)日：2018-08-23
申请号：US15955377
申请日：2018-04-17
Applicant: General Electric Company
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes , Allen Lawrence Garner , Andrew Soliz Torres
Abstract: In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
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公开(公告)号：US10052394B2
公开(公告)日：2018-08-21
申请号：US14550689
申请日：2014-11-21
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Matthew David Butts , Jason William Castle , Andrew Soliz Torres , Jeannette Christine Roberts , Binil Itty Ipe Kandapallil
CPC classification number: A61K49/223 , A61K9/0009 , A61K9/5052
Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.
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